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Cesar Valades-Cruz

@cessvala.bsky.social

BioImage Analyst • Associate Researcher at Institute of Hydrobiology, Chinese Academy of Sciences https://cessvala.github.io/

11 Posts47 Follower98 Folgt
Cesar Valades-Cruz@cessvala.bsky.social · 3mo ago

Happy to share 4polar3D #SMOLM @natcomms.nature.com! Great collab with S. Brasselet, @charitra.bsky.social,M. Sison, @agvesga.bsky.social,J. Rey-Barroso,V. Curcio,L. Alemán-Castañeda,M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis @institutfresnel.bsky.social @france-bioimaging.bsky.social CAS

4polar3D single molecule imaging of 3D orientation in dense actin networks using ratiometric polarization splitting - Nature Communications

This article presents a method capable of imaging the 3D orientation and lateral positions of fluorescent single-molecule labels in cells. It is applied to the 3D organization of actin filaments withi...

nature.com

Cesar Valades-Cruz@cessvala.bsky.social · 4mo ago

Amazing work from our lab at the Institute of Hydrobiology, CAS! 🎉 Congrats to Q. Sun and all coauthors! 👏 Work led by Prof. Zhang Cheng-Cai and Dr. Zeng Xiaoli 🔬 @plosbiology.org #cyanobacteria #microbiology

PLOS Biology@plosbiology.org · 4mo ago

Cyclic‑di‑GMP regulates diverse #bacterial functions, but what #enzymes coordinate its homeostasis? This study shows that the 16 enzymes involved in #c-di-GMP turnover in #Anabaena function as an electromechanical-like dual relay to control #CellSize & viability @plosbiology.org 🧪 plos.io/3QubUVG

Top: Micrographs of Anabaena filaments of WT, ΔcdgSpICT-all1219 strains (left), and Δ8DGC-1 strain (right) cultured in BG11 medium with (+) or without (−) Cu2+ and theophylline at the indicated time points. Scale bars represent 15 µm. Bottom: Schematic of the proposed dual-threshold c-di-GMP regulatory system that governs cell growth and survival in Anabaena.
Cesar Valades-Cruz@cessvala.bsky.social · 5mo ago

A nice perspective article led by Prof. Cheng-Cai Zhang, Prof. Wei Miao & Prof. Kaiyao Huang from IHB, CAS, on the shift from “gene editing” to “cell editing.” 🧬 Published in The Innovation Life, it highlights how synthetic biology may move beyond DNA editing toward engineering cellular systems. 🔬📖

The Innovation@theinnovation.bsky.social · 5mo ago

Deng et al. propose cell editing—a technology inspired by endosymbiosis—for implementing complex functions into a host chassis that are currently difficult or impossible to achieve. doi.org/10.59717/j.x... #LifeSciences #syntheticbiology #cellediting #biotechnology

Cesar Valades-Cruz@cessvala.bsky.social · 10mo ago

Very interesting paper from our lab (Zhang Cheng-Cai’s group at IHB-CAS)! Functional dissection of the CRP-family transcription factor DevH and its interplay with NtcA in a cyanobacterium. Published in Cell Reports (@cp-cellreports.bsky.social) www.cell.com/cell-reports...

Functional dissection of the CRP-family transcription factor DevH and its interplay with NtcA in a cyanobacterium

Xu et al. uncovered how duplicated transcription factors DevH and NtcA achieve functional specialization in Anabaena. Unlike NtcA, DevH operates at higher cellular levels with broader regulatory capac...

cell.com

Cesar Valades-Cruz@cessvala.bsky.social · 11mo ago

Great review by S. Brasselet & M.D. Lew in @natphoton.nature.com on single-molecule orientation & localization microscopy ( #SMOLM ). These methods resolve both the 3D position of single molecules and their orientation/wobble. @institutfresnel.bsky.social @lewlab.com www.nature.com/articles/s41...

Single-molecule orientation and localization microscopy - Nature Photonics

The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.

nature.com

Cesar Valades-Cruz@cessvala.bsky.social · last yr.

Happy to share our work on polarized super-res imaging: 4polar3D in bioRxiv! Great collab with S. Brasselet, @charitra.bsky.social , M. Sison, @agvesga.bsky.social , J. Rey-Barroso, V. Curcio, L. Alemán-Castañeda, M. Alonso, @renaudpoincloux.bsky.social & M. Mavrakis www.biorxiv.org/content/10.1...

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bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

4polar3D : Single molecule 3D orientation imaging of dense actin networks using ratiometric polarization splitting https://www.biorxiv.org/content/10.1101/2025.07.13.664601v1

France-BioImaging@france-bioimaging.bsky.social · last yr.

Congratulations, Cesar, on your publication! 👏 Discover Cesar’s research on Lattice Light Sheet imaging and image analysis, conducted in collaboration with Ludger Johannes’ team at Institut Curie ⤵️

Cesar Valades-Cruz@cessvala.bsky.social · last yr.

Happy to contribute to the analysis of β1integrin endocytosis using @the.3i.social LLSM, now in @naturecellbiology.bsky.social rdcu.be/eaLM9 L. Leconte @christianwunder.bsky.social @aforrester.bsky.social @ewanmacdonald.bsky.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social

Alison Forrester@aforrester.bsky.social · last yr.

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

Christian Wunder @ Curie Institute@christianwunder.bsky.social · last yr.

Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis. => A proton pump driven glycoswitch @naturecellbiology.bsky.social : rdcu.be/eaLM9 #glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer

"Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis" An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.
Cesar Valades-Cruz@cessvala.bsky.social · last yr.

Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis - Nature Cell Biology

MacDonald et al. show that EGF triggers de-sialylation of plasma membrane glycoproteins like integrins in a mechanism that depends on the Na+/H+ antiporter NHE1 and the neuraminidases Neu1 and Neu3. I...

nature.com

Ewan MacDonald@ewanmacdonald.bsky.social · last yr.

Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….