✍ It's been a journey... Published today in @cp-molcell.bsky.social (www.sciencedirect.com/science/arti...) is the culmination of a lot of work that started over 7 years ago with the observation that the RPA complex could enhance the DUB activity of ZUP1 against K63-linked polyubiquitin chains.

Recent work from the Genome Stability Lab was published in Nature Communications over the summer 👉 www.nature.com/articles/s41... Using systematic screening, photo-crosslinking, high-resolution NMR, and cellular biochemistry, we uncover a UFM1 signalling module in genome stability 🧬

The Genome Stability Lab in @uom-dcs.bsky.social @fbmh-uom.bsky.social is now LEAF Gold!! 🏅 A fantastic team effort to improve the sustainability of our research work into DNA repair and early detection in ovarian cancer 🧪♻️🧬❄️🎨🚲🚌🚂👣 #LEAF #SustainableLabs

Nominations are now open for the 2027 Awards! With 12 categories spanning all career stages, there's never been a better time to recognise the outstanding work of your colleagues. Visit our website to find out how to nominate #BiochemAwards buff.ly/FHTSGz8

This week we held our second Active Travel Brekkie to promote sustainable modes of commuting 👣🚲👟🚌🚋🚂 Inspired by similar events on main campus, it was great to see members of the DCS community enjoying their complimentary breakfast in the Espresso Lab cafe at the OCRB together!

Happy to share our latest work from the Barr lab is now published in @embojournal.org 👉 WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer | EMBO Journal #cellcycle @oxfordbiochemistry.bsky.social www.embopress.org/doi/full/10....

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer | The EMBO Journal

imageimageProlonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest in G1. This work shows how these pathways normally lead to G1 arrest by different routes, and how cancer-a...

embopress.org

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

👇New preprint from the lab of @christineschmidt.bsky.social Using systematic screening, photo-crosslinking, high-resolution NMR, and cellular biochemistry in multiple cell models, we uncover a UFM1 signalling module in genome stability. www.biorxiv.org/content/10.1...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

Interested in developing the skills & knowledge to transform the clinical outcomes for patients with cancer? 🤝Build a global professional network 🌎Study from anywhere in the world 🔬Develop research skills Apply for the Transformative Oncology programme👇 🔗 www.manchester.ac.uk/study/online...

Do you want to be at the forefront of cancer detection & research? 🔬Develop practical skills in cutting-edge research facilities 🌎Work alongside & learn from world-leading researchers & clinical scientists Apply for the Molecular Pathology in Cancer programme 👇 www.manchester.ac.uk/study/master...

Job Alert 🔊🔊 Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy

Register for the @biochemsoc.bsky.social Biochemistry Focus ECR webinar in May where we will hear from a range of speakers showcasing alternative careers in research outside of traditional academic pathways🧫 📅 Thursday 22nd May ⏰ 14:00-15:00 (BST) 📍 Online 🔗 register.gotowebinar.com/register/667...

Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social. www.sciencedirect.com/special-issu...

We @natsmb.nature.com recently published an insightful manuscript on ubiquitin-independent proteasomal degradation via the NUB1-FAT10 axis by the lab of Andreas Martin. A very interesting read found here: www.nature.com/articles/s41...

NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome - Nature Structural & Molecular Biology

Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the human 26S proteasome and use biochemistry, cryo-EM and hydrogen–deuterium exchange to show that NUB1 acts as an ATP-independen...

nature.com

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains

Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

cell.com

Less than 3 weeks left⏳Register by April 7 for the #Ubiquitin & Friends Symposium, May 8-9, in beautiful Vienna! Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/

Later TODAY, we have the next DCS Next-Gen seminar with Dr Peter Martin from The Institute of Cancer Research (ICR) in London 🧬 🧪 Mitotic Genome Stability: The Key to Precision Cancer Therapy? 🔬 📍 Oglesby Cancer Research Building, Lecture Theatre 📅 Monday 17th March ⏰ 3.15-4.15pm

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info

Next Monday, we have the next iteration of our DCS Next-Gen seminar series with Dr Peter Martin from The Institute of Cancer Research (ICR) in London 🧬 🧪 Mitotic Genome Stability: The Key to Precision Cancer Therapy? 🔬 📍 Oglesby Cancer Research Building, Lecture Theatre 📅 Monday 17th March ⏰ 3-4pm

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

TOMORROW, we have the next installment of our DCS Postdoc and PhD seminar series with @benjaminfozzy.bsky.social and Dr Laura Woodhouse! 📍 Oglesby Cancer Research Building, Lecture theatre 📅 Thursday 27th February ⏰ 4-5pm Look forward to hearing about this exciting research!

⭐ DCS Next-Gen Seminar ⭐ Next week, we welcome Dr Marilena Hadjidemetriou from @official-uom.bsky.social! She'll discuss her research on NanoOmics, a Nanotechnology Blood Biomarker Discovery paradigm, which isolates diseased analytes from blood for omics analyses 🩸 📍 OCRB 📅 Mon 24th Feb ⏰ 3-4pm

🧪Later TODAY, we have the next installment of our DCS Next-Gen Seminar Series with Dr William Grey, MRC Career Development Award Fellow from The University of York. 🔬The Grey lab studies the role of proteostasis in healthy and malignant stem cells, predominantly in the haematopoietic system🧬

Today is #WorldCancerDay! 👋 We are officially here on Bluesky 🦋. We are the Division of Cancer Sciences, within @official-uom.bsky.social – representing clinicians, scientists, technicians and students; all working together to demystify cancer. 🔔 Follow us to hear news and updates. #TeamManchester

Since this is back… Unfortunately, academic inflation and toxic productivity culture has all but done away with this. The effects of this on science advancement will be seen for generations. Slowing down and thinking deeply is essential to solve complex problems and it’s undervalued at every level

Studentships available in the lab in the BBSRC NWD scheme (www.bmh.manchester.ac.uk/study/resear...) 2. Using state of the art proximity proteomics approaches to understand ubiquitin-like interactions (with Christine Schmidt and Aaron Trowbridge) #ChemicalBiology #Ubiquitin #CellBiology

#PhD opportunity in GSL @mcrcnews.bsky.social for an exciting project to map interactions for components of ubiquitin-like signalling www.findaphd.com/phds/project... Part of the BBSRC-NWDP, check out other projects, deadlines, and application specifics: www.bmh.manchester.ac.uk/study/resear...