CRC 1064 Chromatin Dynamics
@crc1064.bsky.social
Munich research consortium focusing on chromatin dynamics.
🕤 With just a few weeks to go until our 𝘴𝘺𝘮𝘱𝘰𝘴𝘪𝘶𝘮 "𝗗𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆, 𝗜𝗱𝗲𝗻𝘁𝗶𝘁𝘆 & 𝗙𝗮𝘁𝗲 𝗮𝘁 𝗕𝗶𝗼𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀" on 8 July 2026 at the Biomedical Center @lmu.de we are pleased to introduce our second speaker Miquel Pleitez. ❗ Free registration is required until 24th June: www.med.lmu.de/bmc/en/news/...
In the most recent episode we talked with Peter Becker from the @bmc-lmu.bsky.social about his successful career in Epigenetics, where he discovered the chromatin remodeler ISWI and dosage compensation complex MOF. #podcast #epigenetics Listen here: www.activemotif.com/podcasts-pet...
⏱️ As we count down to our 𝘴𝘺𝘮𝘱𝘰𝘴𝘪𝘶𝘮 "𝗗𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆, 𝗜𝗱𝗲𝗻𝘁𝗶𝘁𝘆 & 𝗙𝗮𝘁𝗲 𝗮𝘁 𝗕𝗶𝗼𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀" on 08.07.26 at BMC @lmu.de we are introducing (next post) our speaker. ❗ Registration is required until 24th June! www.med.lmu.de/bmc/en/news/... Today, we are pleased to highlight Jennifer Altomonte @tum.de :
Symposium: Diversity, Identity & Fate at Biomedical Frontiers
Diversity in research and talent promotes excellence in science.
med.lmu.de
📆 SAVE THE DATE: 8th July 2026 @ Biomedical Center Munich 𝟮𝗻𝗱 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺: 𝗗𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆, 𝗜𝗱𝗲𝗻𝘁𝗶𝘁𝘆 & 𝗙𝗮𝘁𝗲 𝗮𝘁 𝗕𝗶𝗼𝗺𝗲𝗱𝗶𝗰𝗮𝗹 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀 𝘚𝘤𝘪𝘦𝘯𝘵𝘪𝘧𝘪𝘤 𝘦𝘹𝘤𝘦𝘭𝘭𝘦𝘯𝘤𝘦 𝘪𝘴 𝘣𝘦𝘴𝘵 𝘧𝘰𝘴𝘵𝘦𝘳𝘦𝘥 𝘣𝘺 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩𝘦𝘳𝘴 𝘸𝘪𝘵𝘩 𝘥𝘪𝘷𝘦𝘳𝘴𝘦 𝘢𝘤𝘢𝘥𝘦𝘮𝘪𝘤 𝘢𝘯𝘥 𝘤𝘶𝘭𝘵𝘶𝘳𝘢𝘭 𝘣𝘢𝘤𝘬𝘨𝘳𝘰𝘶𝘯𝘥𝘴... Registration: www.med.lmu.de/bmc/en/news/...
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7
nature.com
Excited for this new preprint from my lab where we unexpectedly found a role for methionine synthase reductase in regulating heterochromatin independently of methionine synthesis 👇
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 8mo agoMethionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis https://www.biorxiv.org/content/10.64898/2025.12.19.695597v1
Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...
cell.com
Menno Schilthuizen @schilthuizen.bsky.social gave a brilliant overview of the interplay between genetic diversity and reproductive isolation in speciation, followed by a discussion with science historian Kärin Nickelsen and biochemist Axel Imhof @bmc-lmu.bsky.social. Chair: @lenabouman.bsky.social
Center for Advanced Studies@caslmu.bsky.social · 9mo ago🧬 The Speciation Puzzle: Diversity, Isolation, and Genetic Resilience Join us on Thursday, Nov 13, at 7 PM for a fascinating discussion with Menno Schilthuizen @schilthuizen.bsky.social, Kärin Nickelsen @lmumuenchen.bsky.social & Axel Imhof @bmc-lmu.bsky.social. www.cas.lmu.de/en/events/ev...
I feel extremely honoured for this recognition. Thanks go to many people from my lab and colleagues for their trust and support over the years
Helmholtz Munich@helmholtzmunich.bsky.social · 8mo ago👏 Prof. Maria-Elena Torres-Padilla, this year’s Leibniz Prize laureate, has now been honored with the Bavarian #Maximiliansorden for Science and Art. 👉 Read more: t1p.de/d5vq0 @metorrespadilla.bsky.social @epihmgu.bsky.social @pioneercampus.bsky.social #StemCells #Epigenetics
We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon. Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
rdcu.be
🌍 The #HelmholtzMunich Talent Forum 2025 brought together exceptional early-career scientists in #epigenetics & nucleic acids research to foster exchange, collaboration & research excellence. 👩🔬👨🔬 👉 t1p.de/3dsix @boyanbonev.bsky.social @epihmgu.bsky.social #TalentForum
The Helmholtz Munich Talent Forum (Nov 18–19) brought 8 emerging global talents in epigenetics & nucleic acids research to our Neuherberg Campus! Inspiring talks, a keynote by @boyanbonev.bsky.social & vibrant networking—science at its best! bit.ly/4o2ftxr
🔬 Exploring Frontiers in Epigenetics & Nucleic Acids Join us @ Talent Forum 2025 – a 2-day symposium spotlighting top early-career researchers. 📅 Nov 18–19 | Helmholtz Munich 🎙 Keynote: Prof. Boyan Bonev 🌍 Speakers from around the world 🎟 Free registration: www.helmholtz-munich.de/stem-cell-ce...
“Translating complex science into something simple, yet meaningful is never easy.” 💬 Our #EpiCrossBorders PhD researchers are learning just that — turning #epigenetics into connection, curiosity & conversation at the Deutsches Museum. 📍14–16 Nov | #StemCellStories #SciComm #PhDLife
🧬 From 14–16 Nov, join us at the #DeutschesMuseum for “Stem Cell Stories” — an interactive exhibition on stem cells, identity & epigenetics. 🎙️ Roundtable discussion on #AI in stem cell research & its ethical challenges on 📅14 Nov ⏲️18:30. #StemCells #Epigenetics #AIinBiomedicine #HelmholtzMunich
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression. www.biorxiv.org/cgi/content/...
Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
biorxiv.org
Check out our pre-print on how the human INO80 complex acts on nucleosomes and hexasomes: PostDocs Priyanka & Manmohan et al. solved structures of INO80 bound to several substrates and completed missing questions about similarities of modes of actions across species🧬 www.biorxiv.org/content/10.1...
Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex
The ATP-dependent INO80 chromatin remodeller slides and repositions nucleosomes to shape and maintain chromatin around gene regulatory elements and replication origins. Recent work uncovered capabilit...
biorxiv.org
#Jobalert 🚨: Please RT ! Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism: How do (nuclear) metabolic enzymes reguate chromatin function ? #epigenomics, #epigenetics, #metabolism www.helmholtz-munich.de/en/ife/job-o...
🎙️ Chromatin and Neurodevelopment: An Interview with Prof M. Felicia Basilicata 🎙️ We are pleased to welcome Prof Basilicata, who joined our BMC as LMU Professor of #Molecular #Gene #Regulation on 1st Sep. 🧬 Read the interview ➡️ lnkd.in/eR9ptAWf Foto: BMC / #chromatin #neurodevelopment #disorder
Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability - Nature Communications
The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...
nature.com
Julian Stingele@jstingele.bsky.social · 2y agoHappy to share our latest work🍾 🥳 PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
🥳Congratulations, Shubo! 🥂👏What a fantastic start to your scientific career! Shubo Zhao @jstingele.bsky.social receives Promotion Award from the Münchner Universitätsgesellschaft: www.genzentrum.uni-muenchen.de/news-events/... MUG prizes for LMU early-career researchers www.lmu.de/en/newsroom/...
MUG prizes for LMU early-career researchers
This year, six doctoral graduates and two habilitation graduates are receiving awards from the Munich University Association.
lmu.de
📢 Advance Your Career: Apply by July 31 to speak at the #TalentForum at #HelmholtzMunich! #PostDoc aiming for a group leader role? Present your work in #Epigenetics & Nucleic Acids Research and connect with leaders in the field. 🗓️ Nov 18–19, 2025, Munich ⏳Deadline: July 31, 2025 👉 t1p.de/n2n2r
🎉 Join us at the upcoming GfG Symposium "Epigenetics & Chromatin" in Giessen, Sept 24–26, 2025! Amazing speakers, low registration fee, € 300 prizes for best poster & short talk, + free GfG membership for non-members. Please RT! express.converia.de/frontend/ind...
Welche Bedeutung hat Künstliche Intelligenz für #OpenScience? Was wird dazu in der wissenschaftlichen Community diskutiert? Diesen Fragen widmen sich 3 Blog-Beiträge von DFG-Kolleg*innen für das Projekt "Open Access Network", wo nächste Woche bereits der dritte erscheint. ▶️ open-access.network/blog
🎤 Apply to speak @our TALENT FORUM by July 31! Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists 🧳Travel+accommodation covered if selected! 📝 Info+how to apply: lnkd.in/drkRvz7N #postdoc #career #groupleader #HelmholtzMunich #research
#WissenschaftlicheIntegritaet: Welche Kriterien sind eigentlich für die Bewertung der #Leistung von Wissenschaftler*innen relevant? Den mehrdimensionalen Ansatz und Fragen rund um #Leistungsdimension und #Bewertungskriterien (er)klärt unser #GWP-Kodex in Leitlinie 5: fcld.ly/leitlinie5
Leistungsdimensionen und Bewertungskriterien - Wissenschaftliche Integrität
Für die Bewertung der Leistung von Wissenschaftler*innen ist ein mehrdimensionaler Ansatz erforderlich: Neben der wissenschaftlichen Leistung können weitere Aspekte Berücksichtigung finden. Die Bewert...
fcld.ly
Hear, hear, one of the most remarkable colleagues (and dearest friends) I've had just became Dr Pal!!! My warmest congratulations to you Mrinmoy, and can't wait to see all the amazing things you will do in the future!!!
Mrinmoy@palmrinmoy.bsky.social · last yr.Defended my PhD last week! It’s been an incredible journey filled with challenges and exciting science. I'm deeply grateful to everyone who was part of it -especially @metorrespadilla.bsky.social for taking me on this ride. #PhDone 🎓
CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors & co-repressors that balances the expression of inflammatory genes @www.helmholtz-munich.de @franzigmuc.bsky.social @crc1064.bsky.social @tum.de www.life-science-alliance.org/content/8/8/...
Our closing CRC 1064 Chromatin Days (May 26–27) brought together past & present members for inspiring talks, posters, and a celebration of 12 years of collaboration. Huge thanks to all speakers, contributors & participants—what a send-off! The IRTG lives on 🎉 #ChromatinDays #ScienceCommunity #Munich
