Fantastic to finally see this out. It's already been incredibly useful for us and I'm sure will continue to be in the future!

Alex Holehouse@alexholehouse.bsky.social · last wk.

Huge congrats to the many authors who over MANY years worked on this (but especially @karaehunt.bsky.social , @trevorbrandt.bsky.social, Karina, @shaharsu.bsky.social and @remenecker.bsky.social. www.nature.com/articles/s41...

The Diamond Light Source is one of the UK's most productive scientific faclities. Just signed an open letter urging the STFC to ensure decisions about its future are "transparent, evidence-led, and made in meaningful consultation with its […] user communities." openletter.earth/open-letter-...

Very cool story, and potentially more nice evidence for link between #RNA transcript length and #condensate-depend #transcription regulation from CREs

Anders Sejr Hansen@andersshansen.bsky.social · 2w ago

Masahiro and I were fortunate to contribute some RCMC analyses to this beautiful paper from Koska and Wysocka that comprehensively dissects the determinants of promoter competition: www.nature.com/articles/s41...

Super work from @dozenoaks.bsky.social lab to help standardise #smFRET studies between in vitro and in cell models. 📏🔬🎇

Cell Biology J-Club@cellclub.bsky.social · 2w ago

A Universal Protein Ladder for Standardization of Diverse FRET Assays - Smith - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

We built a free tool to check your bibliography before you submit your manuscript for publication. Along the way, we ran experiments to understand what actually causes AI to hallucinate citations, and which references are most at risk.

A new tool to fight hallucinations in preprints - Paperpile

A blog about scientific publishing and academic productivity

paperpile.com

A Universal Protein Ladder for Standardization of Diverse FRET Assays - Smith - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

Ah, what a great resource!

Andreas Gschwind@argschwind.bsky.social · 3w ago

Thrilled to share that our ENCODE enhancer–gene mapping paper is now out in Nature! An encyclopedia of human enhancer–gene regulatory interactions: www.nature.com/articles/s41... Thread 👇 1/

For all you #Neuro people out there, there's still time to sign up for #NeuroBioUK! One of the friendliest and best value meetings happening anywhere. It's a must for anyone interested in the fundamentals of how #neurons work. 🧠

Ali Twelvetrees @dozenoaks.bsky.social · 4w ago

🚨 Early bird registration deadline for NeuroBioUK26 is fast approaching! Register by July 17th to secure your discounted rate (£35) AND remember to submit your abstract to be in the running for a talk slot. You're faithful organising committee have some hard deadlines this year, so please submit!

Very interesting new preprint from @jengreitz.bsky.social lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness. If promoters are responsive, they respond to all enhancers. www.biorxiv.org/content/10.6...

Really elegant work showing the importance of transient enhancer/promoter contacts. Also highlights why sometimes, building a tightly controlled model system in cells gives us the best way to get a clear answer to a complex question

Anders Sejr Hansen@andersshansen.bsky.social · last mo.

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Fun to see star grad student Owen Godwin present at today's single molecule SM@SH meeting!! Take homes: if you want to get nice streptavidin grids for enriching RNA on your grids, get your talc from Waitrose! @sheffielduni.bsky.social #cryoEM #eRNA

Here's a really exciting #phd opportunity to work with us on non-coding #RNAs in Bladder Cancer as part of a collaboration with Dr Jon Griffin and @iansudbery.bsky.social -check it out! tinyurl.com/4rp9abxr

Developing a non-coding RNA predictive biomarker in bladder cancer at University of Sheffield on FindAPhD.com

PhD Project - Developing a non-coding RNA predictive biomarker in bladder cancer at University of Sheffield, listed on FindAPhD.com

tinyurl.com

Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....

Congrats! This is very cool!

Matthew Taliaferro@jmtali.bsky.social · 2mo ago

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

Lots of coffee being drunk and vendor goodies being snapped up ahead of today's @mcb-sheffield.bsky.social research day- excited to hear about all our exciting projects! 🧫🧬🐁🔬

New preprint from our lab! We've been working out how the CMG replicative helicase gets built. 🧵 1/3

Guess what neurobiology fans?!? Registration is open!! More info on the website neurobiouk.sites.sheffield.ac.uk/registration #neurobiology #neurobiouk #neuronalcellbiology #molecularneurobiology #cellularneuroscience #neuroscience

NeuroBioUK - Registration

Step 1: Register through our event page. All attendees should register to attend through our event page. Early bird registration deadline is the 17th of July (£35) and late registration deadline is th...

neurobiouk.sites.sheffield.ac.uk

Ali Twelvetrees @dozenoaks.bsky.social · 5mo ago

Save the date for #NeuroBioUK26 Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date. neurobiouk.sites.sheffield.ac.uk

Really enjoyed this review on co-translational folding

Mathieu M.J.E. Rebeaud@chercheurjuteux.com · 3mo ago

The twisted tale of cotranslational protein complex assembly My friend Saurav wrote this with Ayala Shiber and this is a great review. www.sciencedirect.com/science/arti...

Really excited to meet @kellythd-nguyen.bsky.social in @sheffielduni.bsky.social today for the SM&SH #singlemolecules seminar.

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Nice structural work highlighting mechanisms of #RNA binding in the absence of sequence or structural conservation.

Nature Structural & Molecular Biology@natsmb.nature.com · 3mo ago

New online: Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...

#IDRs play critical roles shaping how #CBP and #p300 regulate #transcription and #chromatin. Despite many years of study, new behaviours continue to emerge. In her new Review, grad student Grace Gilbert takes a look at where the field is 👀: tinyurl.com/cbpidrs @biochemsoc.bsky.social

Only few days left to submit an abstract for our second annual QMUL centre for epigenetics meeting in June in London! Deadline 3rd may! Details below

QMUL Centre for Epigenetics @qmulepigenetics.bsky.social · 5mo ago

We're excited to announced that our 2nd Annual QMUL Centre for Epigenetics Conference is happening on June 18th, 2026 at Mile End! To find out more and book your ticket, please follow this link: www.qmul.ac.uk/epigenetics/... The deadline to book your tickets is Monday, June 8th 2026.

We've thought really hard about using #NMR to look at #RNA dynamics at our RNA-binding interfaces but always figured it was too hard for our system. Really exciting to see the possibility moving a step closer! Super work, congratulations!! #RBPs #IDRs #RNAstructure

Woodson Lab@woodsonlab.bsky.social · 4mo ago

Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...

Distribution and p300/CBP dependency of cis-regulatory elements are encoded by unique combinations of histone lactylation and acetylation https://www.biorxiv.org/content/10.64898/2026.04.14.718598v1

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab colab.research.google.com/github/KULL-...

Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · 8mo ago

We (@sobuelow.bsky.social & @kejohansson.bsky.social) tested AF-CALVADOS using the recently described PeptoneBench SAXS benchmark that contains SAXS data for >400 proteins with different amounts of order and disorder. The results look pretty good 😇 so we are sharing here while updating the preprint📝

Join us THIS Friday (10th April, 1 pm BST) for our UK Biomolecular Condensate seminar!! 👇👇

Janet Kumita@jrkumita.bsky.social · 4mo ago

Come join us for the next monthly on-line seminar (10th April, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (all are welcome to come and listen). Kellie Dean and Naoto Hori are presenting! @physicsoflifeuk.bsky.social