Tessera
Folgen

Alexandre Serafim

@2210alex.bsky.social

Pediatric Intensivist at Brasilia, Brazil

55 Posts576 Follower952 Folgt
NEJM.org@nejm.org · 4d ago

An antiviral therapy has not been approved for dengue. In a new report, mosnodenvir, a small-molecule antiviral, was shown to be protective in a human challenge model of dengue, and a weekly regimen provided adequate blood levels. Read the full report: https://nej.md/3VEGbnz

Chart showing Mosnodenvir plasma levels through Day 85 of a trial. A graph shows the mosnodenvir plasma concentrations through day 85 in the pharmacokinetic analysis.
Damien BARRAUD@damienbarraudmd.bsky.social · 6d ago

Des bisous aux experts français de la vasopressine 🤡. Venez à mes séances de bibliographie du jeudi : je vous réexpliquerez lentement que corrélation n'est pas causalité. Et aussi les problèmes causés par les conflits d'intérêt avec AOP Pharma... jamanetwork.com/journals/jam...

Vasopressin Initiation Threshold in Septic Shock

This large, pragmatic randomized clinical trial compares the effects of hospital-level strategies initiating vasopressin infusion at a lower- vs higher-dose threshold on septic shock outcomes in adult...

jamanetwork.com

BMJ Medicine@bmjmedicine.bsky.social · 2w ago

A new specialist review by Kendra Gilreath and colleagues summarises the pathogenesis of hypertrophic cardiomyopathy to help clinicians screen, diagnose, and improve the treatment of patients. Read now in BMJ Medicine: https://bit.ly/4y1o60k #Cardiology

Pathogenesis, screening, and diagnosis of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy is a common heritable heart disease. The disease is genetically, anatomically, and clinically heterogeneous. Hypertrophic cardiomyopathy is inherited in an autosomal domina...

bit.ly

Jocalyn Clark@jocalynclark.bsky.social · 2w ago

Op-eds from VIP types are tricky for medical journals. You don't often see a president & the WHO head co-authoring a piece in ... the NEJM. But here we have a commentary describing their efforts to coordinate #Hantavirus response & affirming the importance of solidarity and collaboration in health:

Hantavirus — Lessons Learned about Security and Solidarity | NEJM

Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity.

nejm.org

Nature Reviews Neuroscience@natrevneuro.nature.com · 2w ago

Sensing the skeleton: sensorineural regulation in bone — a Review by Zhao Li, Manyu Zhu, Neelima Thottappillil, Sowmya Ramesh & Aaron W. James #neuroscience #neuroskyence www.nature.com/articles/s41...

Sensing the skeleton: sensorineural regulation in bone - Nature Reviews Neuroscience

The skeleton is innervated by neurons that convey sensory information to the CNS and release neuroregulatory peptides to influence the bone microenvironment. James and colleagues describe the mechanis...

nature.com

Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 2w ago

Co-occurrence of Heterozygous Variants in PKD1 and ALG9 in a Patient With Early-Onset ESKD: A Case Report - Kidney International Case Reports www.kicasereports.org/article/S311... March issue highlights

Co-occurrence of Heterozygous Variants in PKD1 and ALG9 in a Patient With Early-Onset ESKD: A Case Report

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder, predominantly caused by pathogenic variants in the PKD1 and PKD2 genes. Variants in other genes, including ALG9, have eme...

kicasereports.org

Prof Gavin Yamey MD MPH@gavinyamey.bsky.social · 2w ago

Essential, brilliant reporting by @by-cjewett.bsky.social It's TERRIFYING: MAHA folks are INVESTIGATING pediatricians, who are some of the lowest paid docs in the professions, for vaccinating kids It's part of a 20-year anti-vaxx campaign by RFK Jr "that some of his political allies have joined"

Christina Jewett@by-cjewett.bsky.social · 2w ago

NEW: Ken Paxton's office is investigating pediatricians for vaccinating children. He alleged a sprawling profit-driven conspiracy. Pediatricians say the accusations are an attempt at intimidation. 🎁 www.nytimes.com/2026/10/05/h...

Jack Iwashyna@iwashyna.bsky.social · 2w ago

"Paired Spo2 measurements differed by ≥ 3% during 33% of monitored time (95% CI, 30%-35%) and by ≥ 5% during 13% of the time (95% CI, 12%-15%). The concordance correlation coefficient was 0.41, indicating poor agreement between paired Spo2 measurements." www.chestcc.org/article/S294...

Discrepancy Between Peripheral Oxygen Saturation Measurements Obtained Simultaneously From 2 Pulse Oximeters Made by Different Manufacturers in Acutely Ill Patients

Among adults hospitalized with acute hypoxemia, Spo2 values measured simultaneously by 2 pulse oximeters from different manufacturers differed by a clinically meaningful amount approximately one-third...

chestcc.org

NEJM.org@nejm.org · 3w ago

Duchenne muscular dystrophy, the most common childhood muscular dystrophy, with an estimated prevalence of 1 in 5000 boys 5 to 9 years of age, is a recessive degenerative disorder caused by variants in the dystrophin gene that lead to deficiency of dystrophin. Learn more: https://nej.md/4h7h0SP

An illustrated diagram of multisystem findings in patients with Duchenne Muscular Dystrophy. The image highlights physical features such as shoulder and arm positioning, a protruding belly, calf muscles with pseudohypertrophy, and a waddling gait. Annotations describe muscle weakness, respiratory challenges, positional deformity, and difficulty maintaining balance, leading to frequent falls.
ATS Blue Journal@atsblueeditor.bsky.social · 3w ago

Editorial: From mechanisms to clinical practice: introduction to an AJRCCM special section on interstitial lung disease #ILD academic.oup.com/ajrccm/artic... @atscommunity.bsky.social

From mechanisms to clinical practice: introduction to an AJRCCM special section on interstitial lung disease

This issue's special section on interstitial lung disease (ILD) spans the translational spectrum of ILD research, encompassing clinical practice guidelines

academic.oup.com

Stanford Neurology & Neurological Sciences@stanfordneuro.bsky.social · 4w ago

Biological age vs chronological age—what the science says. Tony Wyss-Coray, PhD explains that biological age reflects the body’s aging trajectory and functional health—not just calendar years. https://med.stanford.edu/news/insights/2026/09/biological-chronological-age.html

Biological age versus chronological age: What the science says

Stanford Health Care delivers the highest levels of care and compassion. SHC treats cancer, heart disease, brain disorders, primary care issues, and many more.

med.stanford.edu