Thrilled to share our latest work from the lab, published today in Science Advances @science.org Our findings reveal a previously unrecognized PRDX1-dependent mechanism that safeguards RNA polymerase I-dependent transcription, and ribosomal RNA biogenesis. www.science.org/doi/10.1126/...

Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage

Peroxiredoxin 1 (PRDX1) is a highly conserved, thiol-dependent peroxidase that rapidly scavenges reactive oxygen species to modulate redox signaling. PRDX1-null mice exhibited genomic instability, sho...

science.org

🚨 Preprint Alert! 🚨 Ever wondered how the nucleolar genome is protected from oxidative damage? Check our new preprint uncovering a previously unrecognized role of Peroxiredoxin 1 (PRDX1) in safeguarding ribosomal DNA (rDNA) from oxidative damage. www.biorxiv.org/content/10.1...

Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage

Peroxiredoxin 1 (PRDX1) is a highly conserved, thiol-dependent peroxidase that rapidly scavenges reactive oxygen species to modulate redox signaling. PRDX1-null mice exhibited genomic instability, sho...

biorxiv.org

🧪 A new method called MagIC-Cryo-EM allows scientists to use powerful #CryoEM techniques to examine proteins that have been difficult to study so far.

The (molecular) shape of you

New methods allow scientists to use a powerful technique known as cryo-EM to examine proteins that have been difficult to study so far.

buff.ly

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩 events.faseb.org/event/11797f...

Celebrating my brother’s graduation at The George Washington University for his Master of Engineering in Cloud Computing! Brother Jacques, you made us proud! Your hard work paid off! 🎉👏🏽👏🏽👏🏽

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. shorturl.at/QA6T1

The spring is back for real in Maryland!

The Jiang lab@Moffitt is attending @ASBMB! If you are interested in redox biology and cancer metabolism, check out our posters as listed below on Monday, April 14th, 2025! See you in Chicago! We are hiring now!

Check out our new review paper in @cp-cellreports.bsky.social We summarized recent advances in understanding the complex interplay between DNA damage response and metabolism, focusing on how this crosstalk affects cancer therapy resistance. www.cell.com/cell-reports...

Abstracts are due TOMORROW! Please share!

Isaac Harris@harrislab.bsky.social · 2y ago

📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨 Registration free! Speakers chosen from abstracts and non-faculty only! Amazing poster session and workshops! Sign up today at: www.cancermetabolismshowcase.org

I thank the NCI Center for Cancer Research for shedding light on our most recent publication. ccr.cancer.gov/news/article...

Targeting two proteins leaves some cancer cells vulnerable to chemotherapy | Center for Cancer Research

Targeting two proteins that cancer cells rely on to sustain their metabolism and DNA repair capabilities can double the survival rate of mice with lung cancer tumors. Cross referencing with data from ...

ccr.cancer.gov

To all the charlatans bragging about curing cancer in 5 years with AI: you have no idea what you’re taking about.

I was hoping that my first bsky post would be more cheerful. I recently joined NIH (NIEHS) as a PO. I fought hard for this position and was so excited to support health science from a new vantage point… I picked up my life and moved to NC. Unfortunately, my time at NIEHS was short lived.

TIRING!

Mark Cuban@mcuban.bsky.social · 2y ago

Our next president will have to be technologically competent, at least , in order for us to sustain our place in the world. This will become increasingly obvious over the next 4 years as AI gets more powerful This isn’t necessarily bad. Truly. Done right, we will be a better, more equal society

Happy Black History Month!

Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic. globalnews.ca/news/9793403...

Check out our new paper just out in Redox Biology! Leveraging metabolism-focused CRISPR screen, we established a gene dependency map between DNA damage response and metabolism. We identified peroxiredoxin 1 as a key driver of resistance to ATM inhibition. www.sciencedirect.com/science/arti...

Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition

Metabolic pathways fuel tumor progression and resistance to stress conditions including chemotherapeutic drugs, such as DNA damage response (DDR) inhi…

sciencedirect.com

Excited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15

About 10 minutes after your first chalk talk with comments like: I don’t see how your work is going to reshape the field. Of course, I don’t know either. 😂😂

Fake news! Please read the entire study. It is fluoride over-exposure, and it is a 1.6 drop in IQ. I don’t want to lose my teeth to adjust to a standard deviation.

Eric Topol@erictopol.bsky.social · 2y ago

Is fluoride exposure associated with lower IQ scores in children? jamanetwork.com/journals/jam... A new systematic review of 74 studies says yes.

Drinking alcohol raises the risk of developing seven types of cancer, according to a new advisory from U.S. Surgeon General Vivek Murthy.

The U.S. Surgeon General wants cancer warnings on alcohol. Here's why

Drinking alcohol raises the risk of developing seven types of cancer, according to a new advisory from U.S. Surgeon General Vivek Murthy.

npr.org

First post here, how exciting!! 🥳 📣💻[JOB OFFER] I am looking for a postdoc with experience in QM/MM, MD and biosystems, and who would be motivated to study the formation mechanisms of oxydative histone modifications. Please share! #compchem #histones #PTM #redox www.linkedin.com/posts/activi...

Emmanuelle Bignon on LinkedIn: Job offer - pdoc CHROM

📢🧬I have a postdoc position open for people with experience using QM/MM on biosystems! Do not hesitate to apply if you're interested in investigating the…

linkedin.com

No offense, but people talk about A.I. and machine learning in 2024 like folks used to talk about microarray in the late 1990’s. They have no idea what they are talking about, but they say it anyway because it sounds smart.

No need for hallucinations, there are still plenty of important open questions in science

Itai Yanai@itaiyanai.bsky.social · 2y ago

A.I. hallucinations are reinvigorating the creative side of science. They speed the process by which scientists and inventors dream up new ideas and test them to see if reality concurs. It’s the scientific method only supercharged helping scientists open new frontiers www.nytimes.com/2024/12/23/s...

Do you want to work as a #postdoc in our group in a Hospital Research Institute in Madrid?🏥🔬 Interested in how #mitochondria and #redox signalling/stress can influence #stroke outcome and #inflammation?🧠💊 Apply up to 26 December at n9.cl/iunkw (ref 72/2024) Full call n9.cl/gijjd Please repost 😉

Excited to announce the next round of the @utaustin.bsky.social Trailblazer Postdoc Symposium. I'd love to see some #devbiol folks join us! Nominate postdocs! Nominate yourself! I Questions? DM me! Please amplify! @socdevbio.bsky.social app.smartsheet.com/b/form/9b7f2...

Don’t like a book? Don’t read it. Pretty simple.

Three minutes following the rejection of your manuscript revised 3 times in Nature. 😁

A nice piece. elifesciences.org/articles/102...

Point of View: Applied research won’t flourish without basic science

Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.

elifesciences.org

ACSL4 promotes metastatic extravasation by enhancing membrane fluidity and invasion "Our work establishes the dual functions of PUFA-lipids in tumor progression and metastasis that may be exploitable for therapeutic development." www.cell.com/cell/abstrac...

ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization

In vivo metastasis modeling and CRISPR screening identify mediators of ovarian cancer metastasis to distant organs, highlighting the dual functions of unsaturated lipids in promoting extravasation and colonization.

cell.com