Kidney disease affects 1 in 10 of the UK population and has largely been overlooked in the UK 10 Year Health Plan. Please sign this petition by Thursday 9th October to emphasise the importance of a national strategy for kidney disease. www.ukkidney.org/prime-minist...

Great talk about the Hidden initiative from Kate Bramham and detecting CKD in the community in London. Absolutely inspirational @kidneyresearchuk.org

Having a fantastic time listening to all the progress in kidney research in the UK @kidneyresearchuk.org driving discoveries. Fantastic talk @willkidney.bsky.social about how large well designed trials have changed our practice in nephrology

Your kidneys are working hard for you every day, every hour. Return the favor with these small habits that lead to lifelong health. 💬 Which of these do you already do? Which one could you start this week? #KidneyFacts #HealthyKidneys #NephrologyTips #BIGKiDsStudy #KidneyHealthAwareness #sampsonlab

Sibeprenlimab inches closer to approval www.hcplive.com/view/fda-acc... feat @brendonneuen.bsky.social Phase 3 RCT next week at #ERA25 (& some journal?)

FDA Accepts, Grants Priority Review to Sibeprenlimab BLA for IgA Nephropathy

With the priority review acceptance of the Biologics License Application, the FDA has assigned a PDUFA target action date of November 28, 2025.

hcplive.com

Sparsentan for FSGS?? It's alive.... ir.travere.com/press-releas...

It’s #WorldImmunizationWeek Vaccines have saved 154 million lives in the last 50 years. That’s 6 lives every minute. A reminder of what is #HumanlyPossible. Science saves lives. #VaccinesWork bit.ly/wiw2025

So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...

Reprogramming site-specific retrotransposon activity to new DNA sites - Nature

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...

nature.com

Interesting!

Cathy Quinlan ☘️ 🇦🇺 🌱@cathyquinlan.bsky.social · last yr.

1️⃣ Now this is amazing! 🎉 My PhD student Gráinne Butler led a groundbreaking study using Epic EMR data to detect genetic kidney disease before symptoms appeared!

Other than the brain, our immune system is the most complex part of the human body. For the first time, sequencing receptors of B and T cells, along w/ generative A.I., enabled diagnosis of medical conditions such as lupus. That's just for starters. erictopol.substack.com/p/the-first-...

What an exciting time to be a nephrologist. Yet another really promising therapy for IgA. Decreases proteinuria significantly, likely will be spoilt for choice soon but how will be choose the right meds for the right patient?

NEJM.org@nejm.org · last yr.

Among patients with IgA nephropathy, treatment with iptacopan, which inhibits the alternative complement pathway, resulted in a significant reduction in proteinuria as compared with placebo. Full APPLAUSE-IgAN trial results and Research Summary: nej.md/3UmrOkh #MedSky #Nephrology

Not apologising for posting this paper twice as really excited about ProtGPS. Logical next step in protein modelling after the success of alphafold2. Not only will help predict pathogenicity of genetic variants but can incorporate elements for subcellular compartmentalisation in gene therapy design

Whitehead Institute@whiteheadinstitute.bsky.social · last yr.

Researchers in the Young Lab at Whitehead Institute and the Barzilay Lab in MIT's CSAIL have developed ProtGPS, a machine learning model that predicts which cellular compartments a protein will reside in. This tool could inform the development of more effective therapies. shorturl.at/5KdVE

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Protein codes promote selective subcellular compartmentalization

Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

science.org

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila Monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

No idea how the academic world would cope without pubmed

Trish Greenhalgh@trishgreenhalgh.bsky.social · 2y ago

If they pull PubMed, do we have a plan B? #academicsky?

Fascinating read: history of ISKDC. Our current management of nephrotic syndrome not very different from this first nephrotic syndrome RCT. (Other than AZA which was shown not to be useful in iNS) media.springernature.com/full/springe...

Why we need to start monitoring #BP before adulthood for #cardiovascular #prevention #CvPrev Adolescent #BloodPressure & Early Age #Stroke in @nejm.org Evidence evidence.nejm.org/doi/full/10....

Adolescent Blood Pressure and Early Age Stroke

Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardi...

evidence.nejm.org

This 13-year-old received 3 antivirals and plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza— not even during H1N1. #H5N1 is alarming; we must boost surveillance, testing, prevention, and education to control it. www.nejm.org/doi/full/10....

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection | NEJM

Influenza A(H5N1) viruses are an emerging zoonotic threat and have spread widely throughout birds in North America. Recently, influenza A(H5N1) infection led to serious illness in a teenager in Canada.

nejm.org

Chronic Kidney Disease is rising in prevalence--I have signed this petition for the World Health Organisation to recognise kidney health as a priority, do consider signing to prioritise preventing premature death from kidney disease #nephsky #medsky #pedsky

Fernanda Arce-Amaré@ferarceamare.bsky.social · 2y ago

Guatemala is leading a historic effort at the @who.int to recognize kidney disease as a global health priority. This will drive global strategies to improve care and reduce the burden of kidney disease. Sign the petition: ow.ly/a7J350Tfpjp #KidneyHealthMatters #UHCDay TY @momenabbasi.bsky.social

😱 Have never dared to use any of these but surely you would check through carefully if you did! Worrying that these passed peer review, editorial boards etc 🤔

Altmetric@altmetric.com · 2y ago

THREAD This Is The Story Of The The Pernicious Rise of AI-Generated Papers and their Online Impact An Incomplete History Told In The Voice of Documentarian Adam Curtis 1/31

#PedSky appreciation post: Dr. Weyand’s posts are why I now check ferritin/CRP for every anemia screen (w CBC + retic)! I’ve caught so many w single digit ferritin levels even if Hgb is “normal” 😱 It’s also an issue in “picky eaters” even if they’re not menstruating

Shematologist, MD@shematologist.medsky.social · 2y ago

Just your regular reminder that iron deficiency affects ~40% of 12-21 yo females and still no one cares. jamanetwork.com/journals/jam...

A great keynote by Moin Saleem from Bristol UK, followed by a terrific discussion @rfsgsinitiative.bsky.social @genetickidneydoc.bsky.social @opeyemiolabisi.bsky.social @gbadegesinlab.bsky.social

Some papers are very difficult to read but that doesn’t necessarily mean they're deeper than other papers. Authors must work very hard to make their story easy to read and understand by others. Or as Stephen King says: "the shorter the book, the less bullshit".

Hello and thank you to all who have followed us so far! Look out for some of our posts coming to #Bluesky soon 😍 In the meantime, if you are living with #ChronicKidneyDisease and need support from us, please visit our website: kidneycareuk.org/get-support/ #KidneyCareUK #CKD #CKDSupport #Dialysis

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

1/9 🤔 Why doesn't an elevated BUN lead to extreme thirst? If increased serum osmolarity compels us to seek water, uremia should be a significant driver of this craving. And yet, it isn't. Let's examine why.

❤️Great visual abstract of the original ISKDC study for NS from 50 years ago! high dose steroids magically melts away childhood NS but can we do better? In an ideal world: ✔️equally efficacious induction therapy ✔️minimal side effects ✔️cost effective-equal access in LMICs where NS incidence higher

Michelle Rheault, MD@rheaultm.bsky.social · 2y ago

Know your Ped Neph History! In the 1970s, the International Study of Kidney Disease in Children completed a trial where every child (3mo - <16 years) who presented with nephrotic syndrome was biopsied. We still quote these numbers to families today. Visual Abstract 👉 shop.lww.com/Handbook-of-...

😱 although hopefully a risk factor only in select age groups.

Jasmine Sethi@jasminenephro.bsky.social · 2y ago

💇‍♀️Brazilian hair straightening and Oxalate Nephropathy 😱 www.kidney-international.org/article/S008...

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d6: you guessed it - postrenal AKI

To celebrate the growing #medsky / #nephsky community, I will post one silly med/kidney cartoon every day for one month! d5: intrarenal AKI