Das alles fühlt sich zunehmend wie ein „Don‘t look up“-LARP an. 🫤

light-activated tetanus neurotoxin (LATeNT) by the @aliceyting.bsky.social lab. Includes a comparison with the light-switchable PdCO (www.nature.com/articles/s41...), showing a long lasting inhibition for 1h hour post illumination. www.nature.com/articles/s41...

Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo - Nature Methods

LATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo...

nature.com

Finally out in @natneuro.nature.com! A forgotten memory isn't always gone. We show that forgotten memories persist as silent memory traces, can be recovered by reminders, and can even be reconstructed into false memories. Excited to finally share this work! www.nature.com/articles/s41...

The apical dendrite looks great, and does wonders in a slice. What does it do in the living cortex? It depends on the cell. A causal spatial role for apical dendrites in the cortex www.biorxiv.org/content/10.6... by @anyiliu.bsky.social with @kenneth-harris.bsky.social and @fedrossi.bsky.social

The Neuroscience Department at UC Berkeley is hiring an Asst Professor in Computational Neuro. All areas of computational/theoretical neuro are welcome. Deadline Oct 30. Join our neuroscience community! aprecruit.berkeley.edu/JPF05446 #AcademicJobs #Neuroscience #NeuroJobs

Assistant Professor - Computational Neuroscience - Department of Neuroscience

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

@ptrrupprecht.bsky.social providing the new go-to GECI reference. Read when doing calcium imaging. rdcu.be/fwF82

Spike inference from calcium imaging data acquired with GCaMP8 indicators

Nature Methods - In this Analysis, Rupprecht et al. investigate the behavior of GCaMP8 variants in spike inference using several different algorithms. They highlight the role of the...

rdcu.be

If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...

Climbing fibers encode the gradient of a loss function for the cerebellum

Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...

biorxiv.org

Che-Hang brought the Ventana, and @ianoldenburg.bsky.social brought the holography. All-optical 2p neurophysiology @cshlcourses.bsky.social A great collab. Summer courses are the best.

Two-photon calcium imaging. What makes for good data? How can we optimize experiments to get good data? New post labrigger.com/blog/2026/07... and new free web apps from @filip-tomaska.bsky.social (1/8)

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

We get asked often - what is the duration of psilocybin's effects in the mouse brain? 🧠 There exist data, and now we have also measured it ourselves: Time to peak was 33 min and brain half-life was 56 min. Part of a preprint on drug-evoked dendritic Ca2+ signals: www.biorxiv.org/content/10.6...

1/3 🤔 Did you know an existing Olympus BX51WI can be upgraded into a 2P microscope? ➡️ With @Sutter’s DF-Scope®, a familiar lab workhorse for electrophysiology, transmitted-light and epifluorescence workflows gains the key optics/electronics for #TwoPhotonMicroscopy.

Registration is now open for the Paris Circuit Dynamics Conference & Workshop 2026! Neuromodulation of Neuronal Circuits: From Behavior to Computation Paris Brain Institute 16–17 September 2026 Registration is free (but required): www.paris-circuits.eu

Paris Circuit Dynamics

This conference will bring together leading experts to discuss how neuromodulatory systems shape neuronal circuit dynamics, behavior, and computation. The program will focus on how neuromodulators suc...

paris-circuits.eu

We developed a new approach for mapping absolute membrane voltage, based on dynamic photocycle control in Voltron2. www.biorxiv.org/content/10.6... Here's my favorite example: human iPSC colonies break into electrical domains as they begin to differentiate.

Could Excel be conscious? We surveyed more than Jan 1 1900 people to find out.

It's been a year in the making but I am happy to announce our UNC Neurophysiology core facility is online. What do we do? Patch clamp (from almost anything), calcium imaging, ABR, EEG, and more! Ready to help labs, research institutes, and companies anywhere! Details: www.med.unc.edu/neurophyscore/

Do you still have trouble exporting raw FLIM data from @leicamicrosystems.bsky.social and analyzing them with #OpenSource software? Good news! A very clear, step-by-step protocol has just been published by Jason E. Lee's lab. bio-protocol.org/en/bpdetail?...

Ich glaube, das BMWE möchte, dass möglichst wenig Leute mit Interesse an Klimaschutz an dieser Umfrage teilnehmen: www.jetzt-mitmachen.de/necp/step

Are you at #FENS2026? Check out Selin Kenet's poster from her work with Thomas Misgeld on Wednesday morning: 🧠 Off-target complement-mediated oligodendrocyte injury in a mouse model of neuromyelitis optica 📌 PS03-08AM-020 🔖 Preprint here: www.biorxiv.org/content/10.6...

I made it to #FENS2026 in Barcelona and am looking forward to an week of catching up with people and the newest trends in neuroscience. I am happy to to chat a out all things multiphoton, including lasers, as well as woodworking and dinghy sailing. DM me or catch me at booth 145 to grab a coffee

We are excited to share our collaboration with @pheereynolds.bsky.social, Robert Hindges & team on retinal plasticity, now out in Neuron! This work shows how visual experience during early development changes the anatomical and functional properties of amacrine cells and ultimately behavior!

Early visual experience elicits cellular and functional plasticity in the retina and alters behavior

The understanding of experience-dependent plasticity in the vertebrate retina is largely incomplete. Reynolds et al. discovered that raising animals in differently patterned visual environments change...

cell.com

📢 #FENS2026 giveaway! We're distributing 8 R2 system starter kits - including one with our new metal holder- for FENS attendees! Apply here: forms.gle/QFnUVZthhcfR...

14 years ago I went to FENS Forum in Barcelona to attend my very first scientific conference; fast-forward and I'm super excited to present to you part of my fantastic neuroscience research team in Göttingen. Do come by to say Hi and see what we've been up to recently! #fens2026

Mark my words: wenn die Abschaffung der telefonischen Krankschreibung und die Attestpflicht ab dem ersten Tag so kommen, wird das auf jeden Fall zu mehr Krankentagen in Deutschland führen.

Whats going on @fens.org ? Please lift this restriction. This tool was of incredible value!!!

Nikolas Karalis@nikolaskaralis.bsky.social · 2mo ago

With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary

Really excited to share our new preprint. Here we use our holographic optogenetics to ask a key question about how neurons need to fire to drive movements. We find a bunch of interesting things about what does, and doesn't drive movements. Brief summary below www.biorxiv.org/content/10.6...

The Importance of Synchrony in the Neural Control of Movement

Throughout the mammalian cortex, populations of neurons must work together to enact behaviors. While population recordings in motor cortex have revealed many aspects of when neurons fire during behavi...

biorxiv.org

The hippocampus is a brain region which is involved in building cognitive maps of our environment. But how stable is the brain's internal map of space? In our new paper, we tested what happens when we stimulate key inputs to the hippocampus's place cells in CA1 doi.org/10.1016/j.pn... 1/5

Excited to share this preprint from @ianoldenburg.bsky.social . To evoke movement with holo stim, you need the right pattern at the right time! Interestingly, the preparatory state before spont motion is not the same as the state permissive for evoked motion. Dig in! www.biorxiv.org/content/10.6...

The Importance of Synchrony in the Neural Control of Movement

Throughout the mammalian cortex, populations of neurons must work together to enact behaviors. While population recordings in motor cortex have revealed many aspects of when neurons fire during behavi...

biorxiv.org

Germany Weather records since 1881 1881-2000, 1 day with 40c One day in 119 years. 2000-2025, 9 days with 40c + 9 days in 25 years. 2026 4 days already 4 days in one week. #ClimateCrisis #Metacrisis

Ich habe die Seite www.awekas.at entdeckt, die zahlreiche private Wetterstationen beinhaltet und kartiert. Die Unterschiede zwischen DWD auf der grünen Wiese und dem privaten in den Städten sind insbesondere nachts und morgens krass: 6 Grad im kleinen Rottweil, je 4 in Stuttgart und Freiburg.

Johannes Waldschütz@jwfr.bsky.social · 2mo ago

Was mir an Hitzetagen immer wieder aufällt. Die gemeldeten Temperaturen stammen von den eher kühlen, im Grünen gelegen Stellen in den jeweiligen Städten und nicht aus den urbanen, dicht besiedelten und geteerten Zentren. Die Wetterdienste sollten künftig beides erfassen – es macht einen Unterschied!