1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!

New paper out in Neuro-Oncology Pediatrics. Thanks to everyone who worked on this with me.

Alexander Pietras Lab@pietraslab.bsky.social · 3w ago

@elinnjohansson.bsky.social's latest paper is now online in Neuro-Oncology Pediatrics: ACVR1 mutations are shared by DMG and the bone disorder FOP, where hypoxia drives disease. Turns out hypoxia signaling is up in ACVR1-mutant pediatric gliomas too. Open access here: doi.org/10.1093/neup...

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Out now in Science: Two papers from our lab reveal VIPR, an RNA-guided DNA-targeting system in bacteriophages, providing clues to the origins of CRISPR www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... Congrats to Peter Yoon, @kenjmloi.bsky.social @terryzzy.bsky.social, T.Docter & team

A noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-Cas

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

science.org

"A Russian missile wiped out an entire family. Will this photograph stop the war? Most likely not. But I believe the world needs to see the truth," said photographer Yefrem Lukatsky. "I hope those whom this photograph will hurt can forgive me. Kyiv, July 6, 2026," he added.

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Feeling like learning about a secret astrocyte network in the brain? Check out the latest from @melcooperphd.bsky.social in @nature.com. www.nature.com/articles/s41... (take two because I'm out of action on the socials!)

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪 To learn about ➡️ Dynamics of immunological tissue architecture in the human gut ⬅️ by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social REGISTER NOW! www.trippus.net/summerschool...

Summer School 2026

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

trippus.net

Claudio Cantù@claudiocantu81.bsky.social · 7mo ago

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS To learn Enhancer dynamics in living Drosophila embryos by ⭐ prof Takashi Fukaya⭐ @fukayalab.bsky.social @utokyoofficial.bsky.social @kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social REGISTER www.trippus.net/summerschool...

🚨🚨🚨Job alert We are looking for postdoc joining our lab. If you are interested in subcellular distribution of proteins using iPSC and animal models in combination with leading genome engineering tools, check this add out!! 🧠🧬🔬🧫💊 www.linkedin.com/posts/karl-c...

Postdoctoral position (scholarship) in metabolic-epigenetic interplay | Karl Carlström

📣 📣 📣 Job alert!!! Join us at Karolinska Institutet We are looking for a postdoc to the Carlström lab curious to dissect metabolic and epigenetic interplay using iPSCs and animal models coupled with...

linkedin.com

KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...

New map reveals how adult brain cells remember their origins

Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...

news.ki.se

Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 7mo ago

Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...

Latest form GCB lab!! Great work Muk!!🎉🎉🎉

Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 7mo ago

Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs! www.nature.com/articles/s41...

A study published in @nature.com today presents a new method that makes it possible to generate CAR-T cells inside the body. Several types of #cancer were treated in mice without the immune cells needing to be extracted and processed in a laboratory 🧪 #immunotherapy news.ki.se/immune-cells...

Let me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...

Check our latest preprint, Christoffer et al. at our lab developed KaroSpace, with which you can quickly generate a browser to explore your own or published spatial omics data! And here goes my soundtrack to spatial explorations, DJ-Kicks by Erlend Øye youtu.be/naKrdCozPUg?...

chrismlangseth.bsky.social@chrismlangseth.bsky.social · 7mo ago

Let me introduce you to KaroSpace, which is a rapid-access framework for interactive exploration of multi-sample spatial omics data. The preprint can be accessed here: www.biorxiv.org/content/10.6...

We are hiring! Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se. If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out! #hiring #sciencejob #STEMJobs

Congrats @patrikernfors.bsky.social!!! Our head of the MolNeuro unit at @ki.se, an inspiration to all of us!

The Brain Prize@brainprize.org · 7mo ago

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026

KI researchers have identified the neurogenic progenitor that gives rise to dopaminergic neurons – the primary neurons affected in #Parkinsons disease and essential for controlling movement. The study is published in @natneuro.nature.com 🧪 #neuroscience news.ki.se/how-dopamine...

How dopamine producing neurons arise in the developing brain

In a new study from Karolinska Institutet, published in Nature Neuroscience, researchers have identified the neurogenic progenitor that give rise to dopaminergic neurons, the primary neurons affected ...

news.ki.se

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis: @cellpress.bsky.social www.cell.com/cell/fulltex...

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

Microglia checkpoints promote healthy myelin aging Our new paper is out in Nature Neuroscience @natneuro.nature.com www.nature.com/articles/s41... 🧵1/3

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

nature.com

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.

First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS

Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...

rdcu.be

Margherita Zamboni@margheritazamboni.bsky.social · 10mo ago

Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome. 🔗 biorxiv.org/content/10.1... A short thread (by Juliane Weller)👇

Generating long deletions across the genome with pooled paired prime editing screens

Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

biorxiv.org

A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...

Oligodendrocytes show early changes in multiple sclerosis

A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...

news.ki.se

Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com! Check it out at: www.nature.com/articles/s41... with @pkukanja.bsky.social, @deckardw.bsky.social, among others

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience

Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...

nature.com

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Susi Bantele@sbantele.bsky.social · 11mo ago

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

Scientists map how the brain develops – and how it resolves inflammation

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

news.ki.se

Gonçalo Castelo-Branco@gocastelobranco.bsky.social · 11mo ago

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience @gocastelobranco.bsky.social news.ki.se/scientists-m...

Scientists map how the brain develops – and how it resolves inflammation

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

news.ki.se