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Christy Niemeyer, PhD

@csniemeyerphd.bsky.social

Assistant Professor and Principal Investigator @ CU Anschutz, Dept. of Neurology. Neuroscientist, Neurovirologist, Science Advocate

6 Posts256 Follower543 Folgt
Nature Microbiology@natmicrobiol.nature.com · 2y ago

OUT NOW: Human enteric α-defensin 5 interacts with colonic epithelial receptor P2Y11 to induce filopodia and promote Shigella infection by Kai Ye & co www.nature.com/articles/s41...

Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11 - Nature Microbiology

HD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection.

nature.com

Katie Mack@astrokatie.com · 2y ago

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

White House pauses all federal grants, sparking confusion

The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

washingtonpost.com

Jimmy Dooley@jimmycdooley.bsky.social · 2y ago

Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art. Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed Morales-Botello et al., 2012

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Monica Carson@brainimmunity.bsky.social · 2y ago

How much of age associated #microglia dysfunction in #Alzheimers disease is due to activation of LINE retrotransposons? Fun #openaccess study exploring this hypothesis - worth a read. #neuroinflammation #neurosky

Marta Olah, PhD@martikacska.bsky.social · 2y ago

Super excited to be here and to start using this platform with a great news - check out the latest study from the Sher lab published in Acta Neuropathologica reporting on the effect of LINE-1 retrotransposons on microglial function in Alzheimer’s disease 🙂 link.springer.com/article/10.1...

Monica Carson@brainimmunity.bsky.social · 2y ago

In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI # neuroskyence

bioRxiv Immunology@biorxiv-immuno.bsky.social · 2y ago

Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury https://www.biorxiv.org/content/10.1101/2024.11.18.624186v1

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · 2y ago

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

science.org

Ewan St. John Smith@psalmotoxin.bsky.social · 2y ago

👏 to Tetsuo Hasegawa & others of Clatworthy lab & beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch www.nature.com/articles/s41...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology

Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

nature.com

Monica Carson@brainimmunity.bsky.social · 2y ago

This threaded discussion on sex differences in mechanisms leading to Alzheimer’s disease and neurodegeneration is worth a read. #microglia, #neuroinflammation

Rachel Buckley, PhD@bucklr01.bsky.social · 2y ago

You hit the NAIL ON THE HEAD, Simon. While women and men might 'get there' together, the biological pathways are sometimes (not always) vastly different. There is increasing evidence of immune pathways being implicated (doi.org/10.1093/brai... as one ex). So much more that needs to be discovered.

Andrew Mendiola@andrewmendiola.bsky.social · 2y ago

I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.

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