Toth-Petroczy lab
@tothpetroczylab.bsky.social
Protein evolution, IDRs, bimolecular condensates, phenotypic mutations. Science and fun from the ATPlab.
Welcome to HZDR, Prof. Ágnes Tóth-Petróczy! Since June 2026, @tothpetroczylab.bsky.social has been a Research Team Leader at the Center for Advanced Systems Understanding (CASUS). Her research focuses on the function and evolution of intrinsically disordered proteins. www.hzdr.de/presse/tothp...
I am honored and excited about the opportunity to lead the Department of Systems Biology at the Center for Advanced Systems Understanding (CASUS) at HZDR @casusscience.bsky.social in Görlitz and join as a Professor at BIOTEC/CMCB @biotec-tud.bsky.social. www.casus.science/news-profess...
News — Professorship and tenured position: Saxony retains top computational biologist – CASUS – Center for Advanced Systems Understanding
Ágnes Tóth-Petróczy to become third full professor working at CASUS and BIOTEC
casus.science
I am honored and deeply grateful for the opportunity to continue being part of Dresden’s vibrant and collaborative scientific community as a joint Professor between @casusscience.bsky.social and @biotec-tud.bsky.social. My dream of doing science for life has come true.
TUD | Biotechnology Center (BIOTEC)@biotec-tud.bsky.social · 2mo agoWelcome Prof. Ágnes Tóth-Petróczy! New Professor of Systems Biology and Protein Evolution & joint group leader at BIOTEC @tudresden.bsky.social & CASUS. She focuses on disordered proteins - ones that lack a fixed 3D structure - yet play essential roles. Read more ➡️ tud.link/784yv9 #CMCBnews
We are very happy for our colleague Dr. Jonas Pöhls! After defending his Ph.D. in an interlaboratory project between Lab Shevchenko and @tothpetroczylab.bsky.social, Jonas will continue his scientific career as a postdoctoral fellow at the Vienna BioCenter. Stay in touch with @mpi-cbg.de friends!
This and much more is available in our preprint! Thanks to collaborating labs @tothpetroczylab.bsky.social, Alain Lescure, Irwin Jungreis @manoliskellis.bsky.social, and Diego Garrido, Federica Battistini @biologiaub.bsky.social @geneticsub.bsky.social @molevolub.bsky.social
Regulatory landscape of widespread stop codon readthrough in Drosophila
In stop codon readthrough (SCR), ribosomes continue to translate past the stop. While programmed SCR is rare in mammals, it appears remarkably widespread in insects, yet its regulation and biological ...
biorxiv.org
Have you heard of our biomolecular condensate database before? Meet the CD-CODE team at the EMBO Phase Separation Symposium 👇
CrowDsourcing COndensate Database & Encyclopedia@cdcode.bsky.social · 4mo agoAre you at the #EMBO @embl.org #EESPhaseSeparation symposium? Let's meet at poster # 105 (Follow Helix A!) today 🙌 Thanks to the organizers for this opportunity to interact with the #condensate #research community! @events.embl.org @mpi-cbg.de @tothpetroczylab.bsky.social cd-code.org
CD-CODE v2.2 RELEASE is live🤩 Our #database grew: 💡10 new #condensates 💡639 new #condensate - #protein connections 💡107 new c-mods 💡10 new #condensatopathies 🟣Find your favorite condensate cd-code.org and 👀see more details about the #release: cd-code.org/release #cdcode #IDP #RBP #DatabaseUpdate
Based on this, we introduce Pinc (“probability of interface native contacts”): a simple and interpretable protein-protein interaction score for #alphafold (AF2/AF3) models. Colab + CLI: git.mpi-cbg.de/tothpetroczy... Feedback is appreciated. #rstats
Pinc: a simple probabilistic AlphaFold interaction score. 👇Congratulations to @mbadonyi.bsky.social! 🎉💕
Mihaly Badonyi@mbadonyi.bsky.social · 6mo agoMy first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers. www.biorxiv.org/content/10.6...
I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
Max Planck Institute of Molecular Cell Biology and Genetics@mpi-cbg.de · 9mo agoWatch this video about the work of the research group of @agnestoth.bsky.social @mpi-cbg.de & @csbdresden.bsky.social. Agnes and her group work on protein plasticity and evolution. For her work, Agnes recently received the Schering Young Investigator Award 2025! youtu.be/lEpvGu3J63M?...
The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...
💡With a #relational structure, programmatic access #API and improved search capabilities, CD-CODE 2.0 easily integrates into #datascience and digital #biology workflows, broadening its versatility and creating connections between condensate biology and #therapeutic development. 🔗 cd-code.org
CD-CODE is a great example of an interdisciplinary teamwork between computational and experimental biologists and software engineers! #Thankyou to all the authors of @tothpetroczylab.bsky.social, the biomolecular condensate community of @mpi-cbg.de, @hymanlab.bsky.social, and Dewpoint Therapeutics!
Our enhanced knowledge base for condensates is online @narjournal.bsky.social! Congratulations to the first authors @kkuznetsova.bsky.social and @mscheremetjew.bsky.social and all co-authors & curators! What a wonderful team effort to advance condensate research! 🤩 @mpi-cbg.de @hymanlab.bsky.social
CrowDsourcing COndensate Database & Encyclopedia@cdcode.bsky.social · 10mo agoCD-CODE 2.0 is now published in @narjournal.bsky.social 🤩 CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies 👀 doi.org/10.1093/nar/...
Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...
New Perspectives on the Hidden World of Proteins
Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy
mpi-cbg.de
AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology
🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 ssp2025.squarespace.com ▶️ @ssp2025.bsky.social
Novel Research in Biological Artificial Intelligence: Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence @mpi-cbg.de and @csbdresden.bsky.social. More information: www.mpi-cbg.de/news-outreac...
Novel Research in Biological Artificial Intelligence
Expressions of interest and nominations for a Max Planck Director to lead research in the field of Biological Artificial Intelligence.
mpi-cbg.de
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen https://go.nature.com/40wXMx6
How we’re rebuilding the Weizmann Institute — and our hopes for a better future
Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity.
go.nature.com
Big news 🎉 We are excited to announce the new TUD graduate school "Biomolecular Condensates: From Physics to Biological Functions", with 12 members from PoL! Through this school, we will train a new generation of scientists working on #condensates at the interphase between theory and experiments 🤓⤵️
TU Dresden@tudresden.bsky.social · last yr.Hochaktuelles Themenfeld an der Schnittstelle von Physik, Biologie und Polymerforschung: Die @dfg.de fördert ab 2026 mit rund 7 Millionen Euro ein neues Graduiertenkolleg zur Erforschung biomolekularer Kondensate in #Dresden. 🔬 ℹ️ tu-dresden.de/tu-dresden/n...
The latest release was supported by the #condesathon joined by @mpi-cbg.de condensate community🤩 Big #thankyou to all the participants from @hymanlab.bsky.social, @tothpetroczylab.bsky.social and von Appen labs for your support and enthusiasm!💜
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...
SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions
Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions
doi.org
One week left to apply to the Physics of Life MSc this year! Students learn first-class research skills and can also avail of #scholarships to aid their studies. Learn more and apply: physics-of-life.tu-dresden.de/career-educa... #internationalstudents #MSc #EnglishMSc #Physics #studyabroad
TUD | Center for Molecular and Cellular Bioengineering (CMCB)@cmcb-tud.bsky.social · last yr.Good news: there will be 3 scholarships available for Physics of Life MSc students starting in 2025! ✅ €300/month for 1 year ✅ No separate application—admitted students are automatically considered. Apply now ➡️ tud.link/vejrmx #Biophysics #PhysicsofLife #StudyinGermany #Masters #Biology
Exciting that CD-CODE is now connected to THE go-to resource for everything protein-related! It's a great step forward, directing further developments and outlook for our project @tothpetroczylab.bsky.social @mscheremetjew.bsky.social 🥳
CrowDsourcing COndensate Database & Encyclopedia@cdcode.bsky.social · last yr.We're really excited that CD-CODE is now cross-referenced by #UniProt and has already been included in the latest release: www.uniprot.org/release-note... Spreading knowledge about #biomolecular #condensates 🥳 @ebi.embl.org @sib.swiss @mpi-cbg.de @tothpetroczylab.bsky.social @hymanlab.bsky.social
Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swlenz.bsky.social and WillisChow @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social bmcgenomics.biomedcentral.com/articles/10....
Deep learning tools predict variants in disordered regions with lower sensitivity - BMC Genomics
Background The recent AI breakthrough of AlphaFold2 has revolutionized 3D protein structural modeling, proving crucial for protein design and variant effects prediction. However, intrinsically disorde...
bmcgenomics.biomedcentral.com
New Publication of the @tothpetroczylab.bsky.social: The group found that prediction tools are less sensitive in intrinsically disordered regions of proteins (IDRs). Since they are common & important, new methods tailored to these regions are needed. bmcgenomics.biomedcentral.com/articles/10....
The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...
You can download my protein structure-inspired artwork from pdb webpage: pdb101.rcsb.org/sci-art/bezs... @rcsbpdb.bsky.social @pdbeurope.bsky.social #sciart
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
