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AJ te Velthuis

@ajtevelthuis.bsky.social

Assistant Professor at Princeton University. RNA polymerases, RNA viruses, mutations, and innate immune responses. Funded by NIH, Wellcome, NSF. https://tevelthuislab.scholar.princeton.edu

14 Posts306 Follower204 Folgt
Cameron Myhrvold@cambearon.bsky.social · 4mo ago

RNA is more challenging to search through than DNA as there are so many RNA molecules in a cell. Also, RNAs are very heterogeneous in length, flexible, and structured. So we wondered: how can RBPs efficiently find their targets amid a sea of other RNAs? www.biorxiv.org/content/10.6... (2/26)

Intersegmental transfers drive target search in an RNA-targeting CRISPR system

Sequence-specific RNA-binding proteins (RBPs) must efficiently locate their targets among a multitude of cellular RNAs. Cas13, an RNA-guided CRISPR protein, represents an ideal model system in which t...

biorxiv.org

AJ te Velthuis@ajtevelthuis.bsky.social · 7mo ago

Transient RNA structures play a key role in the emergence of highly pathogenic avian influenza viruses! Great to see this collaboration with Mathis Funk, Mathilde Richard, Stephen Cusack, and others in @science.org www.science.org/doi/10.1126/...

Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis

Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...

science.org

Karishma Bisht@karishmabisht.bsky.social · last yr.

Excited to share our latest preprint in which we integrate mathematical modeling with experimental approaches to investigate how ⬆️ temperature influences aberrant RNA synthesis and innate immunity in flu infection 🦠

AJ te Velthuis@ajtevelthuis.bsky.social · last yr.

Flu infection => temperature⬆️ => NP levels⬇️ => aberrant RNAs⬆️ => interferon⬆️. Elegant modeling and experimental work by @karishmabisht.bsky.social and @danielweilandt.bsky.social! Preprint: www.biorxiv.org/content/10.1...

Larry Ladd@larryladd.bsky.social · 2y ago

We are at risk of abandoning “a deal where the government provides funding, and in exchange it gets products, research, national security, prestige, and the next generation of qualified scientists.” #academicsky www.princeton.edu/news/2025/02...

The partnership that drives America’s leadership in medical discovery: How it works and what’s at stake

With federal support, universities produce world-changing discoveries and the next generation of exquisitely well-trained researchers.

princeton.edu

derek guy@dieworkwear.bsky.social · 2y ago

FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.

Drawing of Benjamin Frankling wearing a coonskin cap. Franklin being received by the French court in 1778. The French are in powdered wigs.
Alistair Russell@alistairrussell.bsky.social · 2y ago

Despite everything, I still really want to celebrate the wonderful folks in my group, so I hope it is ok if i write about our latest work. I am very proud of all the authors, and our collaborators, on our work just published in Nature communications. www.nature.com/articles/s41...

Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter - Nature Communications

The eight genomics segments of Influenza A virus exhibit different replication dynamics during infection. Here, the authors show through a range of mutant libraries of HA and PB1 segments that Influen...

nature.com

AJ te Velthuis@ajtevelthuis.bsky.social · 2y ago

Excited to share this new preprint showing that non-canonical influenza virus transcripts are produced in a sequence/RNA structure-dependent manner on aberrant RNAs: www.biorxiv.org/content/10.1...

A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs

Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...

biorxiv.org

Nonia Pariente@npariente.bsky.social · 2y ago

What we are waiting for to wake up? "The patient had been in contact with sick and dead birds in backyard flocks, the Centers for Disease Control and Prevention said" @adamjkucharski.bsky.social discusses effective outbreak response @plosbiology.org plos.io/3ZnpcnE apnews.com/article/bird... 🧪

Health officials say Louisiana patient is first severe bird flu case in US

A person in Louisiana has the first severe illness caused by bird flu in the U.S., health officials said Wednesday.

apnews.com

Alistair Russell@alistairrussell.bsky.social · 2y ago

(this is very consistent with another work from @ajtevelthuis.bsky.social which we were happy to contribute to, found at www.biorxiv.org/content/10.1...)

Influenza A virus transcription generates capped cRNAs that activate RIG-I

During influenza A virus (IAV) infection, host pathogen receptor retinoic acid-inducible gene I (RIG-I) detects the partially complementary, 5’-triphosphorylated ends of the viral genome segments and ...

biorxiv.org