Aura Carreira
@acarreiralab.bsky.social
Scientist interested in genome integrity maintenance mechanisms and cancer
Drawing the mind, one neuron at a time: A 2022 book walks readers through the life and work of Santiago Ramón y Cajal, the Spaniard whom many consider the founder of modern neuroscience. Check out the Science Books Review on #ReadABookDay: https://scim.ag/4rbS1kR
How long does DNA damage last? @aaronquinlan.bsky.social and I found evidence that lesions are transmitted from parent (P0) to offspring (F1) in C. elegans. If they segregate unrepaired for multiple cell divisions, lesions generate multi-allelism in the F1 germline. www.biorxiv.org/content/10.6...
Inherited DNA damage generates multi-allelic mutations in C. elegans
Exogenous and endogenous mutagens generate a wide variety of DNA lesions, including bulky adducts, chemical modifications, and single- or double-stranded breaks. A phenomenon called “lesion segregation,” in which lesions evade repair and persist for multiple cell divisions, has recently been documented in tumors and healthy somatic tissues from mice and humans, respectively. Persistent lesions can generate multi-allelic variants (MAVs) by serving as templates for multiple rounds of error-prone replication. By reanalyzing data from a large C. elegans mutagenesis experiment, we observed robust evidence for MAVs at a small fraction (∼0.2%) of mutated sites in the offspring of strains treated with alkylating agents. Because these sequencing data were derived from the progeny of a single F1 animal — itself the offspring of a mutagenized P0 — all mutations should be biallelic. The presence of multi-allelic variation implies that some DNA lesions are transmitted to the F1 zygote, evade repair, and are repeatedly bypassed by error-prone polymerases during embryogenesis. We suspect that many more lesions are inherited than is suggested by MAV prevalence, and that a large fraction of biallelic mutations are also caused by inherited lesions. Our results demonstrate that DNA lesions serve as durable, transgenerational templates for mutagenesis in C. elegans . We speculate that lesion segregation in the early embryo may be a source of mosaicism and genetic diversity in humans, as well. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, R01HG012252
biorxiv.org
🔬 Septiembre es el mes de la investigación en cáncer. El 24 de septiembre celebramos el #WorldCancerResearchDay y durante todo el mes acercaremos la investigación a la sociedad. Porque investigar es avanzar hacia el 70 % de supervivencia. 💚 #TodosContraelCancer
Un día como hoy de 1992 murió la botánica #BarbaraMcClintock🌽, #Nobel 1983 por su rompedor hallazgo: los #transposones. Reflexión de Ernesto Sánchez @cbm-csic-uam.bsky.social sobre aceptar nuevas ideas: https://f.mtr.cool/0jfbvx1igd
🔬 ¿Cómo distinguir información científica rigurosa de mensajes confusos? @lluismontoliu.bsky.social y @perestupinya.bsky.social compartirán claves para comunicar y comprender mejor la ciencia. 🔗 https://f.mtr.cool/7ec93thtsb
Let's begin the 2026 Fall Season of GIIN Seminars! 🍂 Join us live on Tuesday, September 1st at 5pm (Rome) / 11am (NYC) for an exciting webinar featuring @chiololab.bsky.social o and Jean-Yves Masson! Zoom link: uzh.zoom.us/j/6598481621...
‼️🚨Out now in Molecular Cell - Our latest study 𝐫𝐞𝐯𝐞𝐚𝐥𝐢𝐧𝐠 𝐧𝐞𝐰 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐅𝐀𝐂𝐓 𝐟𝐮𝐧𝐜𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐧𝐮𝐜𝐥𝐞𝐨𝐬𝐨𝐦𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐚𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝟑𝐝 𝐠𝐞𝐧𝐨𝐦𝐞 𝐦𝐚𝐢𝐧𝐭𝐞𝐧𝐚𝐧𝐜𝐞: tinyurl.com/2xctvx38. It was a pleasure to lead this collaborative effort alongside @nilskrietenstein.bsky.social More in🧵below 🪡
Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin
Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replica…
tinyurl.com
Hoy, como parte de nuestra sección de científicos ilustres, que dejaron su huella en Madrid, nos detenemos en Severo Ochoa. Destacado especialmente en el campo de la biología molecular, que en Madrid da nombre al Centro de Biología Molecular Severo Ochoa (CBM) @cbm-csic-uam.bsky.social
FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity
FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity
Wang et al. uncover a non-canonical role for FANCA in safeguarding genome stability during DNA replication. FANCA recruits the flap endonuclease FEN1 to lagging strands to suppress transcription-replication conflicts, a function that becomes essential under oncogene-induced replication stress, rendering tumors vulnerable to PARP inhibition despite intact homologous recombination repair.
dlvr.it
Online Now: Coordination of ALT telomere maintenance across the cell cycle Online now:
Coordination of ALT telomere maintenance across the cell cycle
Alternative lengthening of telomeres (ALT) counteracts telomere shortening independently of the activity of the enzyme telomerase. ALT uses telomere sequences for recombination-based telomere extension, and recent work has started to reveal how this pathway works across the cell cycle and even across cell divisions.
dlvr.it
🙏 El #CSIC está profundamente agradecido a Juana y a todas las personas que destinan sus bienes a la ciencia 🔬 Sus aportaciones contribuyen al progreso científico y nuevos avances Conoce la historia de Juana Rienda, en el #eldiarioes 👉
El CSIC homenajea a Juana Rienda y crea unas ayudas con los 830.000 euros que dejó a la ciencia en su testamento
El Consejo Superior de Investigaciones Científicas crea las ayudas extraordinarias “Juana Rienda” para proyectos de investigación en enfermedad de Alzheimer y de Parkinson, tal y como ella deseaba
tiny.cc
🧬🧬🧬It’s all in your DNA: damage in the DNA accumulates and drives aging. Could mending damaged DNA prolong life? News featuring the DREAM master regulator of DNA repair today in @Nature www.nature.com/articles/d41...
Could mending damaged DNA prolong life?
Inspired by long-lived animals — and human centenarians — researchers are hunting for ways to enhance DNA repair and extend healthspan.
nature.com
Using a risk assessment tool researchers at @cam.ac.uk and @icr.ac.uk have found that NICE referral criteria miss up to 95% of women under 50 who go on to develop breast cancer within 10 years. 🔗 zurl.co/6NNxS @cancerresearchuk.org @breastcancernow.bsky.social
Amazing structures, and distinct binding modes, of TOPBP1 or ETAA1 activating the ATR-ATRIP kinase by an allosteric mechanism. In NSMB from Pavletich lab: www.nature.com/articles/s41...
Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase - Nature Structural & Molecular Biology
Li et al. present cryo-EM structures of the ATR–ATRIP complex bound to the ATR-activating domains of TOPBP1 and ETAA1; these reveal distinct binding modes and allosteric mechanism of activation for TO...
nature.com
Working with a hugely engaged group of editors (all of whom are practising scientists), authors and reviewers, and a great publisher, is a hugely rewarding way to contribute to the community. Your chance to get involved!
Nucleic Acids Research@narjournal.bsky.social · last mo.📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...
New Online! Structure and function of the centromere and inner kinetochore
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology, Published online: 03 August 2026; doi:10.1038/s41580-026-00989-7The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review discusses recent advances in determining the organization of centromeric chromatin and the complete structure and function of the inner kinetochore, which are crucial for accurate chromosome segregation.
dlvr.it
These two reviews on centromeres and kinetochores in @natrevmcb.nature.com cap off @andrea-musacchio.bsky.social sabbatical at @stanfordbiochem.bsky.social from @valleefoundation.bsky.social. Long time in the making! Non-paywall versions rdcu.be/fxD9V, rdcu.be/fxEar
Structure and function of the centromere and inner kinetochore
Nature Reviews Molecular Cell Biology - The kinetochore is a macromolecular complex that assembles on centromeric chromatin and connects spindle microtubules to the chromosome. This Review...
rdcu.be
🧬🌍 Hoy 1 de agosto, Día Mundial del ARN, recordamos que sin ARN no hay vida, y que la ciencia que es básica hoy es la que cambia el mundo mañana. En 1959, Severo Ochoa, uno de los fundadores del CBM, ganó el Premio Nobel por descubrir cómo se sintetiza el ARN #worldARNday @csic.es @uam.es
Thrilled to share our new preprint showing that TopBP1 condensates orchestrate nuclear actin remodeling during replication stress, thereby linking stress signaling, nuclear envelope organization, and genome stability. Led brilliantly by our former PhD student Elia Moarbess ! lnkd.in/g4UFD_MM
Activists briefly interrupted the opening ceremony of the 26th annual International AIDS Conference to protest the lack of access in Latin America to lenacapavir, a new long-lasting drug that prevents HIV infection. Learn more: https://scim.ag/4vZ2kJF
Through a fantastic collaboration with @mariasecrier.bsky.social we show how dormant breast cancer cells occupy protected niches, presenting a therapeutic challenge. Congratulations to @cenkcelik.bsky.social for a super study
MRC Laboratory of Medical Sciences@mrc-lms.bsky.social · last mo.A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment. Understanding these hideouts could lead to new drug targets🧬 @mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
Science funding has still not reached gender equality: "Projects led by male PIs received roughly twice the mean funding compared to female PIs." www.sciencedirect.com/science/arti...
🏅 Cuatro investigadores del #CSIC reciben los Premios Nacionales de Investigación 2026, concedidos por el Ministerio de Ciencia, Innovación y Universidades 🏆 Crisanto Gutiérrez Armenta, Jesús Martínez de la Fuente, Pablo Alonso González y Ana Novoa Pérez ¡Enhorabuena! 👉 http://tiny.cc/xvl7101
🏆 El investigador del CBM Crisanto Gutiérrez recibe el Premio Nacional de Investigación Santiago Ramón y Cajal en el área de Biología. Merecido reconocimiento a una trayectoria científica de excelencia y a sus contribuciones fundamentales a la biología molecular. www.cbm.uam.es/index.php/20...
El investigador del CBM Crisanto Gutiérrez recibe el Premio Nacional de Investigación Santiago Ramón y Cajal de Biología - Centro de Biología Molecular Severo Ochoa
El investigador del Centro de Biología Molecular Severo Ochoa (CBM, CSIC-UAM) Crisanto Gutiérrez ha sido distinguido con el Premio Nacional de Investigación Santiago Ramón y Cajal, en el área de […]
cbm.uam.es
Sigue abierto el registro para el Simposio. No os perdáis la oportunidad de asistir y compartir vuestra ciencia. ¡Os esperamos!
Centro de Biología Molecular Severo Ochoa@cbm-csic-uam.bsky.social · 2mo ago📢 Ya está abierto el plazo de inscripción para el II Chromatin Alterations in Cancer Development Symposium, que se celebrará el 28 de septiembre en el CBM. Organizado por nuestros investigadores Ana Ortega y Emilio Lecona. 🗓️ Deadline para inscribirse: 9/9/26 www.cbm.uam.es/index.php/ev...
Nature research paper: Genetic background sets the trajectory of experimental cancer evolution go.nature.com/3RzmnjJ
Genetic background sets the trajectory of experimental cancer evolution - Nature
Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stages of cancer development.
go.nature.com
Congrats rodrimartinr.bsky.social on your great thesis defense. Thanks to María Villa, AnnaMaria Ruggiano and Jim Sutherland for the work as Thesis Committee. Rodrigo is the first PhD from the lab, we cannot be prouder of his great work. All the best in your future career! @cbm-csic-uam.bsky.social
Congrats @rodrimartinr.bsky.social on your great thesis defense. Thanks María Villa, AnnaMaria Ruggiano and Jim Sutherland for their work as Committee. Rodrigo is the first PhD from the lab, we cannot be prouder of his great work. All the best in your future career! @cbm-csic-uam.bsky.social
mtDNA deletions cause incurable diseases. Our CRISPR screen found a fix: deleting MTERF1 restores mitochondrial function, not by clearing bad genomes, but by making the healthy ones work harder. Simple Biology! New preprint 👇 @tatakavlashvili.bsky.social www.biorxiv.org/content/10.6...
MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation
Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurable mitochondrial pathologies. Using a genome-wide C...
biorxiv.org
Our manuscript on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1 is finally out in @genesdev.bsky.social. Big thanks again to the Min, Lazzerini Denchi and @cejkalab.bsky.social labs! @angelotaglialatela.bsky.social genesdev.cshlp.org/content/earl...
SMARCAL1 is a candidate therapeutic target for ALT-positive tumors
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
Alberto Ciccia@albertociccia.bsky.social · 7mo agoHappy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...
