Latest work from the lab led by Sunandini Chandra! We dive into the world of nuclear pore complex plasticity and emerge with a new understanding of how the O-GlcNAc modification of nucleoporins responds to mechanical cues and sets the stringency of the NPC diffusion barrier in different cell types.
Mechanoresponsive modulation of nuclear pore complex structure and function by O-GlcNAc https://www.biorxiv.org/content/10.64898/2026.07.07.737034v1