The link to our paper: dlvr.it/TP5gK5

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis

Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...

dlvr.it

Also thanks to Zachary Sebo and Navdeep Chandel for writing a preview to our work as well as a complementary study from Thomas MacVicar's lab www.cell.com/molecular-ce...

An orphan no more: SLC25A45 controls mitochondrial import of methylated amino acids

Solute carrier (SLC) genes encode the largest membrane transporter superfamily, with many orphan members of unknown function. In recent Cell Metabolism and Molecular Cell articles, Khan et al. and Dia...

cell.com

The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.

Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis

Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial impo...

cell.com

AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...

doi.org

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell! We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals! www.sciencedirect.com/science/arti...

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis

Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

sciencedirect.com

Worst week for science EVER. Sunday: ASM scrubs DEI mentions from website. Tue: NASA scrubs DEI from website; ICE arrests a student on campus; NSF plans to cut staff; USAID halted. Wed: HHMI kills diversity program; NIH trashes applications for diversity F grants. Fri: NIH cuts indirects.

This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this? grants.nih.gov/grants/guide...

A Primer on Indirect Cost Rates

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Registration and abstract submissions are open for the Third Annual SoCal Metabolism Symposium at USC. Go to gero.usc.edu/event/third-... The abstract and early bird price deadlines are Feb 28th

Fresh new paper alert 🚨 by @marcellharhai.bsky.social @jourdainlab.bsky.social et al. expanding the inventory of potential #mitodisease genes and a herculean deep-dive into FAM136A across models and human disease! 🧪🧫🐭👂 Really happy to see it out and to have played a small part 🔬 #mito #sciencesky

Alexis A. Jourdain@jourdainlab.bsky.social · 2y ago

New preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by @marcellharhai.bsky.social @fbm-unil.bsky.social A short thread 1/5 www.biorxiv.org/content/10.1...

Really enjoyed writing this spotlight highlighting recent works from @keunwooryu.bsky.social at al in the Thompson lab along with @lyssiotislab.bsky.social and Yatrik Shah! Mitochondria heterogeneity FTW! --- Link below to the spotlight and the original @nature.com articles in the reference👇

Trends in Endocrinology and Metabolism@cp-trendsendomet.bsky.social · 2y ago

ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al. Read it for free until March 19th at: authors.elsevier.com/a/1kWLq3jDgW...

ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al. Read it for free until March 19th at: authors.elsevier.com/a/1kWLq3jDgW...

I got home from lab and immediately called and wrote to my representative and senators. I urge you to do the same.

The Washington Post@washingtonpost.com · 2y ago

Breaking news: The White House budget office is ordering a pause to all grants and loans disbursed by the federal government, according to an internal memo sent to agencies Monday, creating significant confusion across Washington.

I decided to be more efficient in my doomscrolling & made my first starter-pack!😅 These are folks that IMO have been great sources of reliable info during the federal communication ban. Please 1) tell me if you want to be taken off, and 2) give suggestions for others to add go.bsky.app/KZnq7Qe

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

White House pauses all federal grants, sparking confusion

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

washingtonpost.com

All NIH/NSF awards may be paused as of today. Money is disbursed annually, so if you have your money, you're OK for a while. My next R35 grant year starts Apr 1. I hope Trump doesn't read my X/bsky feeds that say he's a racist, a rapist, a cheat, & a traitor. www.washingtonpost.com/business/202...

White House pauses all federal grants, sparking confusion

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

washingtonpost.com

From a source inside the National Cancer Institute: “Everyone is scrambling to figure out how we’re supposed to work to serve the public when we can’t engage at all.”

Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately. There will be a training over zoom at the beginning of the event. Join us! form.jotform.com/250226137228...

Join researchers across the country in fighting restrictions on the NIH

Please click the link to complete this form.

form.jotform.com

Reiterating my call to fellow federally-funded scientists: Call your reps, tell them how this hurts science and everything good that comes from science (Also non-scientists, and scientists without federal funding! But the more of us who can directly speak to the impacts of these freezes the better)

Jonathan Lambert@jonlambert.bsky.social · 2y ago

The National Science Foundation cancelled over 60 grant review panels today, effectively grinding funding of new projects to a halt. The so-far indefinite pause comes as NSF grapples with the impact Trump's executive orders will have on their grantmaking process. www.npr.org/sections/sho...

I'm one of these 11,965, and with funding from the NIH and NSF, I've been able to recruit several more full-time employees to MI (many coming from other states!) since 2023. @repdingell.bsky.social, please advocate for us in science, health, and research to continue supporting the michigan economy

@habu333.bsky.social · 2y ago

I looked up Michigan NIH numbers.

Crazy that I defended on Friday! Really appreciate everything I learned from Yatrik and @lyssiotislab.bsky.social over the years! Can't ask for better mentors, labs, colleagues, friends, and support over the years! Next step, postdoc with Kivanc Birsoy at Rockefeller University !🧿🗽

The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!

hahahahahahaha

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n