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Claus Ernst

@clausernst.bsky.social

Explainer video production: https://clausernst.com/en/ Moderate Long Covid since "mild" SARS-CoV-2 infection in Jan. 2021

755 Posts812 Follower 1176 Folgt

Jon Douglas @atranscendedman.bsky.social · yesterday

Researchers found that activating PD-1 directly suppressed inflammatory T cells in rheumatoid arthritis models and reduced harmful B cell formation, revealing an immune brake that treatment may be able to restore. www.nature.com/articles/s41...

PD-1 agonism puts the brakes on pathogenic T cell responses in RA - Nature Reviews Rheumatology

PD-L2-mediated activation of PD-1 signalling in rheumatoid arthritis suppresses pro-inflammatory cytokine production and regulates pathogenic B cell responses.

nature.com

Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 3d ago

A case study found a 25-year-old woman developed a rare blood vessel skin condition one month after COVID-19 infection. Researchers say it adds to growing evidence that COVID-19 can damage blood vessels and may trigger unusual vascular conditions after infection. www.cureus.com/articles/521...

An image showing a screenshot of an academic medical journal article from the Cureus Journal of Medical Science.
Article Text Elements
• Journal Title: The white text "Cureus Journal of Medical Science" is centered inside a teal rectangle banner.
• Article Title: The black, bold header reads, "Angioma Serpiginosum in a Young Woman Following COVID-19 Infection".
• Authors: The names Samantha R. Steiss, Sama Alazawi, and Scott A. Norton are written in blue text.
• Metadata: The text lists a publication date of "August 02, 2026" and a DOI link of "10.7759/cureus.113824".
• Badges: Two small rectangular badges below the date read "Open Access" with an orange padlock icon, and "Peer-Reviewed" with a grey checkmark icon.
Clinical Photograph
• Content: A front-facing view focusing on a patient's lower legs from the knees down to the ankles.
• Presentation: The skin across both shins and calves displays widespread, patchy, reddish-purple discolored lesions and macular rashes.

Long Covid Kids @longcovidkids.bsky.social · 4d ago

Summer newsletter take over by the youth editing team 👌 longcovidkids.org/so/aaP_rkGNW #editor #summer #writers

Welcome to the second issue of The Long Covid Chronic-Ill, the newsletter specifically made for children and young adults with Long Covid and overlapping illnesses. This is a safe space for everyone. ...

But first, meet the editors!

longcovidkids.org

Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 4d ago

In case this didn't get posted here.... Or I have already... And forgot😬🤦🏻‍♂️ www.cell.com/trends/endoc...

Long COVID: pathophysiological factors and abnormalities of coagulation

Coronavirus disease (COVID-19) is an airborne infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1]. It has had a disastrous effect on the world’s demograph...

cell.com

Christophe Veltsos @drinfosec.bsky.social · 4d ago

🚨🧵by Dr. @harryspoelstra.bsky.social on XTwitter: "🚨110 completely silent SARSCoV2 carriers walked into a hospital, zero symptoms, zero known contacts. Universal PCR screening caught them..." 🧵 threadreaderapp.com/thread/20835... #asymptomaticspread #NosocomialInfections

Universal SARS-CoV-2 RT-qPCR admission screening over 21 months in a German tertiary care hospital: detection of asymptomatic infections

🚨110 completely silent SARSCoV2 carriers walked into a hospital, zero symptoms, zero known contacts. Universal PCR screening caught them.

➡️Interesting German study confirming what many of us already know and are still warning for: #asymptomaticspread #NosocomialInfections

Chronic Illness Humor @chronicillness.bsky.social · 4d ago

"BUT YOU DON'T LOOK SICK!"

YEAH AND YOU DON'T LOOK LIKE A DOCTOR

Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 4d ago

"It is neglect of the highest order to look children in the eyes and say: 'We knew how to protect you, and we didn't do it.'" - Violet Affleck speech at the United Nations on September 23, 2025 Source: archive.md/0chiK

Claus Ernst @clausernst.bsky.social · 4d ago

Well well well. #POTS sharply on the rise since May 2020. #LongCOVID

Chart showing the search term “POTS” over time. Searches have been rising sharply since 2020.

Ralf Wittenbrink @ralfwittenbrink.bsky.social · 4d ago

Neue Studie: Long COVID durch anhaltende Immunreaktionen auf persistente virale Proteine gekennzeichnet Eine aktuelle Studie liefert neue Erkenntnisse darüber, dass Long COVID durch anhaltende Immunreaktionen auf persistente virale Proteine gekennzeichnet ist, was die Rolle …

valebodi.bsky.social @valebodi.bsky.social · 4d ago

Update from Dutch researcher Anouk Slaghekke in the AMS 9th annual research meeting abstract book (p. 12). This small study suggests that in #pwME and post CoV ME, the capillaries in the muscles do not deliver oxygen efficiently, even though heart and lung function are normal. 1

Slide from from Dutch researcher Anouk Slaghekke in the AMS 9th annual research meeting abstract book (p. 12). This study suggests that in #pwME and #LongCovid (the subgroup that develops post COVID-19 ME) the capillaries in muscles do not deliver oxygen efficiently, even though heart and lung function are normal.

Thanh Neville, MD, MSHS @thanh-neville.bsky.social · 5d ago

I agree with @drsandman11.medsky.social: If you didn't look like this & doing everything you can to prevent people from dying during the pandemic, maybe think twice before judging Dr. Fauci.

Dr. Karin Kelle-Herfurth @karin-kelle-herfurth.de · 5d ago

„Wann heilen wir ME/CFS?“ fragt Christopher Weingart im neuen Deutschlandfunk-Feature. Wir wissen es noch nicht. Aber die richtigen Anschlussfragen werden mehr. Hörenswert! Zur Lebensrealität schwer Erkrankter, zu klinischer Versorgung, gescheiterten Therapieversuchen und neuen Forschungsansätzen:

Wann heilen wir ME/CFS? Therapie und Irrtum (reizreduzierte Fassung Teil 1 und Teil 2)

Wie kommt die Forschung voran - und was hilft den Betroffenen, während sie auf Heilung warten? (Reizreduzierte Fassung Teil 1 und 2)

deutschlandfunk.de

Raul Krauthausen @raulkrauthausen.bsky.social · 5d ago

Auf unseren Demos sind fast immer nur behinderte Menschen. Wo bleibt ihr, liebe Verbündete?

Danielle Beckman @daniellebeckman.bsky.social · last wk.

One more nail in the coffin of the "it's just deconditioning" hypothesis. 60 days of strict bed rest ≠ #LongCOVID or #MECFS. Rob's group shows that while exercise capacity may be similarly reduced, the underlying skeletal muscle biology is VERY different. Time to move beyond outdated assumptions.

Nature Communications
Article in Press
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest

Tom Kindlon@tomkindlon.bsky.social · last wk.

Rob Wüst, corresponding author of the new paper: "Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest" www.nature.com/articles/s41... Link to his full post www.linkedin.com/posts/rob-w%... #MEcfs #LongCovid

Rob Wüst

• 2nd

Associate Professor | Vrije Universiteit Amsterdam | Physiology | Human Movement Sciences | Metabolism | Microscopy | Chronic Diseases

4h • Edited •

Connect

I am incredibly proud to share our latest study, published today in Nature Communications, as a follow-up from our 2024 Nature Communications paper.
https://lnkd.in/dij5WTNk

People with long COVID and ME/CFS are often told that their reduced exercise capacity and muscle abnormalities are simply the result of physical inactivity or “deconditioning.” We tested this assumption by comparing patients with healthy individuals who underwent 60 days of strict bed rest.

Although prolonged bed rest had major effects on physical fitness and skeletal muscle (see also: https://lnkd.in/dhx8JNQi), these changes were distinctly different from those observed in long COVID and ME/CFS. Our main conclusion: physical inactivity alone cannot explain the reduced exercise capacity and skeletal muscle abnormalities in these diseases.
This is important because it shows why a simple “just exercise more” approach does not reflect the underlying biology, particularly for people who experience post-exertional malaise. We need to understand the disease-specific mechanisms and develop safe, tailored treatments.

Ralf Wittenbrink @ralfwittenbrink.bsky.social · last wk.

Positiver Effekt der COVID-19-Impfung auf die Verringerung des Lungengefäß- und Atemwegsvolumens bei Patienten mit Long-COVID »Diese Studie zeigt erstmals, dass Patienten mit Long COVID, die trotz normaler Lungenfunktionswerte und unauffälliger konventioneller …

Abbildung 1. Funktionelle Atemwegsbildgebung (FRI) der Atemwege und der Lungengefäße bei gesunden, vollständig, teilweise oder nicht geimpften Personen mit Long COVID. Obere Reihe: FRI-Bilder des Bronchialbaums, die das intrapulmonale Atemwegsvolumen (IVAW) zeigen. Untere Reihe: FRI-Darstellung der Lungengefäße (unterteilt in kleine (rot), mittelgroße (gelb) und große Gefäße (blau)). Bei Long-COVID-Patienten zeigen sich kleinere Atemwegsvolumina und ein verringertes Gesamtblutvolumen in der Lunge sowie ein verringertes Blutvolumen in den kleinen Gefäßen.

Claus Ernst @clausernst.bsky.social · last wk.

'PsyLoCo'? What the fuck is wrong with the study authors?

ME/CFS Science@mecfsscience.org · last wk.

1) 🇩🇪 The results of the PsyLoCo study have been published. It tested group psychotherapeutic treatment in 48 Long Covid patients. The results showed no significant effect on symptoms, anxiety or depression.

Tom Kindlon @tomkindlon.bsky.social · last wk.

Dt. Ges. für ME/CFS @dgmecfs.bsky.social · last wk.

📻 Ein neues Deutschlandfunk-Feature zu #MECFS behandelt insb. die Therapieforschung & die Pathophysiologie von ME/CFS. Neben Betroffenen kommen u. a. Prof. Scheibenbogen & Dr. Astrid Weber zu Wort. www.deutschlandfunk.de/me-cfs-erschoepfungssyndrom-heilung-reizarme-version-teil-1-und-teil-2-100.html

Wann heilen wir ME/CFS? Therapie und Irrtum (reizreduzierte Fassung Teil 1 und Teil 2)

Wie kommt die Forschung voran - und was hilft den Betroffenen, während sie auf Heilung warten? (Reizreduzierte Fassung Teil 1 und 2)

deutschlandfunk.de

ME/CFS Science @mecfsscience.org · last wk.

1) 🇩🇪 There's now more info about the PIONEER study which will test inebilizumab (a drug that targets B-cells), in a subgroup of ME/CFS patients. It's a randomised trial at the Charité that aims to include 38 participants.

Screenshot of the trial registration for the PIONEER trial on inebilizumab

Chantal Britt @chantalbritt.bsky.social · last wk.

More than 6 years after the pandemic started, people with long covid and myalgic encephalomyelitis are still struggling to cope with their physical disabilities as well as the stigmatisation and psychologisation, while research, healthcare and support are inadequate. www.rts.ch/info/sante/2...

Six ans après la pandémie, que deviennent les malades du Covid long ?

Le 19 février dernier, un jeune Autrichien de 22 ans, Samuel, fait appel au suicide assisté pour mettre fin à sa "souffrance inimaginable" causée par le Covid long. Plus de six ans après le début de l...

rts.ch

Dr. McCoy 😷@drmccoy.info · last wk.

Für einen Terminüberblick zu Veranstaltungen der #LiegendDemo mit #Trauergang wegen #severeME #MECFS #LongCovid schaut gerne auf folgende Webseite: ➡️ liegenddemo.de/termine/ Dort könnt Ihr übersichtlich für Euch herausfiltern, welche Tage an welchen Orten für Euch in Frage kommen.

Alle Termine | Initiative #LiegendDemo

liegenddemo.de

Initiative LiegendDemo@liegenddemo.bsky.social · 2w ago

Am 08.08.2026 findet in Hamburg, zum Severe ME Awareness Day, ein Trauergang mit anschließender LiegendDemo statt. ✊️❤️

Dr David Joffe MB BS(Hons), PhD, FRACP @davidjoffe64.bsky.social · 2w ago

Because Cövid really isn't okay for kids... Specifically those yet to be borne www.nature.com/articles/s41...

The association of in utero SARS-CoV-2 exposure on neurodevelopmental outcomes at 12 and 22 months - Journal of Perinatology

Journal of Perinatology - The association of in utero SARS-CoV-2 exposure on neurodevelopmental outcomes at 12 and 22 months

nature.com

Ralf Wittenbrink @ralfwittenbrink.bsky.social · 2w ago

In Mexiko steigen die COVID-19-Fallzahlen und die (Test-)Positivität aktuell deutlich an. Die Positivität steigt auf 26 %, ähnliche Niveaus lagen nicht mehr vor seit der epidemiologischen Woche Nr. 33 des Jahres 2024. www.gob.mx/cms/uploads/...

Gráfica 1. Curva epidémica de casos confirmados y positividad por la COVID-19 por semana epidemiológica

dgspsoa.eurosky.social @dgspsoa.eurosky.social · 2w ago

bsky.app/profile/helm...

Helmholtz-Zentrum für Infektionsforschung (HZI)@helmholtzhzi.bsky.social · 2w ago

Das #EpsteinBarrVirus gilt als möglicher Auslöser für #MultipleSklerose. Doch warum entwickelt nur ein kleiner Teil der Infizierten die Autoimmunerkrankung? Eine neue Studie zeigt: Bestimmte T-Helferzellen reagieren besonders stark auf das #Virus. via #Tagesschau www.tagesschau.de/wissen/gesun...

Dr. McCoy 😷@drmccoy.info · 2w ago

Die untenstehende, berechtigte Fragestellung zu #Novavax #Nuvaxovid #XFG lässt sich heute mit Erscheinen der Juli #CHMP Meeting Highlights im positiven Sinne beantworten: Ja, endlich ist mal mit einer früheren Nuvaxovid-Verfügbarkeit als i.d. letzten Jahren zu rechnen: ➡️ bsky.app/profile/drmc...

Heidrun Wiesenmüller@hwiesenmueller.bsky.social · 3w ago

Gibt's schon einen Hinweis, wann der neue Nuvaxovid-Impfstoff zu erwarten ist? Wäre ja schön, wenn er mal etwas früher im Jahr käme.

Barbara Wimmer @shroombab.bsky.social · 2w ago

Jetzt gibt es mit den #MECFS Infos erstmals eine öffentliche Quelle des Ministeriums aus AT, auf auf die sich als Patient*innen, Anwält*innen, Ärzt*innen, Betroffene, Angehörige berufen können. www.gesundheit.gv.at/krankheiten/...

Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom (ME/CFS)

Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom (ME/CFS) ist eine chronische Erkrankung, die mehrere Körperfunktionen bzw. Organsysteme betrifft. Erfahren Sie mehr zu möglichen Ursachen, Symp...

gesundheit.gv.at

Claus Ernst @clausernst.bsky.social · 2w ago

www.technologynetworks.com/immunology/n...

The Epstein-Barr Virus Provokes T Cells To Drive Multiple Sclerosis

A study has revealed how the Epstein-Barr virus triggers T-cell responses that may drive autoimmunity in MS patients. Researchers showed how B-cell depleting therapy can calm this response, providing ...

technologynetworks.com

Tom Kindlon @tomkindlon.bsky.social · 2w ago

(Australia) Emerge Australia @emergeaustralia.bsky.social has partnered with Edith Cowan University (ECU) to measure the impact of ME/CFS and long COVID eaecu.au1.qualtrics.com/jfe/form/SV_... Screenshot from latest Emerge Australia email bulletin #MEcfs #LongCovid #PwME #CFS #ME #MyalgicE

Contribute to Research: Be Counted
Emerge Australia has partnered with Edith Cowan University (ECU) to measure the impact of ME/CFS and long COVID, and we need as many of you as possible to take part.

If you're an adult in Australia living with ME/CFS or long COVID, this is your chance to share what daily life is really like: the impact on your health, work, study, relationships, and access to support. Your story will feed into a published, peer-reviewed study: real evidence, that Emerge Australia, as well as researchers, advocates and policymakers, can point to for years to come.

A quick note on the name, because we know there's been confusion:

https://stratus.campaign-image.com.au/images/13664000008912003_zc_v1_1784090954140__4_hsw_sq.jpg

This ECU/Emerge Australia survey is separate from the recent announcement that ME/CFS will be included in AIHW's Australian Burden of Disease Study (ABDS) for the first time since 2003. That milestone is already locked in. This survey is about building the next wave of published evidence, so our community's needs keep getting stronger recognition in the years after, including in future AIHW reporting.

TAKE THE SURVEY AT YOUR OWN PACE

sibylle dahrendorf @sibylledahrendorf.bsky.social · 2w ago

Überlappende Krankheiten bei #ME #MEcfs. Ein Text von Christina Koch @juchti.bsky.social und mir, über #POTS #MCAS #SFN #CCI #EDS #Marfan #FQAD #PostVac #Borreliose #LongCovid und deren möglichen verheerenden Verkettungen. Link: medium.com/p/%C3%BCberl...