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Alfie Wearn

@alfiewearn.bsky.social

Research Associate at The Montreal Neurological Institute 🧠 | Studying Alzheimer's disease pathogenesis with neuroimaging | OHBM Communications Committee @ohbm-com.com | He/Him

18 Posts132 Follower89 Folgt
Alfie Wearn@alfiewearn.bsky.social · 5mo ago

Neuromodulatory neurons are extremely susceptible to stress. I argue that their fragility is an inherent weak point, the breaking of which directly leads to Alzheimer’s Disease. I discuss this idea and its implications in a recently published perspective piece: dx.doi.org/10.1002/alz....

The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis

Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factor...

dx.doi.org

Alfie Wearn@alfiewearn.bsky.social · 5mo ago

Neuromodulatory neurons are extremely susceptible to stress. I argue that their fragility is an inherent weak point, the breaking of which directly leads to Alzheimer’s Disease. I discuss this idea and its implications in a recently published perspective piece: dx.doi.org/10.1002/alz....

The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis

Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factor...

dx.doi.org

Alfie Wearn@alfiewearn.bsky.social · 9mo ago

We just published a paper in PNAS, showing microstructural changes to the hippocampus in aging and presymptomatic Alzheimer's disease - in humans, in vivo. We continue to show the value of structural MRI beyond simply measuring large-scale atrophy! Read here: ow.ly/1NvV50XkXnX

Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer’s disease pathology | PNAS

Hippocampal degeneration is a feature of both normal aging and Alzheimer’s disease (AD). Prior to macroscopic degeneration, microstructural changes...

ow.ly

Proceedings of the National Academy of Sciences@pnas.org · 9mo ago

The search for early signs of Alzheimer's disease continues: Brain scans reveal microstructural changes in the hippocampus that signal early stages of the disease, including demyelination, increased iron deposition, and changes in water content. In PNAS: https://ow.ly/1NvV50XkXnX

Heat maps for each of the five measures of structure mapped to the folded and unfolded surfaces of bilateral hippocampus, averaged across all participants. Cytoarchitectonic subfield boundaries are shown for reference.
Nature Methods@natmethods.nature.com · 10mo ago

HippoMaps: an open-source resource for studying the human hippocampus at different scales and with different modalities. www.nature.com/articles/s41... @jordandekraker.bsky.social @borismontreal.bsky.social @jclauneuro.bsky.social @neuroak.bsky.social @sofievalk.bsky.social @donnagift.bsky.social

HippoMaps: multiscale cartography of human hippocampal organization - Nature Methods

HippoMaps provides an open-source resource for studying the human hippocampus at different scales and with different modalities such as histology, fMRI, structural MRI and EEG.

nature.com

Kevin Sitek@sitek.bsky.social · 11mo ago

Healthy scientific communities—built on open, engaged communication—are ready to take on the next challenges facing broader society. Had a blast writing this piece with @dupre.science and @alfiewearn.bsky.social. Many thanks to the other past @ohbm-com.com chairs for their feedback and support!

Aperture Neuro@apertureohbm.bsky.social · 11mo ago

Kicking off the Future of Scientific Publishing Special Issue, former @ohbm-com.com Chairs highlight the importance of effective science communication: doi.org/10.52294/001... @sitek.bsky.social @alfiewearn.bsky.social @dupre.science @ohbmofficial.bsky.social

The Transmitter @thetransmitter.bsky.social · last yr.

Our award-winning news team is looking for an enthusiastic trade journalist to join our fast-paced newsroom in NYC. This is an excellent opportunity for a science journalist to develop a beat in the field of neuroscience. For more info, please visit: bit.ly/4nvAy4k #neuroskyence

Reporter, The Transmitter

The Transmitter offers up-to-date news and analysis of the field of neuroscience and is dedicated to helping scientists at all career stages stay current and build connections. Our award-winning news ...

simonsfoundation.wd1.myworkdayjobs.com

Vincent Breton-Provencher@vincentbp.bsky.social · last yr.

My laboratory at Université Laval in Québec City, Canada, is looking for a postdoc to study how neuromodulatory systems impact cortical processing during foraging behavior. This fully-funded position offers a collaborative environment in a great city. More info👇 can-acn.org/postdoctoral...

Postdoctoral position available in the Breton-Provencher Lab at Université Laval to study neuromodulatory systems and foraging behavior – Canadian Association for Neuroscience

can-acn.org

Gc Rox@gcrox.bsky.social · last yr.

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

John Anderson 🇨🇦@janderz8.bsky.social · last yr.

I have an opening for a graduate student at @carleton.ca (Carleton University) in the Department of Cognitive Science for fall 2025. Project is a multimodal MRI study examining how Hearing Loss affects cognition in older adults - contact me with a CV if you’re interested & have relevant expertise!

Mallar Chakravarty@mallarchak.bsky.social · last yr.

There's a stream of excellent papers in @apertureohbm.bsky.social being published! Check them out: apertureneuro.org Submit your own +code +data +open science +imaging studies+ Quick turnaround, a devoted ed board, and lowest APC around. And you'll support @ohbmofficial.bsky.social share pls!

Aperture Neuro

Enables a diverse approach to sharing and communicating high quality, community-based, open neuroscience research.

apertureneuro.org

Aperture Neuro@apertureohbm.bsky.social · last yr.

Zhang and Tremblay investigate age-related changes in resting-state functional connectivity among amateur singers, instrumentalists, and active controls: doi.org/10.52294/001... @fmri-today.bsky.social @mallarchak.bsky.social @ohbmofficial.bsky.social

Kelton Minor@keltonminor.bsky.social · last yr.

There are days in life that shake you. I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University & academic career... 1/🧵

Bild
Alfie Wearn@alfiewearn.bsky.social · last yr.

I was privileged to collaborate with the brilliant Stéfanie Tremblay on her project, just published in Neurobiology of Aging: Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease bit.ly/3Rb3QWW

Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease

Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming…

bit.ly

Andrea Stocco@andreastocco.com · last yr.

The network of Alzheimer's Disease Research Centers is one of the most amazing NIH projects of all time: 33 sites collaborating to fight Alzheimer's in the lab and in the clinic at the same time. All of it in turmoil because the new funding is blocked.

Tim Verstynen@tdverstynen.bsky.social · last yr.

Alzheimer’s disease will bankrupt the US healthcare system in 20 years if we don’t find better therapies now. The Trump administration is choking the largest national research collective on it. If Alzheimer’s has touched your life, raise some hell. www.baldwin.senate.gov/news/press-r...

BWJones@bwjones.bsky.social · last yr.

By @katherinejwu.com "The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,” The NIH is in a struggle for its (and our) lives. This is existential to America:

Inside the Collapse at NIH

Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.

theatlantic.com

L.D. Burnett@ldburnett.bsky.social · last yr.

for pity’s sake, I am BEGGING university leaders to stop framing this issue in terms of what this will cost the university. people dont care! EXPLAIN WHAT THIS WILL COST THE PUBLIC: closed hospitals and clinics, skipped treatments, loss of access to experimental drugs, unemployment, recession

sreenshot from the new york times reporting that Stanford University’s provost is talking about how the loss of funding from national institutes of health funding will cost the university $160 million. that’s not the way to get this changed — the people think “stanford is rich; no big deal.” leaders need to talk about what this will cost the public
OHBM Communications Committee (ComCom)@ohbm-com.com · last yr.

New blogpost from our OHBM 2024 award winner series! 🧠 Dr. Rosanna Olsen @rosannaolsen.bsky.social, winner of the 2024 Diversity and Inclusivity Champion Award, reflects on her vision for a more inclusive scientific community. Read here: www.ohbm-com.com/blog/55ubbep...

Interview with Dr. Rosanna Olsen, 2024 Winner of the Diversity & Inclusivity Champion Award — OHBM Communications

Author: Ashley Tyrer Editor: Simon R. Steinkamp

ohbm-com.com

Stephen Curry@scurry.bsky.social · last yr.

Now over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...

Open letter to the President of the Royal Society – time to stand up for your values

If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...

docs.google.com

Stephen Curry@scurry.bsky.social · last yr.

Letter expressing widespread concern at the Royal Society’s inaction over Musk reported in the Mirror: www.mirror.co.uk/news/uk-news...