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Franklin_LAB

@franklinlab.bsky.social

We are at the Institute of Innate Immunity, University of Bonn, Germany. Interests: Innate immunity, Inflammasomes, Thrombo-inflammation, autoimmunity, and Data Science.

26 Posts727 Follower648 Folgt
Franklin_LAB@franklinlab.bsky.social · 5mo ago

Happy to share (and proud to have contributed) to this new PDAC paper on ASC/PYCARD: cancer-cell ASC links innate immunity to mitochondrial metabolism—and extracellular ASC speck targeting with nanobodies suppresses tumorigenesis in vivo. 🤩 www.nature.com/articles/s41...

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer - Nature Communications

The role of the innate immune system in pancreatic cancer is largely unexplored. Here, the authors reveal a targetable cancer cell-intrinsic axis in pancreatic cancer comprising ASC inflammasome compl...

nature.com

Franklin_LAB@franklinlab.bsky.social · 8mo ago

I kind of suspected this non-lytical IL-1b secretion by viable cells was BS... www.nature.com/articles/s41... "...So, the long-suspected ‘non-canonical’ secretion pathways, invoking unconventional secretion routes, atypical inflammasome regulation, are probably a misinterpretation artefact..."

A few cells make the difference in monocyte interleukin release - Nature Immunology

Single-cell analysis shows that the release of interleukin-1β in human monocytes arises from a small subset of pyroptotic cells, rather than from non-canonical secretion pathways.

nature.com

Andres Hidalgo@drusqui.bsky.social · 9mo ago

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Nature Reviews Immunology@natrevimmunol.nature.com · 9mo ago

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

Franklin_LAB@franklinlab.bsky.social · last yr.

We are happy to announce the second edition of the Joint Symposium of the Brazilian (SBI) and German (DGfI) Societies for Immunology. The event will happen in Vienna, Austria August 15-16, 2025, and will bring together Brazilian and German immunologists.

Ivan Zanoni@lozanzi.bsky.social · last yr.

#WeekendRead. #EveryOrganIsAnImmuneOrgan. Medei &co show @naturecvr.bsky.social that IL1b initiates a positive feedback loop leading to IL1b production by, & response of, cardiac resident macrophages which drives atrial fibrillation. Targeting resident macrophages is protective. #ScienceSavesLives

IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression - Nature Cardiovascular Research

Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various ris...

nature.com

Iva Hafner Bratkovič@ivahb.bsky.social · 2y ago

As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek. www.nature.com/articles/s41...

Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications

‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...

nature.com

Miguel Reina-Campos@reinacampos.bsky.social · 2y ago

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature

Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

nature.com

Gabriele Pollara@gpollara.bsky.social · 2y ago

This is a cool story - spatial proteomics to identify over-expressed pathways (type I IFN & JAK/STAT) proposing new therapies (JAKi) for Toxic Epidermal Necrolysis 🌟 Discovery science translated into clincial benfit. Love it! 🌟 #MedSky 🧪 #ImmunoSky #dermatology www.nature.com/artic...

Spatial proteomics identifies JAKi as treatment for a lethal skin disease

Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

nature.com

Ivan Zanoni@lozanzi.bsky.social · 2y ago

#WeekendRead #FungiPower! Liao Gao Iliev &co show @ Nature that the stomach of wild, not lab, mice is colonized by an immunosilent fungus! Mucus alterations via diet or antibiotics drive a Th2 -not Th17- response that worsens allergy but protects against parasites! doi.org/10.1038/s41586-024-08213-2

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature

Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

doi.org

Franklin_LAB@franklinlab.bsky.social · 2y ago

A study in @natureportfolio.bsky.social shows how cancer cells subvert monocyte function to prevent effective T cell activation. This finding sheds light on a novel mechanism of immune evasion employed by tumors. www.nature.com/articles/s41...

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature

Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

nature.com