My first paper has been published in Hippocampus! bsky.app/profile/masa... Thank you Caswell and Claudia for your support!

Caswell Barry@caswell.bsky.social · 3d ago

Masa's paper is out in Hippocampus. The left-right alternation of hippocampal theta sequences at T-maze choice points, much loved as a 'planning' signal, falls straight out of MEC dynamics. Well done @masahironakano.bsky.social, fun project with @clopathlab.bsky.social doi.org/10.1002/hipo.70131

For 30 years, neuroscientists have argued about whether theta sweeps are just passive sensing, or something closer to planning. So which is it? #neuroskyence By @natmesanash.bsky.social www.thetransmitter.org/memory/new-f...

New findings begin to resolve theta sweep debate

Theta sweeps have been mired in controversy for decades, but the emerging consensus view suggests that they function in attention and goal direction.

thetransmitter.org

Out now in @science.org : How does the brain rapidly scan space to guide navigation? We found that the brain’s internal map is continuously retuned from moment to moment, focusing neural activity on what matters most. 🧵1/8 👉 www.science.org/doi/10.1126/...

Adaptive modulation of theta sweeps in the brain’s navigation circuit

Efficient navigation requires prioritizing information from behaviorally relevant locations. In rats, such selective sampling may arise from theta-paced sweeps in grid and place cell populations, whic...

science.org

Now in Science: How does the brain’s navigation system allocate its limited representational resources during behavior? We found that grid cells sweep toward locations of interest, providing a potential mechanism for allocating spatial attention in the cognitive map.🧵 science.org/doi/10.1126/...

Happy to share our preprint! We show that hypothalamic hunger-promoting AgRP neurons reflect proximity to food across different mazes in hungry mice. After mice discover food, AgRP activity decreases as they approach the food and increases as they move away.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2mo ago

Hunger neurons track available food locations during foraging and spatial memory recall https://www.biorxiv.org/content/10.64898/2026.07.28.741066v1

I’m excited to share our latest preprint, and the main work from my PhD, on the role of the direct entorhinal input in hippocampus CA1 spatial coding. 1/9

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo ago

The emergence of a novel CA1 spatial map requires direct entorhinal input https://www.biorxiv.org/content/10.64898/2026.07.02.736055v1

Ever wondered how the hippocampal cognitive map is read-out? @changmin-yu.bsky.social @zilong-ji.bsky.social with Jake & John, show that, during navigation, theta sweeps indicate remembered goal-directions (cf. current/next movements or perceptual targets) 1/2 www.nature.com/articles/s41...

The Moser Group is presenting our work on Wednesday afternoon at #FENS2026! •Mechanism for L-R sweeps •Attention modulation of sweeps •Grid/place remapping rules & dynamics •”Mega torus” as a hi-capacity memory space •Moving the grid bump •Development of tori & rings •RSC/HC pops. in a spatial task

Our work on goal-directed theta sweeps is out! We found two different types of theta sweeps in the rat hippocampus. During random foraging, left-right alternating sweeps dominated (Vollan, 25). However, during memory-guided navigation sweeps pointing to hidden goal locations emerged with learning.

It has been super fun to work on this, where we learned that: 1) Mouse PFC is needed for model-based override of habits. 2) Separate PFC populations encode a 'policy' and the current 'value'. 3) The policy and value codes alternate theta sweeps towards the goal. ...and much much more!

@peterdoohan.bsky.social · 3mo ago

How do brains plan actions towards goals? To get at this question we studied mice navigating complex mazes as goals changed on every trial 🧵 Work with @thomasakam.bsky.social @behrenstimb.bsky.social @kristorpjensen.bsky.social now on BioRxiv: www.biorxiv.org/content/10.6...

Last week, we finally submitted my first paper during my PhD (bioRXiv: www.biorxiv.org/content/10.6...). The paper is about change-of-mind (COM) behavior. You know when you're taking a test and switch your answer after second-guessing yourself? We studied what happens in the brain at that moment.

Story time friends... Ring attractor networks rely on fine-tuned symmetric connectivity. The fly head direction network has ring attractor dynamics but heterogeneous connectivity. How is this possible? 1/🧵 Link: www.biorxiv.org/content/10.6...

Very excited to announce the first preprint from the lab @ucsantabarbara.bsky.social -- "Predictive pursuit emerges in high-dimensional RNNs." @wtredman.bsky.social (starting his own group at JHU this fall) summarizes the work nicely in this thread.

Will Redman@wtredman.bsky.social · 5mo ago

New preprint out 🚨 “Predictive pursuit emerges in high-dimensional recurrent neural networks”! This was an awesome collaboration with co-first author @fatihdinc.bsky.social , @andyalexander.bsky.social, @xiaoxiao-lin.bsky.social, and May Chen biorxiv.org/content/10.6... 1/

My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13

Brilliant work on the development of grid cells by Matteo et al!

Matteo Guardamagna@matteoguardamagna.bsky.social · 6mo ago

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

1/N: Dear cognitive map fans, I’d like to share a model I’ve been working on for a while (clearing backlog :). I show how a vector navigation architecture (VNA) and a “positional inference network” (PIN) can build Universal Cognitive Maps (UCMs) for abstract spaces. www.biorxiv.org/content/10.6...

Fantastic opportunity to do pioneering single-unit recordings from the HUMAN hippocampus and other parts of the brain, with @jorgen-sugar.bsky.social at @uio.no, Norway.

Jørgen Sugar@jorgen-sugar.bsky.social · 7mo ago

We have PhD positions and Post Doc positions available! www.med.uio.no/imb/english/... Please apply if you are interested in human invasive intracranial recordings or applied machine learning in a neuroscientific context. Deadlines 1st of March (Sunday!) and 4th of March. Please RT!

1/6 Do neighboring #PlaceCells in #Hippocampus CA1 map neighboring locations in space? 🧠🗺️ Is there micro-scale spatial topography in the hippocampus? See our latest paper from @kavlintnu now out in @pnas.org www.pnas.org/doi/10.1073/...

Place cells in CA1 lack topographical organization of firing locations | PNAS

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

pnas.org

Edvard I Moser@edvardmoser.bsky.social · 7mo ago

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...

My first first-author paper is on bioRxiv! Here we ask whether the same subset of neurons in ACC always display object correlates during extensive familiarisation to 2 objects. A short 🧵1/10

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 7mo ago

Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex https://www.biorxiv.org/content/10.64898/2026.02.06.704307v1

Happy belated publication of some of my PhD work! Building on our findings that grid field firing rate changes can cause hippocampal remapping and memory impairment, here we show that this effect has a fixed input-output relationship, and we can even predict how place cells will remap!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 7mo ago

Reproducible and predictable reorganization of place fields driven by grid subfield rate changes https://www.biorxiv.org/content/10.64898/2026.02.10.705142v1

We are #hiring 2 PhD students at the University of Oslo! 🇳🇴 1️⃣ Systems Neuro: Spatial memory & addiction 2️⃣ Neuro/Cancer: Glioblastoma invasion. Details: vervaeke-lab.org/Hiring Please RT! 🔄 @UiO_LifeSci #Neuroscience #PhD #SystemsNeuro #Glioblastoma

Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang shuhonghuang.bsky.social with our long-standing collaborator James Fitzgerald at Northwestern.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 8mo ago

Behavioral alignment as an organizing principle in sensory coding https://www.biorxiv.org/content/10.64898/2026.02.04.703828v1

New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP

Check out our commentary on a recent paper arguing that neural activity in the (lateral) entorhinal cortex intrinsically drifts over a month-long period in humans. With @virginievanw.bsky.social @vigano.bsky.social and Raphaël Bordas. www.eneuro.org/content/13/1...

A Passage of Time Signal in the Human Brain

In a dense-sampling resting–state functional magnetic resonance imaging study, Wang et al. (2025) recorded two individuals’ functional connectivity patterns over 30 consecutive days to find a marker o...

eneuro.org

We had a lot of fun doing these experiments! Theta sweeps in MEC and internal direction signals in parasubiculum track moving objects during pursuit and reverse during backward movement. Simultaneously recorded HD cells in other areas remain locked to head direction across behaviors:

Edvard I Moser@edvardmoser.bsky.social · 8mo ago

The hippocampal map has its own attentional control signal! Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉 www.biorxiv.org/content/10.6... 🧵(1/6)

Such an elegant study, congratulations to all of you!

Sachin Sethi@sethisachin.bsky.social · 9mo ago

www.cell.com/cell/fulltex... We had a lot of fun working on this project (led by Itzel Ishida, not on bluesky). Some interesting highlights from the paper -

I’m excited to share my first PhD preprint!🎉 We studied how interactions between medial entorhinal cortex (MEC) and hippocampus shape theta sequences during navigation, and asked whether some “planning-like” patterns in hippocampus could arise from upstream MEC dynamics. (1/8)

1/8 How can the brain create countless unique memories using a single, universal metric of space? We’ve been waiting for the answer to this for two decades! Read it here: www.biorxiv.org/content/10.1...

Functional independence of entorhinal grid cell modules enables remapping in hippocampal place cells

A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few systems where such ...

biorxiv.org

Edvard I Moser@edvardmoser.bsky.social · 12mo ago

1/5 How does the brain turn the low-dimensional, universal grid cell metric into the rich, diverse codes needed for memory in hippocampal place cells? 🧵 Preprint link 👇 www.biorxiv.org/content/10.1...

1/ 🚨 New preprint! 🚨 Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇 📄 www.biorxiv.org/content/10.1... 💻 code + data 🔗 below 🤩 #neuroskyence