1/8 Breathing seems automatic. But it's a finely tuned motor behavior that has to be controlled. In this preprint, I map the circuits that match a fly's respiration to the metabolic demands of flight and mitigate the risk of dehydration. 🧵🪰 www.biorxiv.org/content/10.6...
Thea Jacobs
@theajacobs.bsky.social
Postdoc in the Luschnig lab. Flyologist 🪰 here to share my excitement about actomyosin. Check out how contractility controls paracellular permeability here: https://shorturl.at/Wnb2n
Thrilled to share my first publication from my PhD is now out in Journal of Cell Biology!!!! 😇 💖 Have you ever wondered how multicellular vertices are maintained and remodeled in an epithelia? 💭 Here, we investigate the role of junctional kinase PAK4 in vertex maintenance and remodeling!
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
Two days left to apply for a PhD position in our group, see below!
🚨Job Alert: PhD in Theoretical Biophysics 🚨 we are looking for a PhD student to join our group at Uni Münster to work on models of multi-layered active materials @uni-muenster.de More details here: stellen.uni-muenster.de/jobposting/6... Please share and contact me if interested!
I love these funky basal epithelial cells in axolotl. Looks just like plant pavement cells
Great scientist, even better person 💕
Biologist Angelica Coculla is researching the internal circadian clock of fruit flies. A recent paper published in the journal Science shows that the insects can reset their internal clock through their behaviour. With the molecular rhythm, the sleep-wake cycle returned. #Biology
🌈 At a time when progress can't be taken for granted, I 'm especially proud to share this @natcellbio.nature.com Q&A piece. I had the pleasure to discuss with @gunawanlab.bsky.social about his inspiring journey as an LGBTQIA+ immigrant. #PrideInSTEM 👉 rdcu.be/fnXQ6 www.nature.com/articles/s41...
A scientist can come from anywhere - Nature Cell Biology
This June, we celebrate Pride by discussing with Felix Gunawan, assistant professor at the University of Toronto and co-affiliate group leader at the University of Münster, about his personal and acad...
nature.com
✨ Serving egg-cellent organization and fluorescent elegance 🥚 Partial Drosophila 🪰 ovariole with WGA staining of nuclear envelopes 🔬 📸 Image by Michelle Giedt #FluorescenceFriday 🐣
Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development! @karengrace12.bsky.social @nicolettapetridou.bsky.social 🔗 doi.org/10.1242/dev....
Tissue phase transitions in development: more than just mechanics
Summary: Tissue material phase transitions are classically thought to regulate tissue deformability. This Review emphasises their unexpected roles in directly influencing growth and patterning signall...
doi.org
Registration is now open! Secure your spot for the @sfb1348.bsky.social International Meeting “Mechanochemical signals at cellular interfaces” @uni-muenster.de from May 27–29, 2026! More informationen and registration: www.uni-muenster.de/SFB1348/en/m...
New work from our group now online @biorxiv-devbio.bsky.social 🤩
New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila See tinyurl.com/yhbwd9xh @sfb1348.bsky.social
Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026. Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w @uni-muenster.de
Looking forward to an exciting @sfb1348.bsky.social seminar with Lucia Baldauf @ucl.ac.uk on January 8, 2026. She will speak about "Illuminating Forces in Living Tissues". More info: www.uni-muenster.de/SFB1348/en/i... Everyone's welcome!
www.science.org/doi/10.1126/...
Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization
In vitro reconstitution shows how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly.
science.org
Interested in working in an exciting project on morphogenesis, in a great environment for imaging? 🪰🔬
🚨 PhD Position Available 🚨 I’m recruiting a PhD student to join my lab at the Multiscale Imaging Centre (MIC), Münster, Germany. www.bischofflab.com/jobs Fully funded ✅ #Cellbio #Morphogenesis #Microscopy #Drosophila #PhD (Details Below) Original Posting: stellen.uni-muenster.de/jobposting/d...
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰 We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila. I’ll soon hire my first #PhD student — feel free to reach out! #juniorPI #Science #devbio
Dynamic cellular interfaces reloaded!🎉 Happy and excited to receive extended funding @sfb1348.bsky.social @uni-muenster.de @mpi-muenster.bsky.social and to push our collaborative science forward in the next 4 years! Big thanks @dfg.de, reviewers, and everyone else involved for the continued support!
Dynamic cellular interfaces reloaded!🎉 Happy and excited to receive extended funding @sfb1348.bsky.social @uni-muenster.de @mpi-muenster.bsky.social and to push our collaborative science forward in the next 4 years! Big thanks @dfg.de, reviewers, and everyone else involved for the continued support!
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
Approximately 14,000 visitors attended the “Lange Nacht der Universitätsmedizin Münster”, which marked the highlight of the anniversary year celebrating 100 years of the Faculty of Medicine and the University Hospital. www.uni-muenster.de/Cells-in-Mot... @sfb1348.bsky.social @uni-muenster.de
Photo gallery: “Lange Nacht der Universitätsmedizin” – Impressions from the Multiscale Imaging Centre
On September 12, 2025, the University and University Hospital Münster opened their doors to the public during the “Lange Nacht der Universitätsmedizin”. At the Multiscale Imaging Centre, many visitors...
uni-muenster.de
Besuchen Sie uns zur „Langen Nacht der Unimedizin Münster“ am 12. September 2025! Zahlreiche Forschungsgruppen aus der Zell-Dynamik- und Imaging-Community der @uni-muenster.de und @sfb1348.bsky.social öffnen ihre Labore für die Öffentlichkeit! lange-nacht-muenster.de
Lange Nacht der Universitätsmedizin Münster - Lange Nacht - 100 Jahre Universitätsmedizin Münster
Über 12.000 Menschen aus 100 Ländern, 150 Berufe, mehr als 30 Ausbildungsgänge – willkommen in der lebendigen Welt der Universitätsmedizin. Willkommen zur Entdecken Sie die Universitätsmedizin Münster...
lange-nacht-muenster.de
Super cool work from our institute!
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology
Supracellular control and coordination of tissue morphogenesis, through supracellular actomyosin assemblies, that is what my lab @cellbiol-mrclmb.bsky.social @pdncambridge.bsky.social and I like to dig into at the moment! Fascinating and beautiful! journals.biologists.com/dev/article/...
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social
Using a simple model – #FruitFly eggs – biologist @theajacobs.bsky.social is investigating how cells build connections, and thus form tissues that only allow certain substances or cells to pass through. Here, she provides insight into her day-to-day research. @sfb1348.bsky.social uni.ms/d3ry0
How does the yolk get into the egg? Studies on the fruit fly | Thea Jacobs
Cells build connections in organisms, and thus, form tissues that only allow certain substances or cells to pass through. In her doctoral thesis, biologist Thea Jacobs has carried out investigations o...
uni.ms
Neurobiologist Bente Winkler @b-wink.bsky.social investigates how the brain reacts to #neuroinflammation. For this, she is using genetically modified #Drosophila flies that enable an artificial activation of the immune system. Read more: uni.ms/48q7k
Inflammation in the brain: My research on the fruit fly | Bente Winkler
Neurobiologist Dr Bente Winkler is investigating how fruit fly brains react to inflammation. To do this, she is using genetically modified fruit flies in which a reaction of the immune system can be a...
uni.ms
Exciting @sfb1348.bsky.social with Katja Rust (Philipps-University Marburg) on Thursday. She will speak about "A single-cell analysis of Hh and EGFR-RAS: Independent signaling pathways prevent tumorigenesis". More information: www.uni-muenster.de/SFB1348/en/i... Everyone is welcome!
It’s #FluorescenceFriday again! @maikbischoff.bsky.social encouraged me to post more beautiful images, so I hope you enjoy this image of Ajuba at Tricellular Junctions in #Drosophila 🪰 want to know more? Click here: doi.org/10.1016/j.cu...
🥰 Self-supervised, label-free 3D cell imaging is here Congrats to Cyril on this very cool first, first author publication 🏆! This started when he was a bachelor's student (and he's now completing his masters!). And many thanks to my other awesome co-authors🙏 elifesciences.org/articles/99848
Self-supervised, label-free 3D cell imaging is here
EPFL researchers introduce CellSeg3D, a self-supervised tool for 3D cell segmentation in fluorescence microscopy, eliminating the need for manual labeling and enhancing accessibility for various biolo...
actu.epfl.ch