#EESMicrotubules brought together an amazing community of microtubule researchers last week 🥼 Thank you to our wonderful participants, speakers, and organisers for 4 days of outstanding science and thought-provoking discussions! We hope to see you again at the next edition.
In situ structural biology: bridging molecular mechanisms with system-wide approaches www.embl.org/about/info/c...
In situ structural biology: bridging molecular mechanisms with system-wide approaches
embl.org
More throughput. More particles. More structures. On a JEOL CRYO ARM 300 II, Apollo sustained 1,820 movies/hour across a complete cryo-EM dataset—collecting over 500,000 particles and reconstructing apoferritin to 1.72 Å in a single afternoon. Read how: https://ow.ly/kEYn50ZjOFX
HIGH-THROUGHPUT CRYO-EM WITH APOLLO - Direct Electron
Up to 2,904 movies per hour and sustained 1,820 movies per hour, reconstructing apoferritin at 1.72 Å in a single afternoon.
ow.ly
I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️
Well done. But is GTP-tubulin in an expanded state at the tip of growing microtubules? Indeed, nobody knows 🤔
Wieczorek Lab@mike-wieczorek.bsky.social · last mo.New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863
La #plateforme TEM2C de l'UAR Biosit propose ses services en cryo-microscopie électronique, cryo-tomographie et cryo-CLEM pour la biologie structurale et cellulaire ➡️ www.ibisa.net/plateformes-... @cnrsbiologie.bsky.social @inserm.fr @rennesuniv.bsky.social
Transmission electron microscopy, cryo and CLEM (TEM2C)
Approches intégrées de cryo-microscopie électronique, cryo-tomographie et cryo-CLEM pour la biologie structurale et cellulaire.
ibisa.net
The new release of #BigVolumeBrowser (0.1.0) finally adds animation render functionality to it, plus some other navigation improvements and bug fixes. Here is a movie I've made for the microtubule network (via ExM) in different cell types. Contact me if you want it for educational/research purposes.
Looks cool, will try!
Allegretti Lab@matteoall.bsky.social · 2mo agoWe're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplo...
Check the little video they made from the interview (with the “Rolex” Rave skateboards tee-shirt 😆)
Christophe 🔬 Leterrier@christlet.bsky.social · 3mo agoI was interviewed by @snehakhedkar.bsky.social for The Scientist about our work using super-resolution microscopy to map the neuronal architecture, and make nice pictures along the way! Check the article here: www.the-scientist.com/super-resolu...
We are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...
Great discovery from Manuel Thery, even the Musée d'Orsay has a cytoskeleton 😍
Manuel Thery@manuelthery.bsky.social · 8mo ago#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January.
How do #tubulin dimers assemble and disassemble to form the #microtubule #cytoskeleton? Our recent #cryo-EM structures, published in #ScienceAdvances, demonstrate the processes of tubulin biogenesis and degradation. Click on the video and link below to learn more! www.science.org/doi/10.1126/...
You loved the A- and B-type lattices in microtubules? Discover the C- and D-types specific to the GTP-like state of tubulin during the talk of Matthieu Benoit, 8th May, 10:30 warwick.ac.uk/fac/sci/med/... #microtubule #tubulin #CryoEM
Motors and Filaments
Mechanochemistry of molecular motors and cytoskeletal filaments - a scientific meeting at the University of Warwick
warwick.ac.uk
The full EMBO microtubule program is now online 🤩 Note the talk of Celine Callens from our lab presenting the discovery and structural characterization of internal proteins within Xenopus spermatid microtubules on Thursday, 10:40 😍 www.embl.org/about/info/c... #microtubule #CryoEM
Microtubules: from atoms to complex systems
embl.org
Ready for #CellLaVie2026? Program & registration are live! Join us Oct 21–23, 2026 at Institut Pasteur, Paris, for multidisciplinary cell biology, imaging, talks, posters & outreach, w/ Manuel Théry's behind-the-scenes look at the Musée d’Orsay video-mapping project. www.atoutcom.com/cell-la-vie/
Barely a week to go until our "Motors and Filaments" meeting. Programme is ready. Catering ordered. My 3d printer has been busy too: have a look into the mingle bingo and dinner quiz prizes box. tinyurl.com/mechanochemi...
#ESR Faudra-t-il en arriver là pour financer la recherche ? youtu.be/x2XMfjfG2ug?...
ICM - Le strip-tease
YouTube video by Publicis Conseil
youtu.be
Vaults are still among the most mysterious of all structures found in eukaryotes. This is extremely cool and unexpected.
Katharina Geißler@kgeissler.bsky.social · 4mo agoOut now in Nature Communications! We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky www.nature.com/articles/s41...
A powerful electrical motor propels bacteria in virtually every gut and puddle on Earth. After 50 years, it has finally been understood. @nattyover.bsky.social reports: www.quantamagazine.org/what-physica...
What Physical ‘Life Force’ Turns Biology’s Wheels? | Quanta Magazine
The bacterial flagellar motor is finally understood after 50 years. In its workings, columnist Natalie Wolchover finds the essence of life.
quantamagazine.org
Stunning 😍, congrats!!!
Ben Engel@cellarchlab.com · 4mo agoAcross scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel
Beautiful work 😍
Shweta Nandakumar@bucklingmt.bsky.social · 11mo agoDespite their high rigidity, microtubules (MTs) dynamically bend and buckle in cells. MT-self repair is inherent to their metastable nature, but it remains unclear whether just inherent repair mechanisms are sufficient to maintain MT integrity🧵 (1/9) www.biorxiv.org/content/10.1...
A very nice study showing that there is no obvious relationship between tubulin compaction/expansion state and its nucleotide state. Indeed, there is no experimental data demonstrating that GTP-tubulin is expanded in the GTP-cap at microtubule growing ends.
cryoEM papers@cryoempapers.bsky.social · 4mo agoMicrotubules in the axon are GDP bound but adopt a stable GTP-like expanded state pubmed.ncbi.nlm.nih.gov/41951886/ #cryoEM
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Opening of our JEOL Cryo-ARM 200, 2 April 2026 :-) Don't hesitate to get in touch with us if you want nice cryo-EM and/or cryo-ET data ! biosit.univ-rennes.fr/en/tem2c #cryo-EM #microtubule
New paper in Nature Communications: we identified ANTXR2 (CMG2) as the cellular receptor for C. perfringens NetF toxin, causing hemorrhagic enteritis in dogs and foals. ANTXR2 was previously known as the receptor for anthrax toxin PA. doi.org/10.1038/s414...
Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor - Nature Communications
This study identifies ANTXR2 as the cellular receptor for Clostridium perfringens toxin NetF and determines its structure bound to the toxin using cryo-EM, revealing a distinct lateral binding mechani...
doi.org
