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Bahareh Ajami Lab

@baharehajami.bsky.social

Immunologist by heart,#microglia, Immigrant, mom, Triple Negative breast cancer survivor “hopefully”, Opinions mine. #AD, #ALS, #PD

28 Posts232 Follower147 Folgt
Bahareh Ajami Lab@baharehajami.bsky.social · 5mo ago

Excited to share our paper published today in @NatureNeuro: www.nature.com/articles/s41... Using spatial proteomics, we identified a previously undescribed plaque-associated microglial population that emerged only when morphology and spatial context were integrated with protein expression #Microglia

Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states - Nature Neuroscience

Myeloid cells show marked heterogeneity in Alzheimer’s disease. This study introduces CODEX-CNS, a single-cell spatial proteomics pipeline, and identifies a human microglial subpopulation enriched in ...

nature.com

Joe Sabatino@jsabatino37.bsky.social · last yr.

Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid www.nature.com/articles/s41...

Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid - Nature Communications

Cytotoxic T lymphocytes (CTL) have been implicated in anti-PIT-1 hypophysitis, an autoimmune disease, but direct evidence is lacking. Here the authors use induced pluripotent stem cells to generate pi...

nature.com

David Shiffman, Ph.D. 🦈@whysharksmatter.bsky.social · last yr.

Inspired by Vietnam-era activism, Stand Up For Science is hosting a series of teach-ins around the USA this summer, focusing on the importance of science and science funding. I’m doing one May 30th in Silver Spring. Many of you should consider doing one too, and I’m happy to help you plan it 🦑🧪🌎

Flier for the talk
Johnson Lab - University of Iowa@campylobacterlab.bsky.social · last yr.

Hey y'all! My department is conducting a search for an assistant or associate professor in bacteriology. It's pretty broadly defined. If you know anyone who's looking for a great department that does awesome science - please send them our way! You can DM me with any questions you have 😀

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Chrystal Starbird@drstarbird.bsky.social · 2y ago

If only that breast cancer commercial ended with a notice about all the research funding cuts the current administration is pushing through and how it has immediate negative impacts on breast cancer research and screening.

Paul Frankland@franklandlab.bsky.social · 2y ago

Scientist position at The Hospital for Sick Children in Toronto. We are looking for neuroscientists with interests in the molecular and cellular bases of cognition. The position is open-rank, and the successful candidate will also be appointed at U Toronto. Deadline is Feb 15th. Come join us!

career.sickkids.ca

Valerie Tornini@valetornini.bsky.social · 2y ago

We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)! Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!

Open recruitment for the Tornini Lab Department of Integrative Biology and Physiology & Institute for Society and Genetics Hispanic Serving Institution Infrastructure Initiative University of California, Los Angeles (UCLA) www.torninilab.org We are a new developmental, cell, and molecular biology lab interested in understanding the genetics of vertebrate neurodevelopment. We use genome engineering, single-cell technologies, behavioral analyses, pharmacological profiling, confocal imaging, genomics, and computational biology using the vertebrate zebrafish (Danio rerio) system and other models (like sea lamprey) for evolutionary studies. Our work is driven by curiosity, independence and teamwork, fun, a sense of urgency, and a desire to understand how networks of genes regulate brain and organismal development. This work can help us better understand basic mechanisms of what happens in human developmental disorders or diseases and can inform novel therapeutic strategies. We are recruiting across all levels. Our lab works in multiple complementary areas (please see below). We’re looking to match motivated people with what motivates them in a supportive and engaging environment. We are recruiting staff research scientists (1-2 years after undergrad+), graduate students (open rotation positions), postdocs, and other positions as relevant. While multiple of our projects are already funded, we strongly support candidates to identify and apply for your own fellowships/grants with the full mentorship and resources of the lab. Like our research? Think you might be a good fit? Consider joining us! For more information, please visit our website, the next page, or contact Val at: vtornini at ucla dot edu UCLA is an equal opportunity employer. Novel micropeptides in vertebrate neurodevelopment Using zebrafish models, we ask: what are these proteins; what are their functions in neurodevelopment; what are other “ignored” or “dark proteome” genes we are missing; and what can they reveal about human neurodevelopmental disorders or diseases? Chromatin regulators in vertebrate development and behavior A growing group of evolutionarily conserved chromatin regulators have been identified as genes linked with neurodevelopmental disorders, such as autism. In many cases, patients may struggle with co-occurring conditions that impact daily life in childhood and adulthood, including seizures, sleeplessness or sleep disruptions, and autoimmune disruptions. How do these genes work to establish and maintain neural cell types during development, and in turn shape circuits during early critical periods, including interactions with the environment, to establish organismal physiological processes? Non-neuronal regulation during development and aging Non-neuronal cell types, including oligodendrocytes and microglia, have emerged as key players in shaping neurodevelopment and into adulthood. How are the cellular, molecular, and physiological dynamics of these cell types in developing and aging brains affected in mutant genetic models linked to neurodevelopmental disorders? Can we target these cells to modulate neural dysregulation and resulting behaviors in these mutant models? Evolution of vertebrate brain cell states We seek to understand the principles of how novel genes co-evolve with the emergence of neural cell types found only in vertebrates. We use cross-species genomics and functional approaches with the jawless vertebrate model, sea lamprey, to elucidate the roles of vertebrate-specific genes on the gene regulatory networks. Bioethics, neuroethics, and genetics We seek to integrate evidence-based methods throughout our projects to investigate and address bioethical considerations in this research domain.