Here is the study by @joyjoychoi.bsky.social from the Brockdorff lab I mentioned, who analysed the inactive X chromosome in ES cells - with some beautiful STA of nucleosomes

Joy Jeongyoon Choi@joyjoychoi.bsky.social · yesterday

Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8

Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8

How do epithelial cells make a lumen as they polarize? We have some exciting new answers to this long standing question. Check out our new paper in which we show that lumen initiation is driven by large vacuoles that deliver a pre-assembled apical cortex to the AMIS: www.nature.com/articles/s41...

Bulk delivery of a preassembled apical surface initiates epithelial lumen formation - Nature Communications

Epithelial lumen formation is fundamental to organ development, yet how apical surfaces first emerge remains unclear. Ghosh, Martin, and Chen et al., show that lumen initiation is driven via bulk deli...

nature.com

Check out our new preprint in which we used cryoCLEM to study the native architecture of the human inactive X chromosome in RPE1 cells. Neil Brockdorff’s group from Oxford posted a similar story, performed in female stem cells. We see individual nucleosomes and other exciting things!

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 5d ago

Native in situ architecture of the human inactive X chromosome revealed by correlative light and electron microscopy https://www.biorxiv.org/content/10.64898/2026.09.04.749547v1

Super happy to announce that our paper "Homer condensates orchestrate YAP–Wnt signaling crosstalk downstream of the Crumbs polarity complex" is now out in PNAS: doi.org/10.1073/pnas.... We thank the reviewers for their constructive feedback and PNAS for a smooth revision!

Register and submit your abstract here. www.ntu.edu.sg/sbs/symposiu... 7-9 Dec 2026, School of Biological Sciences, NTU Singapore. Come join us. #StructuralBiology #CellBiology #SBS2026

SBS 2026

ntu.edu.sg

NTU's School of Biological Sciences is hiring faculty, Assistant Professor to Full Professor. The environment is collaborative and the start-up funding is genuinely generous. Four research areas. Campus visits 28 Sep to 2 Oct 2026. Apply here www.ntu.edu.sg/sbs/about-us...

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

So proud of everyone on this team!

Journal of Cell Biology@jcb.org · 3mo ago

Shi, Manzi, Grater, @nityak123.bsky.social, Ohler, de Jesus, & Dickinson show that in polarizing epithelial spheroids from mouse embryonic #StemCells, ZO-1 clusters are transported by cortical #actin flows to establish the apical junction. rupress.org/jcb/article/... #Myosin #Cytoskeleton #Polarity

Spotlight: New work by Zheng et al. (rupress.org/jcb/article/...) elucidates how #adhesion proteins are rapidly moved along the cell edge to vertices in response to mechanical forces. Jiarui Jiang and @krothphd.bsky.social discuss the findings: rupress.org/jcb/article/... #Mechanobiology

Happy to announce that the 2027 EMBO Cell Polarity and Membrane Dynamics workshop will be a reality! Big thanks to @embo.org for funding it and of course to Alex @alexludwig.bsky.social and Diana @dianapinheiro.bsky.social, it'll be fun :) Stay tuned and save the dates! coming-soon.embo.org/w27-32

Thank you Alf Honigmann and @biotec-tud.bsky.social for hosting me! It was great hanging out and meet people from @poldresden.bsky.social and @mpi-cbg.de.

Bye bye Munster! It was great to be back! Next up: the Imaging Cell Dynamics JCS2026 meeting in Spain.

Leaving the jungle behind for 4 weeks around Europe—labs, talks, workshops, and a conference. First stop: Münster @uni-muenster.de. Big thanks to Stefan @luschnig.bsky.social for the kind invite! Looking forward to catching up with colleagues and friends and meeting new folks along the way.

🎉 A huge milestone for Dresden and the wider biophysics community! 🔬The Center for the Organization of Living Matter (COLM) at TUD will become the new home of PoL, and starts construction in 2027. This new building will be purpose-built for novel and interdisciplinary collaborations!

TU Dresden@tudresden.bsky.social · 5mo ago

Neubau für Erforschung der Grundlagen des Lebens: 🧬 @wissenschaftsrat.de hat die Förderung eines neuen Gebäudes für die #TUDresden empfohlen. Das Exzellenzcluster @poldresden.bsky.social bekommt eine herausragende Forschungsinfrastruktur, um die Grundlagen des Lebens zu ergründen. ℹ️ tud.link/vhazar

We're hiring at NTU SBS, Singapore. Tenure-track faculty position in Biomedical Data Science (computational biology, AI in biology, bioinformatics). Great infrastructure, great place to do science. Please share. apply.ap1.interfolio.com/119013

Good news from the ALab. We have just resubmitted our revised manuscript on the role of Homer proteins in YAP-Wnt signaling crosstalk. Here's the updated preprint: doi.org/10.1101/2025.... We’re truly grateful to the reviewers for their thoughtful comments and questions and hope they'll be happy...

James, J., Winn, L. B., Mottram-Epson, P., & Köster, D. (2025). Paths to stability–actin regulation of adherens junction mechanics. Journal of Cell Science, #EpitheilalMechanicsReview doi.org/10.1242/jcs....

An Archaea bacterium with an internal membrane system! Amazing and beautiful work!

Tanmay Bharat@tbharat-lab.bsky.social · 10mo ago

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Epithelial tension controls intestinal cell extrusion

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

science.org

Supracellular actomyosin assemblies: master coordinators of development In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties journals.biologists.com/dev/article/...

Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!

Guillaume Thibault@gthibault.bsky.social · last yr.

📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!

We have some news! We find that the post-synaptic Homer proteins coordinate YAP and Wnt signaling in epithelial cells, downstream of the Crumbs polarity complex. They do so by sequestering YAP and beta-catenin in biomolecular condensates, and by suppressing a FRYL/NDR complex. Check it out!

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.

Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex https://www.biorxiv.org/content/10.1101/2025.07.23.666266v1

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio meetings.embo.org/event/26-org...

Intracellular mechanics and organelle mechanobiology

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

meetings.embo.org

EMBO Cell Polarity and Membrane Dynamics workshop is off to a good start - as always :) #EMBO

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

Tambrin et al. show that the Cdc42/Rac GAP ARHGAP12 promotes the flux of macromolecules across tight junctions by suppressing junctional actin assembly and tension via N-WASP and the Arp2/3 complex. T...

cell.com

journals.biologists.com/jcs/article/...

Science under siege: protecting scientific progress in turbulent times

As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

journals.biologists.com

We have some exciting news about how epithelial cells initiate an apical lumen de novo, and how this is coordinated with cell-cell junction formation. Check it out: www.biorxiv.org/content/10.1...

Bulk exocytosis of large intracellular apical precursor organelles establishes apical domain identity during de novo lumen formation

The creation of a microvilli-rich apical luminal domain is a key event in the development of epithelial tissues. De novo lumenogenesis, in which epithelial cells establish apical identity by directing...

biorxiv.org

Another beautiful tight junction. This time with scale bar :)