I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

What happens if you delete large intronic regions? In human tissue culture cells, we found many deletions that decrease growth and some that increase it. In most cases, deletion affected expression or splicing of the gene. www.cell.com/cell-reports... 1/3

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns

Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...

cell.com

Luke LeBrun@lukelebrun.ca · 3w ago

These photos of FNs community members fleeing their homes by boat are genuinely apocalyptic (Photo via Wayne Wastaken of Collins, Ontario, who says his “hometown is gone”) www.facebook.com/share/r/1ArN...

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6...

Introduce yourself with 10 bands you've seen live: Garbage The Cure Chumbawamba The Prodigy Arctic Monkeys White Lies In the Valley Below Massive Attack IAMX Austra

Ollie Rando@epididymosome.bsky.social · 3mo ago

Introduce yourself with 10 bands you've seen live: Grateful Dead Tool Parliament Dresden Dolls Cypress Hill Rasputina Kool Keith/Dr Octagon/etc Phish Rage Against the Machine Prince

Are you a #Masters student interested in translational #cancer research, tumor immunology and #CRISPR screens? Then apply to our lab at the @impvienna.bsky.social in Vienna: www.imp.ac.at/career/open-... #oncology, #cancerresearch, #CRISPR

Today in AI: Canada rejected the PR application of a McMaster postdoc from the Sorbonne who works in the immunology of aging because the generative AI being used to process applications (😱) entirely hallucinated her credentials. Everyone involved should be fired. archive.is/ELrCI#select...

Alu repeats have played important roles in the evolution of (alternative) splicing via exonization and in other ways. In this paper, we show that they mediate interactions across exons to loop them out. Alus inserted this way in evolution render exons alternative. bit.ly/4t8Yahh 1/2

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes - Genome Biology

Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-de...

bit.ly

📣 Call for Applications: The University of Vienna invites applications for more than 40 fully funded doctoral positions across a broad range of disciplines in Life Sciences and Natural Sciences. 👨‍🔬👩‍🔬 #PhDSky #PhD #univie 📅 Application period: 2 March – 27 March 2026, 12:00 CET More information: ⤵️

🚨🧬🚨 We're looking for a specialized Research Assistant to spearhead a project aimed at exploring new RNA therapeutics in diabetes and other metabolic disorders. Junior or Senior, we're hoping to recruit a highly motivated and self-driven scientist interested in both basic and applied science. 🦄

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

Join the Vienna BioCenter Scientific Training as a Coordinator and play a key role in supporting the full administrative journey of PhD students! 🙌 If you are organized, enjoy independent work, and thrive in a dynamic setting, apply now ➡️ tinyurl.com/5sc2a37s

AI agent goes nuts on open source maintainer after having its pull request denied. This is a pretty insane story. Open source development as we've been used to for the last few decades is likely over. 1/ theshamblog.com/an-ai-agent-...

An AI Agent Published a Hit Piece on Me

Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…

theshamblog.com

A French judge explains how Trump sent people from the US Embassy to try to intimidate her during Marine Le Pen's trial for embezzlement — something they've done to other judges around the world

Dear Americans: When you say "The Republicans won't stop Trump and there's nothing we can do", please understand that the rest of us hear "Sorry you may have to fight WW3 against us but it is what it is".

Job alert! Assistant professor position in the Department of Molecular Genetics (University of Toronto). Amazing department and city. jobs.utoronto.ca/job/Toronto-... Please share.

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004

The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

nature.com

1/ @reviewcommons.org, @embo.org's preprint peer review platform, is taking an important step forward. Multiple publishers, including eLife, are now jointly running the peer-review process on behalf of the platform. 🔗 buff.ly/Rm1XotK

Our fully-funded PhD program is open for applications! Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity. Apply now: phd.ista.ac.at

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

Have you recently completed (or finishing soon) a PhD in CS or a related discipline? Do you want to do research advancing the theory & practice of algorithmic genomics & build tools that people love to use? I'll be looking to hire a postdoc! Official ad coming soon: docs.google.com/document/d/1...

Postdoc Description.docx

Title: Postdoctoral Associate Summary statement: The postdoctoral research associate is responsible for developing novel computational methodology for high-throughput sequence genomics tasks, as well ...

docs.google.com

Our PhD program offers many training activities and courses for your future career. Check out the range of fully-funded PhD positions in our Autumn call before 10 October 2025: www.vbcphd.at

Researchers have discovered a new biological process they've called 'interstasis', which keeps groups of proteins in check, preventing excessive build up and protecting the cell from potential harm. www.crick.ac.uk/news/2025-09...

Better together: researchers discover how cells keep groups of proteins in check

Researchers have discovered a new biological process that they’ve called ‘interstasis’, a way for cells to promote the equilibrium of functionally-related proteins, preventing too many from accumulati...

crick.ac.uk

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

Hello World! So much going on in the field and much to discover. Lucky to have participated and witnessed all this enlightening science at #ESEB2025. Interested in a postdoc uncovering novel evolutionary conflicts involving chromatin? Please reach out, we are hiring. #MolaroLab #watwat @igred.fr

Antoine Molaro@antoinemolaro.bsky.social · last yr.

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇 tinyurl.com/PostdocEvoEp... Repost are appreciated

A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing. www.uu.se/en/about-uu/...

Postdoctoral position - Uppsala University

Postdoctoral position, Department of Immunology, Genetics and Pathology, Uppsala University

uu.se