Cadwell Lab

@cadwelllab.bsky.social

We investigate the interface between the immune system and diverse infectious agents ranging from friendly gut microbes and viruses to disease-causing parasites Our Lab: https://www.med.upenn.edu/cadwell-lab/

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

For those still interested in infection and the brain - here is a nice mix of math and pathogens - that tests the function of latency and how the immune system deals with a neuronal infection. Lots going on here to dissect - but turns out latency benefits host and parasite. rdcu.be/efknc

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii

Nature Microbiology - In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.

rdcu.be

@cadwelllab.bsky.social has already posted about it, but we do have a new paper out about rewilding the immune system! This one is led by Ying-Han Chen (then NYU, now Academia Sinica) and Kimberly Zaldana (NYU), and it dives into the world of B cells. www.science.org/doi/full/10....

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

science.org

Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!

Journal of Experimental Medicine@jem.org · last yr.

First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/... #InfectiousDisease

Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/... Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n

Rewilding catalyzes maturation of the humoral immune system

Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.

science.org

Fundamental research led to the discovery of #Remicade, the first biologic drug that has saved millions of people from suffering. The Vilceks have channeled their fortunes into supporting #immigrants. Please check out various opps on the website!

The Vilcek Foundation@vilcekfoundation.bsky.social · 2y ago

⭐️ Hello, @bsky.app! For those of us who don't know us: The Vilcek Foundation was founded by Jan and Marica Vilcek in the year 2000 to raise awareness of immigrant contributions in the U.S., and to foster appreciation for the arts and sciences. #Nonprofit #Philanthropy #Immigrants #Arts #NYC