Excited to share that I received this year's Antoni van Leeuwenhoek (AVL) award for my PhD research 🧬 A big thank you to my PhD mentor @josjonkers.bsky.social and everyone else who has contributed to this work at @nkinl.bsky.social 🌟 www.nki.nl/news-events/...

🐭 In vivo veritas 🐭 Now out in Nature Genetics: @josjonkers.bsky.social and I describe currently available mouse models of BRCA1/2 and their roles in understanding BRCA1/2 biology, particularly in normal development, tumor suppression and therapy response. www.nature.com/articles/s41...

Insights from three decades of BRCA1/2 modeling in mice - Nature Genetics

This Perspective highlights the insights into the biology of BRCA1/2 afforded by mouse models and patient-derived tumor xenografts and emphasizes their value in addressing unresolved questions and pre...

nature.com

One week to go until my PhD defense ⏳🎓 To mark this occasion, @unileiden.bsky.social kindly featured my research in their most recent article - check it out below 🧬👩‍🔬

Unlocking the secrets of DNA repair: Sarah’s curiosity might lead to new cancer treatments

How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could he...

universiteitleiden.nl

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Repair of DNA double-strand breaks leaves heritable impairment to genome function

Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...

tinyurl.com

What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity? Enhanced DNA repair www.nature.com/articles/s41... erictopol.substack.com/p/a-long-awa...

Evidence for improved DNA repair in long-lived bowhead whale - Nature

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

nature.com

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Vijay Ramani@vram142.bsky.social · 11mo ago

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Histone Recycling Promotes PARP Inhibitor Resistance

Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...

aacrjournals.org

Big congratulations to @sarahmoser.bsky.social @oncodeinstitute.bsky.social for being named a 2025 International Birnstiel Award laureate! Selected from 87 nominations, Sarah is one of just six doctoral researchers worldwide to receive this prestigious recognition in molecular life sciences.

Honoured (and excited!) I was named among this year's Birnstiel awardees for my PhD work! 🎉

IMP@impvienna.bsky.social · 11mo ago

Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance go.nature.com/45vRWhd

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

go.nature.com

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

nature.com

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

nature.com

🗓️ @mylliabio.bsky.social sponsors the first conference on "High-Content CRISPR Screening" from March 18-19, 2026 in Vienna: perturb2026.bio Scientific topics: 🔬 CRISPR-based screening strategies 🧬 Perturb-Seq & CROP-Seq 💻 Computational analyses 💻 AI models of human cells 📸 Image-based screens

New online! Making sense of the polygenicity of complex traits

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

science.org

🚨Roadmap 🚨 Alice Soragni @alice.soragnilab.com‬, Erik S. Knudsen ‪@roswellpark.bsky.social‬ ‪ & Co discuss the mechanisms of acquired resistance and the models to better study it to advance predictive and proactive prevention in cancer therapy. 📖 ⬇️

Acquired resistance in cancer: towards targeted therapeutic strategies - Nature Reviews Cancer

Acquired therapeutic resistance is a key contributor to cancer treatment failure, requiring new approaches to address its complex mechanisms. In this Roadmap, Soragni, Knudsen and colleagues discuss the mechanisms of acquired resistance and the models to better study it. Finally, they promote integration of biomarker-driven strategies and cutting-edge technologies to advance predictive and proactive prevention in cancer therapy.

bit.ly

Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research. With @oncodeinstitute.bsky.social #AlpedHuZes #cancerresearch #ad6 #NKI

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology. www.nature.com/articles/s41...

In a remarkable new paper researchers take a very unconventional approach, introducing into yeast cells (S. cerevisiae) entirely new chromosomes whose DNA never existed in a eukaryotic nucleus. They do this by making the entire bacterial genome of two different bacteria into a yeast chromosome 3/n

Paired-Damage-seq is an in situ labeling-by-repair strategy for joint profiling of oxidative and ssDNA damage alongside gene expression, in single cells. www.nature.com/articles/s41...

Our new findings on how chromosomes get ready for cell division are now published in @cellpress.bsky.social! Congratulations, Kai, @andibrunner.bsky.social and everyone else involved! 🤩 www.sciencedirect.com/science/arti...

Nanoscale DNA tracing reveals the self-organization mechanism of mitotic chromosomes

How genomic DNA is folded during cell division to form the characteristic rod-shaped mitotic chromosomes essential for faithful genome inheritance is …

sciencedirect.com

EMBL@embl.org · last yr.

Did you know that DNA must form overlapping loops to give rise to the well-known X-shape of chromosomes? 🧬🧪 New research from EMBL's Ellenberg Group provides new insights into the process of chromosome formation. @ellenberglab.bsky.social @andibrunner.bsky.social www.embl.org/news/science...

📢The programme for #DDRCT25 is now available! Visit our website to explore the exciting sessions, speakers, and key topics we have in store. ➡️Check it out here: fusion-conferences.com/conference/177

BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...

🥳 First up in #NRCtop10of2024: Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang https://bit.ly/4hE1x... #cancerimaging #cancerscreening #cancerprevention @natureportfolio.bsky.social #NRCtop10of2024

Emerging strategies to investigate the biology of early cancer - Nature Reviews Cancer

Understanding the early steps of cancer development is crucial for cancer prevention. In this Review, the authors summarize the advantages and limitations of clinical samples, autochthonous mouse models and organoid models, alongside advanced techniques such as direct imaging, lineage tracing...

bit.ly

30 years after the discovery of the BRCA1/2 genes, Khalizieva et al. provide a historical account of the key discoveries in BRCA1/2 genetics that contributed to our understanding of their function in DNA repair and cancer. Learn more here: ➡️ tinyurl.com/gd352083

“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽‍🔬

Who’s quitting academia? Data reveal gender gaps in surprising fields

Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

nature.com

Happy to have contributed to this issue 🎉 @akhalizieva.bsky.social did an amazing job exploring our current knowledge on our two favourite genes, BRCA1 and BRCA2, and how this is being used to target BRCA1/2-mutated tumors. Check it out ⬇️ genesdev.cshlp.org/content/39/1...

Genes & Development@genesdev.bsky.social · 2y ago

NEW ISSUE !!! Leading scientists come together to discuss recent advances in cancer biology in this collection of comprehensive Reviews spanning different cancer types and various aspects of cancer biology. Learn more here: ➡️ genesdev.cshlp.org/content/curr...

Great perspective on the importance of conventional chemotherapy. Despite many many decades of successful use, do we understand how these drugs work? www.nature.com/articles/s41...