We also released the OST-Sting-flox mouse strain, originally developed by Bernard Malissen. It combines an N-terminal Strep-tagged STING allele with a floxed cassette and is now available through The Jackson Laboratory. www.jax.org/strain/041165

Shout out to say that our GFP-cGAS knock-in mouse is now available through the MMRRC. This strain is particularly useful for investigating nucleic acids associated with cGAS. www.mmrrc.org/catalog/sds....

🚨Novel Concepts in #Innate_Immunity #conference (NCII) 18-20 May 2027 speaker list is out: 🚨 Join us @uni_tue to hear @audeber.bsky.social, @drusqui.bsky.social @soyonhonglab.bsky.social, @laemmermann-lab.bsky.social, @manellab.bsky.social, @v-hornung.bsky.social and many others! Link👇

#EMBOsignaling2026 last day already! Full house for a terrific panel session with editors @science.org @cp-immunity.bsky.social @jem.org @cp-cellreports.bsky.social @embopress.org @plosbiology.org @cp-trendsimmuno.bsky.social @cp-cellhostmicrobe.bsky.social Science Signaling

#EMBOsignaling2026 First Keynote by Mihai Netea on trained immunity! The level of science was inversely proportional to the size of the screen! Moving to the proper Naturalis auditorium for the workshop tomorrow. Stay tuned!

@embo.org #EMBOsignaling2026 welcoming the participants now!

Few more seats released for the upcoming #EMBO workshop #Pathogen #Immunity and #Signaling in Leiden, Netherlands, 8-12 June. Awesome meeting, great crowd, reasonable price, terrific venue. Only good reasons to join! meetings.embo.org/event/26-pat...

🧬🇯🇵 Registrations are now open for the 2026 Nucleic Acid Immunity Meeting in Nara, Japan. Fantastic line‑up of invited speakers already. www.ifrec.osaka-u.ac.jp/nais26/index...

Excited to participate in the event and share our ongoing work in this space. Join!

Institut Pasteur | 130 years of biomedical research@pasteur.fr · 6mo ago

Women’s health, Women in Health 🚺 📅 March 17th 2026 📍Institut Pasteur, Paris, France Registration and Poster application ↘️ research.pasteur.fr/fr/event/wom...

⚠️ One week left to submit your abstract to the 2026 @embo.org Workshop on #Pathogen #Immunity and #Signaling. 👇

Nicolas Manel Lab@manellab.bsky.social · 10mo ago

🔥 Mark the date! 🗓️ Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived. Terrific roster of speakers, many spots for talks, spectacular venue in Leiden. Submit your abstract. Join us on 8 – 11 June 2026. meetings.embo.org/event/26-pat...

🌈 Glory to the international labs. This is our new weekly routine. 👇

The concept of antagonisitic pleiotropy in aging (well established for senescence) revisited for the case of infectious diseases. 👇

Nature@nature.com · 7mo ago

How does ageing influence the way our bodies handle infection? go.nature.com/4sMZuqW

@globalimmuno.bsky.social replay here: www.youtube.com/watch?v=mFr4... Enjoy. Thanks to the wonderful team for making this happen.

"Centromeres reimagined in the immune system" by Dr. Nicolas Manel

YouTube video by GLOBAL IMMUNOTALKS

youtube.com

Not to be missed! Our next #globalimmuno talk, today Wednesday, November 26th at 9am PST, noon EST, 5pm GMT by Dr. Nicolas Manel. Title: “Centromeres reimagined in the immune system” ZOOM LINK: us06web.zoom.us/webinar/regi... LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...

Welcome! You are invited to join a webinar: GLOBAL IMMUNOTALKS: Virtual immunology seminar series . After registering, you will receive a confirmation email about joining the webinar.

Subscribe to our YouTube channel to stay updated and participate in the discussions: https://www.youtube.com/c/GLOBALIMMUNOTALKS We now offer: ✅ Live streaming on YouTube (in addition to Zoom) ✅ Asyn...

us06web.zoom.us

🔥In two days!

Global Immunotalks@globalimmuno.bsky.social · 8mo ago

Looking forward to our next #globalimmuno talk this Wednesday, November 26th, at 9am PST, noon EST, 5pm GMT by Dr. Nicolas Manel. Title: “Centromeres reimagined in the immune system” ZOOM LINK: us06web.zoom.us/webinar/regi... LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUNOTALKS

You bet. Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!

@dfachinetti.bsky.social · 9mo ago

Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!

🔥👇 The place to be.

@dfachinetti.bsky.social · 9mo ago

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

🔥 Mark the date! 🗓️ Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived. Terrific roster of speakers, many spots for talks, spectacular venue in Leiden. Submit your abstract. Join us on 8 – 11 June 2026. meetings.embo.org/event/26-pat...

Pathogen Immunity and Signalling

Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

meetings.embo.org

Fantastic seminar today by Norbert Pardi from @upenn.edu who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules. mRNA nanoparticules are the therapeutics of tomorrow!

🔥Really cool work by our neighbors @dfachinetti.bsky.social together with Stanford's only @naltemose.bsky.social showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.

@dfachinetti.bsky.social · 11mo ago

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens. 🙏 to the authors www.cell.com/molecular-ce...

DIY innate immune sensing: Crafting fresh DNA to detect viruses

The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In a recent Cell publication, Lahaye et al. discovered that viral infection triggers de novo synthesis of self-DNA-activa...

cell.com

Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social See you all on November 26th! Thanks so much to the organisers for putting this together.

Global Immunotalks@globalimmuno.bsky.social · last yr.

🧬2nd Semester 2025 lineup is here! Join us for a new round of cutting-edge immunology seminars from top researchers around the world! Mark your calendar & share! For more info: linktr.ee/globalimmuno...

Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage. Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.

Esashi Lab@esashilab.bsky.social · last yr.

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

Centromeres as minefields: host–virus warfare

Cell Research - Centromeres as minefields: host–virus warfare

rdcu.be

Nicolas Manel Lab@manellab.bsky.social · last yr.

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic... Thanks @addgene.bsky.social for making this possible!

Nicolas Manel Lab@manellab.bsky.social · last yr.

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Trans...genes! Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

cell.com

📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

How does a cell detect infection by a DNA virus in its nucleus?