Tessera
Folgen

Dr Rebecca Coll

@colllab.bsky.social

Lecturer in Immunobiology at QUB - innate immunity, inflammasome, NLRP3, dose response curve, and bad pun enthusiast. Views expressed are mine alone.

39 Posts991 Follower328 Folgt
Dr Rebecca Coll@colllab.bsky.social · last mo.

I'm super proud that our work using iPSC-derived macrophages as a model for human inflammasome signalling is now online in Cell Reports Methods. I hope we can convince you that these are a great cell model for studying therapeutically relevant inflammatory pathways! www.cell.com/cell-reports...

Induced pluripotent stem cell-derived macrophages enable broad modeling of human inflammasome signaling

Current in vitro macrophage models have limitations for studying inflammasome function. McKee et al. demonstrate that iPSC-derived macrophages are broadly comparable to monocyte-derived macrophages in...

cell.com

Dr Rebecca Coll@colllab.bsky.social · 11mo ago

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine@jem.org · 11mo ago

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

David Wearing@davidwearing.bsky.social · last yr.

Absolutely dystopian juxtaposition from the Guardian front page. Difficult to understand how anyone of decency and conscience can defend this government at this point. Just sheer moral degeneracy to arm a state that does this and arrest people for objecting. Wtf are we doing as a country?

Bild
Broz Lab@brozlab.bsky.social · last yr.

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

embopress.org

Inflammasome Lab@inflammasomelab.bsky.social · last yr.

Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...

shorturl.at

Eva Frickel@frickellab.bsky.social · last yr.

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!

Dr Rebecca Coll@colllab.bsky.social · last yr.

We are recruiting a student for a really exciting PhD project on understanding how high plasma suPAR predicts poor outcome in patients with ARDS @wwiem-qub.bsky.social #ARDS #criticialcare - any questions please get in touch! (open to UK and RoI) www.findaphd.com/phds/project...

Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast on FindAPhD.com

PhD Project - Understanding how high plasma soluble urokinase plasminogen activator receptor (suPAR) predicts poor outcome in patients with ARDS. at Queen’s University Belfast, listed on FindAPhD.com

findaphd.com

Dr Rebecca Coll@colllab.bsky.social · last yr.

Brilliant and elegant work from @jelenalab.bsky.social - showing yet again the complexity of how our immune system keeps itself in check!!

JelenaBezbradicaLab@jelenalab.bsky.social · last yr.

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

'New insights into the noncanonical inflammasome point to caspase-4 as a druggable target' Progress article by Elad Elkayam, Francois Gervais, Hao Wu, Michael Crackower & Judy Lieberman @harvardmed.bsky.social @bostonchildrens.bsky.social #inflammasome #immunology #immunosky

New insights into the noncanonical inflammasome point to caspase-4 as a druggable target - Nature Reviews Immunology

This Progress article describes recent studies showing that the human lipopolysaccharide sensor caspase-4 activates pro-IL-18 and causes vascular leakage by inducing pyroptosis in endothelial cells. S...

nature.com