Incredibly proud to share our newest work where we developed a multiscale spatial transcriptomic atlas of the human amygdala using three complementary technologies! 1/12 🧵 www.biorxiv.org/content/10.6...

Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

The amygdala is a central hub for emotional learning that is dysregulated across numerous psychiatric disorders, yet its molecular architecture in humans remains poorly defined. We here present a spat...

biorxiv.org

New preprint from the lab about time time resolved ensemble computations and geometrical motifs that facilitate rapidly learned inference. skeeprint 🧵: 1/

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last mo.

Low-dimensional factorized neural computations underlie risk-adaptive choices https://www.biorxiv.org/content/10.64898/2026.08.12.744223v1

Neural Basis of Compositional Control www.nature.com/articles/s41...

Neural basis of compositional control - Nature

Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating p...

nature.com

🚨 📝 New preprint: Ephaptic coupling improves the neural population code Ephaptic coupling has always been a point of debate between the neural-code and the field-activity crowds. We find a network's own field improves its code, but the same field imposed from outside wrecks it. 👇(1/3)

Chemogenetics in people! Several clinical trials in the works... cen.acs.org/biological-c...

First human trials of designer protein therapies stun US neuroscientists

Chinese researchers are testing DREADDs, a gene therapy to turn down neuronal activity, in the clinic

cen.acs.org

HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neuro-cognitive Modeling https://www.biorxiv.org/content/10.64898/2026.06.05.730398v1

I've always hoped new model for science research would emerge, and this looks like a big step in that direction! alleninstitute.org/news/brain-h...

Brain Health accelerator to transform our understanding of brain disorders and develop new treatments

the global collaborative research initiative will initially target Alzheimer’s, Parkinson’s, Huntington’s disease, ALS, and Lewy body dementia

alleninstitute.org

How does your brain filter out the noise and focus enough to learn efficiently? In our newest preprint, we use intracranial recordings + computational modeling to explore how selective attention shapes learning and state representations in the human brain 🧠 www.biorxiv.org/content/10.6... 1/🧵

We are hiring! PhD student in Cognitive Computational Neuroscience at the Department of Psychology, University of Copenhagen, investigating the neural mechanisms of auditory imagination: jobportal.ku.dk/phd/?show=16... Project summary here: lundbeckfonden.com/neuronal-mec... Deadline: July 1st.

PhD position in cognitive computational neuroscience

jobportal.ku.dk

New paper with @paulm-k.bsky.social and Mark Stokes on how we switch internal attention between working memory contents. Beta-band oscillations tracked the magnitude and success of these switches. www.jneurosci.org/content/46/1... #neuroskyence

Human Beta Oscillations Reflect Magnitude and Fidelity of Priority Shifts in Working Memory

Flexible prioritization in working memory (WM) is supported by neural oscillations in frontal and sensory brain areas, but the roles of different oscillations remain poorly understood. Recordings in h...

jneurosci.org

Preprint alert! We've done the first ever wireless brain recordings from the high-level visual & motor regions (IT/PMv/PFC) in monkeys engaged in natural behaviors as well as during controlled screen-based tasks. Read below for a lay summary and the link for details! 1/8

Two postdoc opportunities @yale.edu in human neurophysiology. One position in my lab @wutsaiyale.bsky.social focusing on human cognitive neurophysiology. Details at helfrich-lab.com/news/ Plus a possible collab with anesthesiology 👇 #NeuroTwitter #NeuroJobs #neuroskyence #EEG Please share.

New work, now out in PLoS Biology. Using intracranial recordings & EEG, we find that the human STN rapidly engages / releases motor inhibition depending on task context, does so in tight accord w/ frontal cortex, and shows little to no lateralization while doing so. journals.plos.org/plosbiology/...

A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context

How does the human brain stop movements under realistic conditions? Using intracranial recordings and multi-variate EEG decoding, this study shows that a fronto-basal ganglia circuit featuring the sub...

journals.plos.org

Jan R. Wessel@janw.bsky.social · 8mo ago

New preprint from the lab, led by post-doc @cheolsoh.bsky.social and former post-doc Mario Hervault (now Asst Prof at UGrenoble). The boys used synchronous intracranial recordings from the human subthalamic nucleus & EEG to study β bursts during global & selective response inhibition. Details in 🧵

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

Big (belated) news: I’ve started a new role as a Human Neuroscientist at Nudge working on transcranial ultrasound stimulation! www.nudge.com

Nudge

Nudge - Whole-brain interfaces for everyday life

nudge.com

What's the relationship of apathy to depression and anhedonia? Sijia Zhao led our work on this to show that many individuals qualify for the diagnostic criteria of 2 or even 3 of these syndromes. But factor analysis reveals that the syndromes are highly dissociable jnnp.bmj.com/content/earl...

θθθ gang represent! We gee, seems like averaging firing rates without phase locking to theta is pretty important for uncovering value codes, who woulda thunk it? 🤔 This is a very fun and neat story that pulls together the theta worlds into value-based decision making.

Sebastijan Veselic@sebves.bsky.social · 6mo ago

1/n With Cosyne around the corner, I thought I would: a) make a thread about our “A cognitive map for value-guided choice in the vmPFC” Cell paper (i'm a bit late). shorturl.at/DBA3H

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

Revisiting the methodological foundation of lesion network mapping

Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...

doi.org

Toward model-based design of causal manipulations of brain circuits with high spatiotemporal precision doi.org/10.1016/j.co... #neuroscience

Closer to biology is good, and typical neurostimulation waveforms (square waves, sinusoids) are artificial and foreign to the brain. Here's a cool pilot study using endogenous EEG to construct more naturalistic ("endogenous) tACS stimulation patterns: www.brainstimjrnl.com/article/S193...

Establishing naturalistic brain stimulation targeting aperiodic EEG features: Transcranial Endogenous Current Stimulation (tECS)

Existing brain stimulation paradigms are based on synthetic waveforms, such as sinusoids, pulses, or band-limited noise1,2, which capture only narrow features of neural activity. These overlook the ri...

brainstimjrnl.com

This sounds crazy- 70% of studies on gaming addiction use scales that didn’t clarify that “games” doesn’t include gambling?? Now very curious about rates of true gaming addiction relative to what the confounded instruments show

Veli-Matti Karhulahti@mkarhulahti.bsky.social · 8mo ago

First post of the year, new paper out today: we present possibly the biggest case of systematic Measurement Schmeasurement in tech use. It seems that most studies on gaming (videogame) addiction/disorder haven't measured gaming after all. This research took years, so long 🧵 doi.org/10.1098/rsos...

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...

Ripple oscillations are central for memory and sleep. But ripple detection in humans remains challenging. Here we introduce a simulation approach in @natcomms.nature.com as common ripple detectors mainly pick up 1/f noise and not genuine oscillations 👇 www.nature.com/articles/s41... #neuroskyence

Aperiodic 1/f noise drives ripple activity in humans - Nature Communications

How aperiodic 1/f noise drives ripple activity in human brain and impacts on ripple detections is not fully understood. Here authors show that ripple detections should be driven by the 1/f noise, whic...

nature.com

Science is looking for somebody to do neuropixel recordings in formerly blind mice #neurojobs science.xyz/careers/neur...

Neuroscientist | Science Corporation

Science Corporation is a clinical-stage medical technology company.

science.xyz

Looks like Sam Altman et al launched their new #ultrasound based BCI company! merge.io/blog Also, computational neuroscientist role available 👀

With some trepidation, I'm putting this out into the world: gershmanlab.com/textbook.html It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class. My hope is that this will be a living document, continuously improved as I get feedback.

Hmmm, this suggests that the evidence for shortcut use as an indicator of applying a cognitive map seem to be weak even in humans. Maybe a cautionary note here for all the cognitive map studies where the map structure and metrics (e.g., hexagonal symmetry) are much more vague

Roddy Grieves@roddy-grieves.bsky.social · 9mo ago

Can humans & animals really use internal maps to take shortcuts? Tolman famously said yes - based largely on his Sunburst maze. Our new review & meta-analysis suggests evidence is far weaker than you might think. 🧵👇 doi.org/10.1111/ejn.... @uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!

Eiko Fried@eikofried.bsky.social · 9mo ago

Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity. www.nature.com/articles/s41...

for years, I've said my favorite conspiracy theory about the brain is that "neurons are a front, glial cells do all the real work", mostly (but not completely) as a joke. Welp... "Astrocyte ensembles are sufficient and necessary for recall" 👀👀👀 www.nature.com/articles/s41...

Astroengrams: rethinking the cellular substrate for memory

Nature Reviews Neuroscience - Recent evidence suggests that astrocytes, through coordinated activation in sparse ensembles, contribute to memory traces — termed ‘astro-neuronal...

nature.com