Excited to share our new study characterizing spatial gene expression in the human NAc led by @prashanthi-ravi.bsky.social @svitlanabach.bsky.social @rphillips3.bsky.social in collaboration with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social @lcolladotor.bsky.social.

Neuron@cp-neuron.bsky.social · last mo.

New paper out online today!! We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk. www.nature.com/articles/s41...

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus - Molecular Psychiatry

Molecular Psychiatry - BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus

nature.com

Thrilled to share that our latest paper investigating how mPFC-LC projectors contribute to sustained #attention is now out in @npp-journal.bsky.social This is so meaningful to me and the team, Its @rehg-j.bsky.social first first-author paper and my first corresponding one. rdcu.be/fqBJp

Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

rdcu.be

Congrats to Jiseok Lee and others in @hyejungwon.bsky.social lab on this set of exciting findings that begin to explain how common variants in schizophrenia mediate functional effects. Honored for our teams to have played a role and to see our new SCZ data get integrated into a study so quickly!!

Cedric Boeckx@cedricboeckx.bsky.social · 2mo ago

Fascinating new work linking schizophrenia to cilia By @hyejungwon.bsky.social @martinowk.bsky.social @stephaniehicks.bsky.social @kr-maynard.bsky.social “first in-vivo characterization of the consequence of common variant architecture in SCZ; ciliary dysfunction as a convergent mechanism” 🧪🧬🧠

Excited to see this preprint from @drjennkim.bsky.social @kr-maynard.bsky.social, Annie Ciernia and colleagues. I've highlighted this approach and toolset in several recent talks: spatial transcriptomics isn't just about the gene expression - www.biorxiv.org/content/10.6...

Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detection

Microglia exhibit a dynamic range of morphologies that actively shift in response to local environmental cues. There has been a concerted effort as a field to move away from dualistic characterization...

biorxiv.org

Huge congratulations to newest PhD from our group @shkwon-bcmbneuro.bsky.social after thesis defense, "Spatial gene expression landscape of the human cortex in health and disease". Really grateful for the hard work, dedication and commitment to many, many projects, and the team science spirit.

My main PhD work was just published in Nature! We studied the developmental risk factors for a pediatric brain tumor called ependymoma. The subtype we study is driven by the ZFTA-RELA fusion oncoprotein, a potent but ependymoma-specific cancer driver. www.nature.com/articles/s41...

Dominant clones leverage developmental epigenomic states to drive ependymoma - Nature

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of...

nature.com

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

New postdoctoral opportunity @lieberinstitute.bsky.social working w/ @tsawada1.bsky.social and our Molecular Neurogenetics team using human induced pluripotent stem cells to investigate molecular, cellular and neuroendocrine mechanisms by which impaired placental function impacts brain development

Now online! @lieberinstitute.bsky.social & @jhubiostat.bsky.social collaboration generating important resource (Visium & Xenium) on molecular organization of human hypothalamus w/ cool findings associating sex differential expression to neuropsychiatric disorders 🧠🔬🧪 www.cell.com/cell-reports...

Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus

The ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ...

cell.com

Honored to be appointed Chief Scientific Officer @lieberinstitute.bsky.social. LIBD is a uniquely collaborative place with extraordinary biological resources and a commitment to translation 🧠🔬🧪. Grateful to my colleagues and excited to help guide our next chapter! www.libd.org/keri-martino...

Keri Martinowich, Ph.D., Chief Scientific Officer | The Lieber Institute for Brain Development | Research & Discovery

Lieber Institute for Brain Development Appoints Keri Martinowich, Ph.D., as Chief Scientific Officer Baltimore, MD (January 6, 2025) — The Lieber Institute for Brain Development (LIBD) announced the a...

libd.org

Excited to be headed to my first @acnporg.bsky.social meeting! Stop by my talk to hear about D1-islands in the human NAc or my poster to hear about our efforts to use spatial transcriptomics to profile lateral septum neurons in the human brain.

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention. 1/7 www.biorxiv.org/content/10.6...

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...

biorxiv.org

This dataset is paired with a spatial transcriptomic analysis of the locus coeruleus from the same donors. This work led by @berniejmulvey.bsky.social is also now in pre-print! bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v www.biorxiv.org/content/10.1...

Bernie Mulvey@berniejmulvey.bsky.social · 9mo ago

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025... Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉 Check it out here: doi.org/10.1093/narg... #NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics

Congratulations to Michael Gandal, M.D., Ph.D. on being awarded the 2025 Eva King Killam Research Award! 👏 #ACNP2026 Please click here ➡️ tinyurl.com/52447muh to watch the acceptance video by Michael Gandal, M.D., Ph.D.

Congratulations to Ian Maze, Ph.D. and Erin Calipari, Ph.D. for being awarded the Daniel H. Efron Research Award. 🎉#ACNP2026

Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA. Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions). It’s been a joy working with you @estellayixingdong.bsky.social!

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 9mo ago

Orchestrating Spatial Transcriptomics Analysis with Bioconductor https://www.biorxiv.org/content/10.1101/2025.11.20.688607v1

Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠 I'm there too - get in touch!

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry

Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

doi.org

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry

Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

nature.com

Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41... #Calicumimaging #miniscopes #rCPT #PrL

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry

Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

nature.com

Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.

Louise Huuki-Myers@lahuuki.bsky.social · 9mo ago

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience recruiting.paylocity.com/recruiting/j...

Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience

A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...

recruiting.paylocity.com

New Hot Topics piece from @rphillips3.bsky.social and Stephanie Page in @npp-journal.bsky.social describing emerging insights on roles of molecularly-defined cell types in the lateral septum, which serves as a hub for coordinating diverse social behaviors. www.nature.com/articles/s41...

Role of molecularly defined lateral septum cell types and circuits in social behaviors - Neuropsychopharmacology

Neuropsychopharmacology - Role of molecularly defined lateral septum cell types and circuits in social behaviors

nature.com

For #FluorescenceFriday✨ Exploring the beauty of the locus Coeruleus using IF staining: neurons🔵 surrounded by glowing astrocytes🟢 embracing delicate blood vessels🔴, alongside striking pTau signals💗. A vivid reminder of the cellular complexity shaping brain health and disease. #LC #Neuroscience

Excited to share this new work from the lab, in collaboration with @jtuscher.bsky.social & Rob Sorge! Here, we used single cell transcriptional profiling to define molecular adaptations induced by chronic pain and opioid experience, which often occur in conjunction. www.biorxiv.org/content/10.1...

A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.

science.org

Excited to be co-chairing this @acnporg.bsky.social panel with chair @kr-maynard.bsky.social on opioid-responsive subpopulations in brain reward circuits. Special thanks to @rphillips3.bsky.social for helping to assemble the panel!