RNA-binding proteins (RBPs) often bind numerous transcripts - but do they act through a network effect? Our new paper in @plosbiology.org shows that the highly conserved LIN28 RBP controls developmental timing in C. elegans larvae through only two targets. doi.org/10.1371/jour... 1/n

Mentee sign-ups are open for the 2026-2027 C. elegans Community Mentor Match Program! Choose: - One-to-one mentoring with an experienced mentor - A peer-mentoring group with people at your career stage Or sign up for both, it takes just 2-5 minutes. And please spread the word! 🧵

Mentee sign-up for the C. elegans Community Mentor Match program

The 2026 cycle of the C. elegans Community Mentor Match is open to graduate students, postdocs, and faculty at any career stage. ⏱️ This form takes only 2–5 minutes to complete depending on your choic...

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How can a tiny worm shape a scientific career? Join 2026 GSA Mentorship Award recipient @irinakitop.bsky.social of @fredhutch.org on August 20 at 1:00 p.m. EDT as she shares how C. elegans has guided discoveries, collaborations, and approaches to mentorship. 🔗https://buff.ly/iUmQCCQ

How do developmental pathways adjust when harsh environments cause delays or interruptions in development? 🧪🧬 C. elegans can enter the stress-resistant and developmentally arrested dauer diapause stage. Progenitor cells actively maintain multipotency during dauer. 🧵

bioRxivpreprint@biorxivpreprint.bsky.social · 2w ago

FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer https://www.biorxiv.org/content/10.64898/2026.07.18.739353v1

Really excited about our new paper. The 2nd author Carlos Nava Cruz started as an UG, was supported by an diversity NIH supplement, & is completing his masters. C. elegans model for functional analysis of conserved ADPKD variants in cilia, EVs, & signaling academic.oup.com/genetics/art...

A C. elegans model for functional analysis of conserved ADPKD variants in cilia, extracellular vesicles, and sensory signaling

Abstract. Interpreting the pathogenic significance of missense variants in human disease gene candidates remains a major challenge in precision medicine. A

academic.oup.com

a key reason why generative AI might not be able to replace biologists. Other biologists might refer to metis as intuition, the deep knowledge that comes from knowing one's system, so that you know when and when not to follow an experimental lead: journals.biologists.com/jcs/article/...

The importance of indifference in scientific research

Summary: Martin Schwartz suggests a different approach to scientific ethics that looks at the scientific process from the inside.

journals.biologists.com

Jesse Rothstein@jrothst.bsky.social · 3w ago

Metis is, as he defines it, skill and knowledge earned by long practice that can’t be written down – e.g., how to navigate ships through the particular currents of a particular harbor. 3/6

Excited to share that in mid-August I'll be opening the Castillo–Quan Laboratory (CORA Lab) as a tenure-track Assistant Professor at Ohio University! We study stress responses, homeostasis & healthy aging in C. elegans. Recruiting two PhD students for Aug 2027. Join us @ohiouniversity.bsky.social!

After submitting your comment: CONTACT YOUR CONGRESSIONAL REPRESENTATIVES “Congress can override the rule through the appropriations process. They can write into statute a requirement to follow peer review and best scientific practices. In this way, Congress can stop the attacks on science.”

Sam Wang@samwang.bsky.social · 3w ago

To stop the Project 2025 takeover of science, public comments are half a plan. But they won't get us all the way there. Here's the second half of the plan - and what you can do: samwang.substack.com/p/building-h...

Job opportunity for a #postdoc in the Updike Lab: The Dustin Updike Lab at MDI Bio Lab uses #Celegans to investigate gene function in the germline, with a particular focus on epigenetic mechanisms that maintain germ cell identity. Apply: https://ow.ly/Mg6i50Zl5rN #sciencejobs #STEMjobs #postdocjob

🪱 A new mutant analysis reveals the functions of miRNA-producing small RNA pathway in #Celegans male fertility, sperm production, and gonad morphology. Learn more in #G3journal 🔗 buff.ly/Sc8hDzk

Worm friends 🪱 We need your video! Our C. elegans Mentor Match website has short videos from mentors and mentees sharing their experiences. Check it out, record your own video, and please share!

C. elegans Mentor Match Testimonials

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First paper from the Kasimatis Lab is now online! We investigate of the maintenance of mate plugging in C. elegans along with its function www.biorxiv.org/content/10.6...

A Male Expressed Copulatory Plug Increases Female Fertility in Caenorhabditis Nematodes

The genomes of self-fertilizing hermaphrodites offer a unique opportunity to probe why some genes with sex-specific functions are lost while others are maintained. In the androdiecious species, Caenor...

biorxiv.org

Do you want to support the next generation of C. elegans researchers? We are looking for mentors with C. elegans experience, including postdocs, faculty, and scientists outside academia, to share their knowledge and career advice with early career researchers. Sign up to become a mentor!

Mentor sign-up for the C. elegans Community Mentor Match program - 2026

Thanks for volunteering to be a Mentor! The 2026 cycle of the C. elegans Community Mentor Match is open to graduate students, postdocs and faculty at any career stage. This survey collects information...

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Hey C. elegans friends! What's your preferred method for cell-specific knockout or knockdown? Would love any paper recommendations too! Thank you!!!

For #Celegans researchers: want to capture better worm images? Our new paper explains how light scatters from the worm body and reveals practical strategies for improving imaging quality. Check out our new paper in iScience @cp-iscience.bsky.social: www.cell.com/iscience/ful...

This is the biggest threat to American science thus far, and that says a lot, I wrote--the template makes it easy to personalize. 🧪

Gregg Gonsalves@gregggonsalves.bsky.social · last mo.

OK, people. It takes 2 minutes to write a letter to Congress, a few extra if you personalize it. Russ Vought's attempt to take over ALL federal grant funding is anti-democratic and dangerous. We need MORE letters. Let's tip it over 2000 today. actionnetwork.org/letters/oppo...

The Central Michigan University contingent had a fantastic time at #wormtopicmeeting2026 in Madison! C. elegans meetings are the best

Best time to start Standing Up for Science was years ago. Second best time is NOW. 📣Leave public comment ☎️Contact Congress 🚨Register for the @standupforscience.net Emergency Science Meeting tomorrow at 4pm et ONE STOP SHOP: fight2win.standupforscience.net

Stand up for Science

Stand up for Science

fight2win.standupforscience.net

'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...

The controls that got out of control - EMBO Reports

EMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.

link.springer.com

🚨The OMB rule will be the end of science as we know it. MARK YOU CALENDAR for the @standupforscience.net EMERGENCY SCIENCE MEETING June 2nd, 4pm et. We will be giving an overview & assigning EVERY SCIENTIST IN AMERICA their marching orders. REGISTER: events.standupforscience.net/stand-up-for...

Emergency Science Meeting by Stand Up for Science

[discussing OMB-2026-0034?]

events.standupforscience.net

Hey worm people, if you have been a mentor or mentee in the C. elegans Mentor Match program, can you record a short video with advice to future participants? So far we have 3 videos, it would be nice to get to >20. Click on the link below to help us out!

C. elegans Mentor Match Testimonials

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I heard from several sources yesterday that NIH is planning to release a Request for Information (RFI) that apparently will include this: Scores and percentiles for NIH grant applications will not be shared with applicants although they will be provided to NIH program officers and staff. 1/3

Huh Kermit

ALT: Huh Kermit

static.klipy.com

👉️ Are you an undergraduate student interested in genetics? 👉 Do you want to learn how to read a research paper properly? 🪱 Read the #WormBase article in the May issue of #GENETICS, which provides a step-wise guide on understanding a #Celegans study. 🔗 buff.ly/fUkhQum

Worm friends, we need your help! For the next C. elegans Mentor Match cycle, we’re gathering testimonials from past mentors and mentees. One of our biggest challenges is recruiting new mentees, and hearing directly from past participants could really help. Please record a short video, and share!

C. elegans Mentor Match Testimonials

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Dearest shoalmates: Please consider posting a comment to the NIH regarding the Strategic Plan that includes reducing funding for animal research. Responses from the research community are currently greatly underrepresented compared w/ advocacy groups opposing animal experimentation. 🔗 below ⬇️ 1/2

Opening for a #postdocjob in modeling of #genetics of host- #microbiome interactions in #Celegans at @bcmhouston.bsky.social — take a look here: www.linkedin.com/jobs/view/44... Questions or apply via cover letter, CV, and references to bucks [at] bcm.edu . Hiring ASAP! #microsky #jobs 🦠🪱🧬

Download our updated database of postdoc fellowships from different foundations and agencies. We identified 275 fellowships. For each entry, we provide description of the fellowship, focus, amount, deadline, eligibility, etc. Download this database here: research.jhu.edu/rdt/funding-...

As one of the postdocs in my lab will be leaving to take a faculty position soon I will likely be placing a new ad in the coming week for someone with experience mapping C. elegans mutants from screens or doing bacterial genetics. If anyone knows/has candidates #Celegans #worms #bacteria #genetics

New paper from the lab. "Cap-adjacent 2′-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1". This thread explains the background to the paper and our key findings. doi.org/10.1093/nar/... 1/15

Cap-adjacent 2′-O-ribose methylation of RNA in C. elegans is required for postembryonic growth and germline development in the presence of the decapping exonuclease EOL-1

Abstract. Cap-adjacent 2′-O-ribose methylation (cOMe) of the first two transcribed nucleotides of RNA polymerase II transcripts is a conserved feature in m

doi.org

The Karp lab had a fantastic day at the Midwest C. elegans meeting last week with 6 undergrads and 3 grad students presenting. Thanks to @nickburton.bsky.social and the other organizers for all their work. It’s such a pleasure to get together and talk about science.