Pls Repost! I've set up a central resource of post doc opportunities for BME and related areas: 📌 For PIs & Lab Leaders: Submit your open postdoc positions here: go.unc.edu/BME-PD-Form 🔎 For Trainees & Job Seekers, browse current postdoc opportunities: go.unc.edu/BME-PD-Posti...

New facets of eicosanoid signaling in TB: crosstalk with a specialized population of granuloma-associated fibroblasts. Happy to share new work led by Erika Hughes, with @charliejpyle.bsky.social and many other wonderful collaborators not on BlueSky.

Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial containment

Hughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in ...

cell.com

The Rawls Lab is hiring! We are seeking a motivated research technician to support cutting-edge studies in gastrointestinal physiology using zebrafish & mice. To learn more about this hands-on & in-person position at Duke University in Durham NC, click here: careers.duke.edu/job/Durham-R...

On August 1, 1931, Harriet Creighton and Barbara McClintock published the first experimental proof that genes are physically located on chromosomes—a discovery that transformed genetics. 1/3🧵

The ZDM19 meeting in Oxford is coming up soon! We have a great list of speakers, lots of early career researcher events, and an amazing location. Registration is open now but early bird pricing will end soon - so please register as soon as possible! www.zdmsociety.org/zdm19-regist...

What would happen if Darwin, Russell Wallace and Koch walked into a bar? We present our new way to study mycobacteria, employing a macroevolution framework (species not strains). Possibilities are endless!! Thanks to Fernanda Subtil for pushing this. elifesciences.org/articles/101...

A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms

Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.

elifesciences.org

Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...

Cool new granuloma findings we just published in JCF in collaboration with Ravi Karra’s Lab, here at Duke. Tilmanocept, a cancer diagnostic, can be repurposed to identify cardiac sarcoidosis granulomas, which could be a noninvasive alternative to diagnostic biopsy! onlinejcf.com/article/S107...

Tilmanocept Labels Granulomas in Cardiac Sarcoidosis

Sarcoidosis is a systemic, inflammatory disease defined by the presence of noncaseating granulomas in affected organs. Single-cell and spatial profiling have resolved granulomas to be highly ordered s...

onlinejcf.com

Antigen-stabilizable fluorescent nanobodies that become fluorescent upon binding intracellular targets enable background-free multicolor imaging and biosensing in living systems. @sdeoliveira.bsky.social www.nature.com/articles/s41...

Synthetic multicolor antigen-stabilizable nanobody platform for intersectional labeling and functional imaging - Nature Methods

A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living syst...

nature.com

An interesting new study, by Clare Smith’s lab and me, here at Duke. We found that during Mtb infection, CCR6 knockout mice (on a B6 background) form necrotic pulmonary granulomas, have increased IL17 production and have sex specific differences in susceptibility. journals.asm.org/doi/10.1128/...

CCR6 is essential for effective immunity against Mycobacterium tuberculosis infection in mice | Infection and Immunity

An estimated 10.8 million people worldwide were infected with tuberculosis (TB) in 2023, and among those cases, 1.25 million people succumbed to disease (1); 90% of people who become infected with Myc...

journals.asm.org

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1

#OTD in 1964, Yvonne Barr co-discovered the Epstein-Barr virus, the first known 𝘩𝘶𝘮𝘢𝘯 tumor virus. She cultured the cell lines that allowed the virus be seen. Proving viruses cause human cancer is "one of the 20th century's most significant scientific discoveries." #WomenInSTEM #WomensHistoryMonth

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

New research from Duke University School of Medicine and UNC‑Chapel Hill shows how TB bacteria survive inside granulomas by activating stress‑response genes. The findings offer new insight into long‑term infection. 🔗 Read more: https://medschool.duke.edu/news/genes-help-tb-survive #MedSky

Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!! Fantastic team effort ✨ #Tbsky #microsky

Mélanie Foulon@mel-foulon.bsky.social · 7mo ago

🚨 New preprint! Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬 Check it out: doi.org/10.64898/202...

#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR http://dlvr.it/TQjZ0W

Given the weather today, it’s time to repost my favorite phase diagram: Nakaya’s snow crystal morphology. We are towards the bottom right today. 🧪 ⚛️ #cryoEM

Excited to share work led by the wonderful Gopi Viswanathan examining roles of granuloma neutrophils &defining bacterial transcriptional profiles within mycobacterial granulomas. Cool collab with Qingyun Liu at UNC for evolutionary analysis of granuloma-specific genes www.science.org/doi/10.1126/...

Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas

Dual host-pathogen transcriptional profiling defines granuloma-specific programs during mycobacterial infection.

science.org

Human rights activist Rigoberta Menchú was born #OTD in 1959. She has dedicated her life to publicizing the rights of #Guatemala's Indigenous peoples & to promoting Indigenous rights globally. Deservingly, she was awarded the #Nobel Peace Prize in 1992 & is a UNESCO Goodwill Ambassador.

In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/... #InfectiousDisease

Conversations are a key tool for reimagining the world we want together, and curious exploration can make those conversations successful even when people don't agree

Good Conversations Don’t Require Everybody to Agree, Neuroscience Shows

Brain imaging is illuminating the patterns linked to productive, positive dialogue, and those insights could help people connect with others

scientificamerican.com

Published version up at @natcomms.nature.com New data with Aspergillus getting into tuberculous granulomas and growing like it's a member of the extended Myco family doi.org/10.1038/s414...

Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus - Nature Communications

Using the visually accessible zebrafish-mycobacterium infection model, Wee et al demonstrate the caseous necrotic core of mycobacterial granulomas provides a safe-haven for opportunistic pathogens to ...

doi.org

Stefan Oehlers@oehlerslab.org · last yr.

Why are prior and concurrent #TB such huge risk factors for M. abscessus infection? #zebrafish preprint lead by our research officer Denise Wee discovers tuberculous granulomas (yellow blob) act as a safe haven for opportunistic mycobacterial pathogens (magenta blobs).

Interested in Zebrafish brain imaging? We released a 3D printed mold that's is super helpful for us. Check it out Customizable FDM-based zebrafish embryo mold for live imaging www.biorxiv.org/content/10.1... Work by Marcela and Jaakko in the lab

A new study led by Harvard Chan School and @busph.bsky.social projects that U.S. funding cuts to global health aid will have a catastrophic effect on pediatric #tuberculosis.

U.S. funding cuts could result in nearly 9 million child tuberculosis cases, 1.5 million child deaths | Harvard T.H. Chan School of Public Health

A new Harvard Chan School and BUSPH study projects that U.S. funding cuts to global health aid will have a catastrophic effect on pediatric TB.

hsph.harvard.edu

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis. buff.ly/YOkDI4a

Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com

The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all

Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.

statnews.com

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

New Element in the Philosophy of Biology series—free to download until October 6! Walter Veit examines the role of models in evolutionary biology: their types, testability, and interrelations 👇📕 www.cambridge.org/core/element... #philsci #HPBio #evobio

Really interesting work from our neighbor Clare Smith @dukemedschool.bsky.social starting from CC mice and linking Ctsz to TB infection outcome as well as functional variation in human populations (UW, Case Western, Uganda) and expression in human granulomas (@charliejpyle.bsky.social)

PLOS Biology@plosbiology.org · 12mo ago

#Tuberculosis severity varies widely between people; why is this? This study uses the #CollaborativeCross mouse panel to identify the protease #cathepsin Z (CTSZ) as a conserved regulator of #TB outcomes via its influence on CXCL1 in mice & in humans @plosbiology.org 🧪 plos.io/4phwRA8