Heterogeneity of late #endosome/#lysosomes shown by multiplexed DNA-PAINT imaging. Quantitative pipeline developed by Charles Bond, Melike Lakadamyali @melikel.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
New research from the Lamaze team 🎉 mechanical stress triggers caveolae disassembly, releasing caveolin-1 scaffolds that diffuse across the plasma membrane to remotely inhibit key signalling enzymes. www.nature.com/articles/s41... @natcellbio.nature.com #CellBiology, #CellBio, #microscopy
My choice last week in @science.org Deltaviruses spread through a viral Trojan Horse 10.1016/j.cell.2026.01.037
As a historic world record has just been broken at the London marathon 🏃♂️, CNRS researchers explain why runners often experience a sharp drop in performance, called the "30-km wall", at the 30th kilometre, and how to counter this phenomenon.
Breaking the wall
news.cnrs.fr
📢 Seminar – Thurs, June 26, 11am @cnrsoccitanieest.bsky.social 🧪 Dr. Itay Budin (UC San Diego) will talk about how small lipid changes shape membranes & help marine life adapt to pressure/temp — with insights into climate resilience 🌊❄️🔥 📰 2023 Science paper: pubmed.ncbi.nlm.nih.gov/38935710/
Nice interview with @franbottanelli.bsky.social in @jcellsci.bsky.social. Academics in Berlin, what are you waiting for? Fran wants to form a band! journals.biologists.com/jcs/article/...
Cell scientist to watch – Francesca Bottanelli
ABSTRACT. Francesca Bottanelli is an Assistant Professor in the Department of Biochemistry at Freie Universität Berlin (Germany). Francesca graduated in Plant Biotechnology from the University of Mila...
journals.biologists.com
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
🚨 New review out! We explore how extracellular acidification shapes key processes like endocytosis, neurotransmission & immune responses — and highlight tools to study it. 📖 Read more [https://doi.org/10.1016/j.ceb.2025.102531] w/ amazing collaborators 🙌 #CellBiology #Endocytosis #GPCR
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Do not miss the #membrane seminars this THU! As usual zoom link and info here felixcampelo.wixsite.com/membranetraf... or via the mailing list lists.icfo.es/mailman/list... @felixmendu.bsky.social @ishier.bsky.social
JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases www.jci.org/articles/vie...
JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases
jci.org
... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate
Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...
biorxiv.org
Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis. => A proton pump driven glycoswitch @naturecellbiology.bsky.social : rdcu.be/eaLM9 #glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer
Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….
nature.com
Happy to contribute to the analysis of β1integrin endocytosis using @the.3i.social LLSM, now in @naturecellbiology.bsky.social rdcu.be/eaLM9 L. Leconte @christianwunder.bsky.social @aforrester.bsky.social @ewanmacdonald.bsky.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social
Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime www.nature.com/articles/s41...
Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
nature.com
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...
I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies. doi.org/10.1111/boc....
Flotillins in membrane trafficking and physiopathology
Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...
doi.org
