We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below: www.nature.com/naturecareer...

Postdoctoral Scientist | PNAC | Dr Ana Tufegdzic Vidakovic | LMB 2142 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12857096

Postdoctoral Scientist Salary £42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...

nature.com

And that’s a wrap! 🎉 Our first conference of 2026 is complete, and what a fantastic way to start the year! We hope to see both familiar and new faces at the next #DRRSC meeting in 2028. Click here to Sign up for updates on the conference series: bit.ly/4bceiZb

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages

Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

science.org

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...

Cohesin drives chromatin scanning during the RAD51-mediated homology search

Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

science.org

I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...

A role for human senataxin in contending with pausing and backtracking during transcript elongation

Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…

sciencedirect.com

‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)

New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊 www.tandfonline.com/doi/full/10....

From serendipity to strategy: molecular glue degraders in cancer therapeutics

Targeted protein degradation is an elegant therapeutic strategy that harnesses the cell’s own degradation machinery to selectively eliminate target proteins. This approach marks a paradigm shift in...

tandfonline.com

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!

Update on #Recombination25 Conference! 🚨 📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT! 🌟Grants are available for students, postdocs & junior investigators!🌟 For more details, visit bit.ly/41v8IuK or email Felicity at 📧felicity@fusion-conferences.com @westlabcrick.bsky.social

Talk submission deadline coming up on 10th February 2025!

Fusion Conferences@fusionconf.bsky.social · 2y ago

🚨 DEADLINE UPDATE 🚨 The #Recombination25 talk submission deadline has been EXTENDED! 📅 🔔 NEW DEADLINE: 10th February 2025. This is the FINAL extension, so don’t miss out on the chance to share your research! Submit your abstract today! 🌟 bit.ly/3VunqAk

The West lab @crick.ac.uk has finally joined bluesky! Looking forward to sharing (and discovering!) new work 🧬 #recombination #dnarepair #BRCA #cryoEM #cellbiology