Huisken lab is at #EED2026! @metteh-thorsager.bsky.social & @bekeloh.bsky.social will show how we use #Flamingo #light-sheet microscopy to address biological questions in the annelid #Platynereis, with imaging of the developing nervous system as an example (Platy Satellite Meeting & Poster P146).

These tools are valuable both as general cell membrane markers for tracking individual cells during development, and as a way to visualise nervous system formation. A great resource for the Platynereis community and beyond! 🧬 #lightsheet #Flamingo #developmental biology #platynereis

Happy to share our contribution to this new work led by @michalis-averof.bsky.social! @bekeloh.bsky.social and @metteh-thorsager.bsky.social tested membrane tags in the annelid Platynereis dumerilii — many reached the cell membrane, and several also label the developing nervous system in the larvae.

Michalis Averof@michalis-averof.bsky.social · 4mo ago

Finding molecular tags that localise fluorescent proteins to the cell membrane was the goal of our latest paper, now published in Development @dev-journal.bsky.social. The tags act as address labels, sending proteins to the cell membrane, where they highlight the shape and arrangement of cells. 2/9

Honored to have two images from our lab selected among the Top 5 Research Images of the Year in Göttingen 🎉 The images will be exhibited in Forum Wissen until 10 April 2026. www.forum-wissen.de/event/resear... #ForumWissen #ScienceIsAlsoArt

The image, which Mette (@metteh-thorsager.bsky.social) named “Democratising Imaging of Life in the Ocean,” features the salp Thalia democratica. It was captured with our portable Flamingo light-sheet microscope at @biodev-vlfr.bsky.social in collaboration with Alexandre Alié. #Salp #LBDV

Lisa’s picture (@lisma-ulb.bsky.social), named “Where Science meets Art,” shows a transgenic line of the annelid worm Platynereis dumerilii. These worms were kindly provided by Guillaume Balavoine (@balavoinelab.bsky.social). #PlatynereisDumerilii #Annelid Photo credit: Yourong Frank Wang

Being portable, we could bring the Flamingo light sheet microscope to the exhibition opening to explain how we captured the Salp image. This event shows that scientific research also reveals the beauty of the organisms we study. #LightSheet #LSFM #PortableMicroscope #Flamingo Photo credit: YF Wang

We advocate for model-guided, representative sampling and visualizations that make biological variation tangible.

Faster, clearer, deeper 3D imaging Researchers developed an innovative light sheet fluorescence microscopy platform, which means detailed scans of fine networks of nerves or blood vessels are possible faster: www.uni-goettingen.de/en/3240.html... #NatureBiotechnology: doi.org/10.1038/s415...

Lichtblattmikroskope erstellen 3D-Scans von Geweben und Organen – erzeugen bei großen Proben aber unscharfe Bilder. Forschende haben eine Plattform entwickelt, die diese Hürde überwindet. Mehr erfahren: www.uni-goettingen.de/de/3240.html... #MBexC #UMG @mbexc.bsky.social @huiskenlab.bsky.social

Absolutely loved this paper. Really addresses my personal gripes of not having isotropic voxel size in microscopy imaging rdcu.be/eRgYm

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Nature Biotechnology - A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

rdcu.be

Preprint alert! CochleaNet, our framework for analyzing light-sheet data of the cochlea. It consists of three networks to segment spiral ganglion neurons, inner hair cells, and to detect synapses. See rendering of a full cochlea in the image, find the preprint at doi.org/10.1101/2025....

Studying cochlear neuroanatomy demands imaging the entire cochlea at subcellular resolution. In our recent study (tinyurl.com/isotropicLSFM), we recorded the cochlea at isotropic resolution across the whole organ, laying the groundwork for what follows… #lightsheet #isotropic #cochlea

For technical details see the following post:

Huisken lab@huiskenlab.bsky.social · 9mo ago

Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social www.nature.com/articles/s41... #microscopy #lightsheet

Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊 Huge kudos to Max Hess for this PhD milestone! 💪 @lucaspelkmans.bsky.social shorturl.at/cO0u7 Let's zoom in!

I am happy to share a recent collaboration with @huiskenlab.bsky.social and @aakhte.bsky.social , who developed a great technique for performing fast and, above all, isotropic light-sheet microscopy. www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

nature.com

🎉 I am very glad to share that our paper on the rapid isotropic light-sheet microscope has just been published in Nature Biotechnology @natbiotech.nature.com. 🔗 Read the full article: www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

nature.com

www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

nature.com

Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social www.nature.com/articles/s41... #microscopy #lightsheet

Research Briefing: High-speed isotropic light-sheet microscopy www.nature.com/articles/s41... rdcu.be/ePWjG

High-speed isotropic light-sheet microscopy - Nature Biotechnology

Achieving uniform, isotropic sub-micrometer-resolution imaging at high speed across large, cleared tissues has been a major challenge for light-sheet microscopy. To address this, we developed a cost-e...

nature.com

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - @huiskenlab.bsky.social go.nature.com/4odcS49

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

go.nature.com

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy www.biorxiv.org/content/10.1...

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy

Modern biology increasingly depends on data-driven discovery, requiring scalable and affordable high-content 3D imaging across molecular to organ scales. Although tissue clearing, expansion microscopy...

biorxiv.org

Our image of a sea squirt oozoid (Thalia democratica) was selected as an Image of Distinction in Nikon Small World. Imaged with the Flamingo microscope by @metteh-thorsager.bsky.social at @biodev-vlfr.bsky.social in Villefranche-sur-Mer. Salp sample courtesy of Alexandre Alie. nikonsmallworld.com/

The future of High-Content Imaging has arrived. -> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective! See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...

Huisken lab is attending Göttingen Cognition Forum: Curiosity & Interaction. Learn about our research... @spp2205.bsky.social @sfb1528.bsky.social @rtg2906-curiosity.bsky.social @uni-goettingen.de events.gwdg.de/event/1099/

The Göttingen Cognition Forum: Curiosity & Interaction

We are pleased to announce the First Göttingen Cognition Forum: Curiosity & Interaction The conference brings together researchers from neuroscience, psychology, behavioral biology, computational scie...

events.gwdg.de

Postdoc opportunity in the Averof lab: a crustacean meets a flamingo—not on the menu, but in the light sheet. Track the origins of cells during leg regeneration in Parhyale hawaiensis using light sheet microscopy. Excited to be part of this interdisciplinary project. Details on how to apply below.

Michalis Averof@michalis-averof.bsky.social · 10mo ago

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale apply here: www.averof-lab.org/pages/tracman 1/3

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 11mo ago

Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1

The Huisken lab is now on Bluesky @huiskenlab.bsky.social - follow us for updates on our activities!

We brought our Flamingo microscope to the light sheet microscope course in Dresden (#LISH25). We captured extensive time-lapse recordings and are excited to share highlights from our experiments with Hydra and Zebrafish.