New perspective out @thelancetneuro.bsky.social w Anna Latorre, Marie Vidhailet et al. – where we further develop the idea that appendicular dystonia preferentially maps to BG networks while axial/cervical forms to cerebellar interations. Check it out here 👇👇 www.thelancet.com/journals/lan...

New lesion network mapping paper from the Berlin group (Stegemann et al.) on post-stroke pain in @ohbmofficial.bsky.social can serve as a good example in the whole LNM validity discussion: They describe a network associated with new severe pain after stroke. pubmed.ncbi.nlm.nih.gov/42420807/

Is brain circuit targeted TMS better than standard clinical TMS for treating depression? New study led by Joe Taylor @braincircuits.bsky.social out today in @jamapsychiatry.com says yes! Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression jamanetwork.com/journals/jam...

Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression

This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.

jamanetwork.com

Where do ideas come from? We founded the Night Science Institute with the mission of training in the creative scientific process every early-career scientist in the world. Help us to spread the word with this clip! www.youtube.com/watch?v=0c1V... @nightsciencepod.bsky.social

Night Science Institute - our story

YouTube video by Night Science Institute

youtube.com

Excited to present my poster "Genetic determinants of white matter hyperintensitiy spatial patterns" today at the #OHBM2026 Come by my poster to learn about a pragmatic approach to WMH spatial patterns and which genes may be involved 📌 #2733 🕐 12.45-13.45 h @institutvbhi.bsky.social

We are excited! #OHBM2026 – three @netstim.org papers by Aysu Sahin, Patricia Zvarova & Maike Mustin! 👇👇

Happy to share Lacuna, an open-source Python toolbox for brain lesion analysis. If you have lesion segmentation data (e.g., for infarcts, tumors) and want to know which brain regions and circuits it links to, it's built for you. lacuna-py.readthedocs.io #neuroskyence #OHBM2026

🚨 New Preprint! 🧠 We gave an AI model one simple rule: rearrange your neurons so that nearby ones respond alike. We never told it what a face, a voice, or a sentence was. It grew brain-like maps for all three anyway. 🧵👇 🌐 Website: topo-omni.epfl.ch

Excited to share our work at #OHBM2026! Come by poster 0198 to chat about lesion network mapping, predictive modeling and post-stroke cognitive impairment. 📍 Mon June 15, 14:45–15:45 📍 Tue June 16, 13:30–14:30 @ohbmofficial.bsky.social @ohbmtrainees.bsky.social

What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

Can lesion network mapping predict survival in children with brain tumors? Collaboration with UCL and @braincircuits.bsky.social in @nature.com suggests the answer is yes. Cutting the tumor off from this network may provide survival benefit. www.nature.com/articles/s41...

A prognostic human brain network for diffuse midline glioma - Nature

Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...

nature.com

New paper out in @ frontiersin.bsky.social 🧠 In 40,579 adults across two cohorts (HCHS, #ukbiobank), we show that "biological brain aging" on MRI links to poorer cognition & motor function — and mediates the link between vascular risk and functional decline. #neuroskyence #dementia #aging

Frontiers | Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals

IntroductionAge-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we inves...

doi.org

New paper out in @jimd-editors.bsky.social. In children with CLN2 disease — a form of childhood dementia — we show that brain atrophy on MRI tracks each child's clinical decline, making brain scans a promising tool to monitor treatment of this devastating, ultra-rare disorder. #pediatrics

Mapping Clinical Progression to Brain Atrophy in CLN2 Patients Under Cerliponase Alfa Treatment: A Prospective Neuroimaging Study

Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a lysosomal storage disorder, causes early childhood psychomotor regression, vision loss, seizures, and rapid progressive gray matter loss. Howev...

doi.org

New paper out in The Lancet @ebiomedicine.bsky.social on the oral–brain axis 🦷🧠. Does the bacterial community living in our gum pockets relate to brain health? In 1,026 people from the population-based PAROMIND cohort, we show the answer is yes. 🧵 #neuroskyence #microbiome #dementia

Subgingival microbiota composition is associated with brain health in the general population–the PAROMIND study

These findings from a large cohort advance the understanding of the oral microbiome–brain axis, highlighting specific microbial profiles linked to subclinical cognitive, structural, and inflammatory b...

thelancet.com

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Fantastic new tool to manage stimulation parameters and outcome scores in a machine readable and standardized fashion – a big step toward reproducibility in the field of DBS imaging! 👇👇

Lead-DBS@lead-dbs.org · 3mo ago

With SPARK-DBS, @savirmadan.bsky.social adds a new tool to the ecosystem of Lead-DBS: The small-scale databasing tool can store, analyze and integrate stimulation parameters and scores in BIDS-compliant fashion. Toward standardized data analysis in DBS! www.sciencedirect.com/science/arti...

My most recent and biggest work so far is finally out as a preprint! 🧠🧵 *Linking human brain functional connectivity to underlying neurotransmission* doi.org/10.64898/202... 1/n TL;DR below ↓ #neuroskyence #neuroimaging #MedSky #PsySciSky

A wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...

‘Overdue’ debate unfurls over neuroimaging method

After a January paper questioned the validity of an approach called lesion network mapping, its users are pressure testing their results.

thetransmitter.org

1/9 New preprint by Laurin Mordhorst: 3D histology validates 2D histology for axon radius distributions and conduction velocities. We asked: if individual axons vary along their length, can classic 2D histology still reflect white-matter organization? Link: www.biorxiv.org/content/10.6...

Correlating brain maps across datasets is everywhere in neuroimaging. Here we ask: when you contextualize a brain map against genes, metabolism, or connectivity... What can you really conclude? How can we do better? We explore these questions here: tinyurl.com/2dudkevc

Opportunities and pitfalls of data contextualization in neuroimaging - Nature Reviews Neuroscience

Despite rapid exploitation of the opportunities that contextualization of brain maps affords, potential limitations have received little attention. In this Roadmap, Royer et al. provide practical guid...

tinyurl.com

The LNM debate keeps developing. www.nature.com/articles/s41... @andrewzalesky.bsky.social @natneuro.nature.com #neuroskyence

Null models for lesion network mapping - Nature Neuroscience

Van den Heuvel et al. show that lesion-network mapping (LNM)-derived circuits converge across disorders and argue that this convergence reflects a fundamental methodological limitation of LNM. We eval...

nature.com

Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10

🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8

I couldn't find a tool to plot different #neuroimaging data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a #Python package for (sub)cortex & tracts.🧠 - Simple API - Built-in atlases - Custom atlas support 🔗 github.com/teanijarv/ya... (drop a ⭐️!)

neuromapr 0.2.1 has been accepted and published on CRAN! Very excited to get this out to users in the simplest way possible, and hope the #rstats #neuroimaging community finds it useful! lcbc-uio.github.io/neuromapr/

Spatial Null Models and Transforms for Brain Map Comparison

Implements spatial null models and coordinate-space transformations for statistical comparison of brain maps, following the framework described in Markello et al. (2022)…

lcbc-uio.github.io

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

Michael Fox@foxmdphd.bsky.social · 5mo ago

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

📢 DGKN 2026: Congress for Clinical Neurosciences with Continuing Education Academy 📅on 25 February 2026, Prof. Dr. Thomas Wolfers will present a talk titled: “𝗠𝗮𝗰𝗵𝗶𝗻𝗲 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗮𝗻𝗱 𝗕𝗶𝗴 𝗗𝗮𝘁𝗮 𝘁𝗼 𝗣𝗮𝗿𝘀𝗲 𝗜𝗻𝗱𝗶𝘃𝗶𝗱𝘂𝗮𝗹 𝗗𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀” @thomaswolfers.bsky.social #DGKN2026 #ClinicalNeuroscience #BigData #ML

New preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.

Revisiting the methodological foundation of lesion network mapping

Lesion network mapping (LNM) links focal brain lesions to distributed neural circuits by projecting lesion locations through a normative functional connectome. van den Heuvel and colleagues recently s...

doi.org