How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...

Read the paper featured on the cover of this month’s Cancer Discovery: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by @theaacr.bsky.social NextGen Star Daniel Azorín @danielazorin.bsky.social

#IRBBarcelona launches Spain’s 1st fully integrated Spatial #Omics Platform to bring cutting-edge spatial transcriptomics & proteomics & advanced image analysis & bioinformatics,connecting 5 Core Facilities into a unique end-to-end workflow for research & innovation. 🔗 https://shorturl.at/Z8Zho 🧪

The February issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by @danielazorin.bsky.social, Dirk Hoffmann, Sophie Heuer, Frank Winkler, et al. on targeting tumor microtubes to disrupt GBM cell networks. Read that & more: aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy. Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

Winkler Laboratory@winklerlab.bsky.social · 10mo ago

How to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...

#Glioblastoma cells don’t just grow — they extend tumor microtubes that let them invade the brain 🧠 and link into multicellular networks that resist therapy ☢️. We developed a strategy to inhibit these TMs — and make these cells vulnerable to therapy ☠️. This study is now online @Cancer Discovery

Winkler Laboratory@winklerlab.bsky.social · 10mo ago

How to disconnect therapy-resistant tumor networks in glioblastoma? In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy. doi.org/10.1158/2159...

📢New Article now published at Nature Cancer! 'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth' ✏️By Tian-Ming Gao, Jian-Ming Li and colleagues 🔗 www.nature.com/articles/s43...

Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth - Nature Cancer

Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.

nature.com

We are proud to present a Special Issue on Cancer Neuroscience, curated by editors Bennie Babayan & Ted Dobie. This issue offers a snapshot of the field through a collection of Perspectives, Reviews, and NeuroViews: cell.com/neuron/issue.... See below for details on the pieces:

Molecular recording of cellular protein kinase activity with chemical labeling: www.nature.com/articles/s41... Congratulations to De-en Sun and the entire team.

Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

nature.com

Need a distraction to shift your TMEntality today? If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews

Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...

link.springer.com

The EACR Cancer Neuroscience conference 14-16 October 2025 is open for registrations. Please bear in mind that the abstract deadline is June 30th 2025. We will be selecting a number of short talks from the abstracts! eacr.org/conference/c...

and the News & Views: www.nature.com/articles/d41...

Pinpointing neurons that hinder cancer treatment

Method to identify neurons associated with pancreatic cancer.

nature.com

I am happy to share our PDAC study, led by @verat-h.bsky.social. I developed a machine-learning pipeline to analyze large 3D light sheet microscopy volumes. We uncover how pancreatic cancer rewires neurons, advancing the field of Cancer Neuroscience. Full text here: www.nature.com/articles/s41...

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature. We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social www.nature.com/articles/s41...

Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies | Cancer Discovery | American Association for Cancer Research #paper aacrjournals.org/cancerdiscov...

Cancer Neuroscience of Brain Tumors: From Multicellular Networks to Neuroscience-Instructed Cancer Therapies

Abstract. Deepening our understanding of neuro-cancer interactions can innovate brain tumor treatment. This mini review unfolds the most relevant and recent insights into the neural mechanisms contrib...

aacrjournals.org

So many nice starter packs.. I couldn't find one related to spatial biology yet, so I started one 🧬🔬! Here's who I’ve included so far—let me know if you'd like to be added or suggest other must-follow accounts! #SpatialBiology go.bsky.app/SU34ELC