Tessera
Folgen

@voigtvision.bsky.social

🔬 & 👁️ & 🐟-News & Views by Fabian Voigt - Branco Weiss Fellow in the Engert lab at MCB @harvard.edu. Previously at UZH Zurich with Fritjof Helmchen. #mesoSPIM developer

54 Posts614 Follower1041 Folgt
@voigtvision.bsky.social · 3mo ago

🚨 New Preprint alert 🚨: The #Altair #lightsheet #Microscopy family is growing: Altair-dvOPM - an open-access direct-view oblique plane microscope based on photographic lenses by @kevin-dean.bsky.social & @retof.bsky.social Manuscript: www.biorxiv.org/content/10.6... & thedeanlab.github.io/altair/

Kevin Dean@kevin-dean.bsky.social · 3mo ago

Altair Direct View OPM Preprint! We built a simplified direct-view oblique-plane microscope for imaging big, optically accessible specimens with a single-objective light-sheet geometry. Delivers... • ~5.4 mm field of view • ~2.6 μm, ~3.4 μm, and ~17.8 μm resolution in X/Y/Z

@voigtvision.bsky.social · 4mo ago

🚨New Lab Alert!🚨 Superhappy to announce that I will start my lab combining photonics & neuroscience at the Max Planck Center for Physics & Medicine in Erlangen & @mpi-scienceoflight.bsky.social in January 2027! Reach out if you're interested in internships, BSc, MSc & PhD & postdoc projects!

Max Planck Center for Physics and Medicine buildingMax Planck Instittute for the Science of Light building
@voigtvision.bsky.social · 4mo ago

Delightful new preprint by @tuthill.bsky.social @bingbrunton.bsky.social & Co: www.biorxiv.org/content/10.6... "This exercise teaches us nothing about either animal and exposes a core peril of connectome-body models: behavioral fidelity is achievable without biological fidelity" 😂😂😂

The digital sphinx: Can a worm brain control a fly body?

Animal intelligence is not purely a product of abstract computation in the brain, but emerges from dynamic interactions between the nervous system and the body. New connectome datasets and musculoskeletal models now enable integrated, closed-loop simulations of the neural and biomechanical systems of the fruit fly Drosophila, an ideal model organism to investigate embodied intelligence. However, many biological parameters of the nervous system and the body, as well as how they interface, remain unknown. To fill such gaps, researchers are turning to deep reinforcement learning (DRL), a data-driven optimization framework, to create virtual animals that imitate the behavior of real animals. Here, we provide a cautionary tale about the interpretation of such models. We constructed a virtual chimera of two phylogenetically distant species: a connectome of the C. elegans nematode worm and a biomechanical model of the fly body. The worm connectome receives sensory information from the fly body, and an artificial neural network is trained with DRL to map worm motor neuron activations to the fly's leg actuators. The resulting digital sphinx produces highly realistic fly walking - yet it is biologically meaningless. This exercise teaches us nothing about either animal and exposes a core peril of connectome-body models: behavioral fidelity is achievable without biological fidelity, making such models easy to overinterpret. Done carefully, virtual animals can be powerful partners to biological experiments, but only if their components and interfaces are grounded in biology. ### Competing Interest Statement The authors have declared no competing interest. NIH, U01NS136507, R01NS14543

biorxiv.org

John Tuthill@tuthill.bsky.social · 4mo ago

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

@voigtvision.bsky.social · 12mo ago

Thanks to @nvladimus.bsky.social the @mesospim.bsky.social #lightsheet #Microscope community is now on forum.image.sc/tag/mesospim !

mesoSPIM: Clear Images. Big samples. Open source.@mesospim.bsky.social · 12mo ago

📣We have opened our official User Forum: forum.image.sc/tag/mesospim In this forum you can connect with 🔬developers and the image analysis experts. Ask your burning questions about the #mesoSPIM hardware, software, and image processing, or help the beginners to get started! Tip: use project tags!

@voigtvision.bsky.social · 12mo ago

Definitely the most unexpected @mesospim.bsky.social #lightsheet #microscopy application of the past years: Hunting dark matter with a lightsheet microscope! #astronomy 🔭🔬https://arxiv.org/abs/2503.20732

mesoSPIM: Clear Images. Big samples. Open source.@mesospim.bsky.social · 12mo ago

💥How can light-sheet help reveal dark matter?💥 Join Prof. Laura Baudis @lbaudis.bsky.social at #mesoSPIM Symposium, Oct 13–15 in Zurich or online, to see how light-sheet fluorescence microscopy 🔬 is used to image nuclear ☢️ recoil tracks to detect elusive particles! Register now: t.uzh.ch/1Ss

mage presenting one of the speakers for the 10 Years of mesoSPIM symposium. Background of the image is a microscopy picture showing blood vessels in magenta and glial cells in cyan on a black field. On the left, the photo of the speaker is contained in a white-rimmed circle, on the right text reads: "Laura Baudis, University of Zurich, Switzerland" followed by the talk title "Probing dark matter and neutrinos with light sheet microscopy". On the bottom right reads "10 Years of mesoSPIM Symposium”
@voigtvision.bsky.social · last yr.

Thanks to expansion microscopy, clever labeling, and modern segmentation approaches, doing connectomics with #light #microscopy has become feasible - huge congratulations Mojtaba & the Danzl lab at @istaresearch.bsky.social ! www.nature.com/articles/s41...

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

nature.com