This looks pretty cool:

Tobias Rausch@trausch.bsky.social · 3w ago

Wally, our command-line genome alignment plotter, is now available as a client-only web app: no install, no upload, runs entirely in your browser: www.gear-genomics.com/wally/

Yes - he CAN! (Sorry, we had to).

On 6 July 2026 Oxfordshire County Council will repair the lower part of the old stone wall in the alleyway alongside the Mason's Arms in Quarry, but the upper part of the stone wall will be replaced with a metal fence. See this Facebook post plus informative comment www.facebook.com/FriendsofQua...

Yesterday we attended the launch of the Women in Research Charter with the Secretary of State for Science, Technology and Innovation, Liz Kendall - along with some of our Fellows. See the Trust being included in the Charter’s “Best Practice pack” - www.gov.uk/government/p...

We are looking for a Junior Group Leader in Early Cancer Detection: an innovative scientist ready to build an independent research group and bring new ideas to one of our key research themes. Apply: www.nki.nl/news-events/... #tenure #vacancy #juniorPI #faculty #NKI

Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!

Replication-stress-induced chromatin loops protect fork stability - Nature

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

nature.com

Congratulations to Prof Richard Durbin, winner of the 2026 Genetics Society Medal! His pioneering work in computational genomics has transformed how we analyse and understand genome sequences.

Faster samtools sort, why aren't you using it? github.com/fg-labs/mako

GitHub - fg-labs/mako: Fast SAM/BAM sorter.

Fast SAM/BAM sorter. Contribute to fg-labs/mako development by creating an account on GitHub.

github.com

Scientists ejected from diabetes conference for distributing journal reprints Those ousted included ADA journal editor-in-chief Steven Kahn and former ADA president Desmond Schatz arstechnica.com/science/2026...

Scientists ejected from diabetes conference for distributing journal reprints

Those ousted included ADA journal editor-in-chief Steven Kahn and former ADA president Desmond Schatz...

arstechnica.com

We need to make sure this editorial goes viral Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now! diabetesjournals.org/care/article...

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Is it just me, or did @anthropic.com crank up the sycophancy levels again in Opus 4.8? I'm getting a lot of "great idea" and "very good point" comments since moving from 4.7 🤔

This is really exciting - and more evidence for Rust taking over bioinformatics.

Rammap: github.com/jwanglab/ram... Minimap2 v2.31: github.com/lh3/minimap2...

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

Cool new paper from Singapore's Gastric cancer consortium. They show that intestinal metaplasia in the stomach invariably features SBS17, just like Barrett's esophagus. They also confirm our findings from 2018 that SBS17 is strongly DNA-replication asymmetrical, but still no answer to what causes it

Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!

Exceptional scientists elected as Fellows of the Royal Society | Royal Society

Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.

royalsociety.org

I know Sean from when I worked on PFAM, then met him again many times at HHMI's Janelia Farm campus. Seeing his group being destroyed like this is devastating - he's a titan of bioinformatics, his contributions have been transformational for genomics and proteomics. Utter madness!

Prasad Jallepalli, MD, PhD@prasad.bsky.social · 3mo ago

In 2025, Sean Eddy received a letter from the National Institutes of Health, informing him that his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," he recalls. “Pearls before swine” was made for this

Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...

Patrick Vallance has twice written to MPs saying the budget for curiosity-driven research “will grow as the economy grows” But UKRI has flat cash for curiosity-led research through to 2030 When @isaacbarbosa1.bsky.social asked DSIT where the growth would come from, they had no answer A mystery

Research Professional News@resprofnews.bsky.social · 3mo ago

Dsit unable to explain Vallance claim on curiosity-led growth. www.researchprofessionalnews.com/rr-news-uk-p...

@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.

Incredible work. Will be going straight in my final year lectures as an example of how to combine genome-wide data with modelling to answer mechanistic hypotheses.

Elphege Nora Lab at UCSF@elphegenoralab.bsky.social · 3mo ago

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Extremely cool stuff coming from the team here: re-implementing htslib from scratch, with a focus on performance, compile-time checks and easier API #bioinformatics #ngs

Pascal@killercup.de · 3mo ago

Second post about Seqair, my #rustlang take on htslib. This one is about streaming VCF/BCF writing and type-state/session type APIs! #bioinformatics

For the most read-data heavy path in perbase, seqair is ~1.5x faster, which is awesome! I need to explore with some more datasets, but that's a pretty awesome win right off the bat.

Oxford City Council is to mark Europe Day today, by flying the European flag. Louise Upton, Lord Mayor of Oxford, fresh from her visit to twin town Leiden's Liberation Day celebration, (and re-election on Thursday), is hosting a European Reception in her Parlour at Oxford Town Hall.

When viruses hijack our cells, they give our cells instructions on how to make their proteins. The current flu vax uses viruses grown in eggs, which make proteins a bit differently than we do. We usually need to defend against flu viruses that were made in human cells. mRNA vax=partial instructions!

NBC News@nbcnews.com · 3mo ago

New results published in the New England Journal of Medicine finds Moderna’s mRNA flu vaccine gave more protection against illness than the standard flu shot in a Phase 3 clinical trial.

Some cool news from the lab: Pascal just built a faster, more memory efficient htslib in pure Rust that passes the same test suite used for htslib itself! Give how fundamental htslib is to NGS applications, this could be hugely impactful. We'd love to get feedback and contributions! #rust #bioinf

Pascal@killercup.de · 3mo ago

I spent some time writing about a #rust library I've been working on: seqair, an alternative to (a subset of) htslib. This is a big one! So much potential API surface to cover and I better have a good reason for it! deterministic.space/seqair.html

I came here in 1975. I'm a Nobel Prize-winning scientist born in Germany during WWII, came here in 1975 thinking there was no way fascism could take hold in this country. I was wrong. I don't not want to be book-ended by two fascist regimes. We will stand up and set things right.

Kristian G. Andersen@kgandersen.bsky.social · 4mo ago

Choice words from Dr. Szostak here. And while I am no Nobel Prize-winning scientist, I identify with the same quandary as an immigrant, moving here in 2009 and (proudly) becoming a citizen in 2023. I, too, don't recognize that country anymore 😢🇺🇸🧳🛫. newsletter.ofthebrave.org/p/im-a-nobel...

This is a really important issue - pubmed and other websites distort authorship contributions by only using the first/last author instead of honouring the "equal contributions" designation. This has real-life impact and disincentivises team science:

Wenying Shou@shougroup.bsky.social · 4mo ago

What began as a serious leisure activity in authorship justice has now been published by @plosbiology.org. Preserve equal contribution authorship designation during article indexing! www.linkedin.com/posts/wenyin...