Yannick Alexandre
@yannick-alexandre.bsky.social
Immunologist at the Peter Doherty Institute, University of Melbourne. NHMRC Emerging Leader fellow Lymphoid tissue stromal cells and immunity
B cells trigger type I IFN production to promote T cell effector formation in response to high antigen exposure during chronic infection @cp-immunity.bsky.social @thedohertyinst.bsky.social @danielutzschneider.bsky.social @yannick-alexandre.bsky.social www.cell.com/immunity/ful...
Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳 url.au.m.mimecastprotect.com/s/NE67C6X1Py...
B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection
B cells are highly abundant lymphocytes and central players in humoral immunity. Although T cells are well known to support humoral responses, how B c…
url.au.m.mimecastprotect.com
Doherty Institute@thedohertyinst.bsky.social · last mo.New research reveals B cells do much more than produce antibodies - they also help activate and sustain T cells to fight chronic infections, like cancer or auto immune diseases. https://bit.ly/4wdXKrw
New research reveals B cells do much more than produce antibodies - they also help activate and sustain T cells to fight chronic infections, like cancer or auto immune diseases. https://bit.ly/4wdXKrw
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doherty.edu.au
Congratulations to our researchers who have been awarded over $11 million through the 2026 Australian Research Council (ARC) Discovery Project grants, recognising their leadership in advancing knowledge of the immune system, infection and human health. Find out more 🔗 https://bit.ly/43Dpjyx
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory www.science.org/doi/10.1126/...
I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
science.org
Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...
Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS
The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...
doi.org
Congratulations on this fantastic achievement @smguillaume.bsky.social and team!
Stephane Guillaume@smguillaume.bsky.social · last yr.So proud to have my first first-author paper out there in @pnas.org! Thanks so much to everyone involved, especially @linterman.bsky.social and @wsfoster.bsky.social for your support and guidance. Now onto the next one!!
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
science.org
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com www.nature.com/articles/s41...
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature
The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.
nature.com
🚨New paper alert! 🚨 Our latest work in @cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇 sciencedirect.com/science/arti...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…
sciencedirect.com
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer www.science.org/doi/10.1126/... @sciimmunology.bsky.social
Congratulations Daniel, Catarina and team for this beautiful study and huge accomplishment 👏🏼
Daniel Utzschneider@danielutzschneider.bsky.social · 2y agoExcited for our lab's FIRST paper #ScienceImmunology! 🎉 Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social Huge thanks to reviewers & @claireolingy.bsky.social 🙌 #Tpex #onthescoreboard www.science.org/doi/full/10....
