Christian Brueffer

@brueffer.io

Consultant in #bioinformatics and #cancer applications @insilico.consulting (all things #genomics, #liquidbiopsy, and #workflows) • 🇸🇪 🇩🇪 • 🧬🖥️ • https://brueffer.io ORCiD: 0000-0002-3826-0989

Fantastic to see this work published, congratulations to all co-authors! It further validates the value of structural variants (SVs) as biomarkers for cancer liquid biopsy, as implemented in SAGA Diagnostics' Pathlight MRD test. #ctDNA #MRD #LiquidBiopsy #PrecisionMedicine #BrCa #BreastCancer

EMBO Molecular Medicine@embomolmed.org · 2mo ago

NeoCircle: pre- and post-operative #ctDNA dynamics predicts survival in neoadjuvant-treated early #BreastCancer By A. George, @laosaal.bsky.social & colleagues at @lund-university.bsky.social 🗞️ doi.org/10.1038/s44321-026-00447-z Press release: www.lunduniversity.lu.se/article/bloo...

Hiring Senior Computational Postdoc to lead large-scale scRNAseq analysis for Project JAGUAR, one of the world’s most comprehensive single-cell immune resources from Latin American ancestries. If big data, global partnerships, human diversity and immune regulation excite you, apply! bit.ly/3XyFWrW

Senior Postdoctoral Fellow

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

sanger.wd103.myworkdayjobs.com

Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

jobs.icr.ac.uk

Opportunity! Anybody knows of young marine ecologists (within 7 years from earned PhD) that would like to come to Gothenburg, Sweden, for a nationally funded Assistant Professorship? It is highly competitive but well funded. (1) of (3)

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

🚀 Truvari v5.0 is here! 🎉 What’s new? 🔹 Enhanced symbolic variant support for <DEL>, <DUP>, <INV> 🔹 Robust BND comparison for cross-representation SV matching 🔹 Improved SV sequence similarity & HUGE SV support 🔹 Cleaner UI & Revamped API 👉 More: github.com/ACEnglish/tr... #Genomics #Bioinformatics

GitHub - ACEnglish/truvari: Structural variant toolkit for VCFs

Structural variant toolkit for VCFs. Contribute to ACEnglish/truvari development by creating an account on GitHub.

github.com

#ICYMI our deep dive into ALK1 biology, at the intersection between angiogenesis and immunology with clear implication for the targeting of immunomodulatory cues & cancer therapy!

Journal of Clinical Investigation@jci.org · last yr.

Targeting the most immune-suppressive macrophage with ALK1 inhibitors in malignant breast cancer! @kpietraslab.bsky.social & team @lund-university.bsky.social target the most immune-suppressive macrophage with ALK1 inhibitors in malignant breast cancer models! buff.ly/FXssb1x

BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...

Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers

Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...

aacrjournals.org

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Our first curated draft somatic structural variant benchmark for the new GIAB PDAC tumor cell line HG008-T is at ftp-trace.ncbi.nlm.nih.gov/ReferenceSam..., based on extensive short+long read sequencing data described in doi.org/10.1101/2024.... Feedback to improve future versions is very welcome!

Index of /ReferenceSamples/giab/data_somatic/HG008/Liss_lab/analysis/NIST_HG008-T_somatic-stvar_DraftBenchmark_V0.1-20241219

ftp-trace.ncbi.nlm.nih.gov

Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc

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