We are looking for a postdoc to investigate the principles of cellular organization using state-of-the-art microscopy! Please repost to help us find a colleague :) Full details here bio.rptu.de/fileadmin/ag...

Really excited to see the square-aperture tiles turned into very large tomograms! github.com/hamid13r/sqa...

cryoEM papers@cryoempapers.bsky.social · last wk.

Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging www.biorxiv.org/content/10.64898/2026.08.27.747605v1 #cryoEM

Congratulations Kelly. Well deserved!

Kelly Nguyen@kellythd-nguyen.bsky.social · 2w ago

Such an honor to receive the Francis Crick Medal from the Royal Society. As I always say, I am just very lucky to have worked with amazing people. Big shoutout to all past and present lab members, mentors, colleagues and collaborators for continuing inspiring me!

Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...

🔄 Mixing Two Cryo-EM Datasets on Purpose: A Cryo-EM Heterogeneity Challenge What happens when you deliberately mix two #cryo-EM datasets containing different conformational states? Our latest #CryoSPARC blog distills the practical lessons from the accompanying FaNaC1 case study 👉 bit.ly/3ScIZa3

Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...

Great to see this finally published! We describe channels at the poxvirus core wall involved in nucleic acid release. www.nature.com/articles/s41...

In situ structure of the poxvirus portal complex - Nature

Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as a...

nature.com

One cell, one tomogram! Our montage tomography workflow, MOSAIC, is out in Structure, and MontageMaker is on GitHub! MOSAIC: www.cell.com/structure/fu... MontageMaker: github.com/MPI-Dortmund... Big thanks to @maikaboiero.bsky.social, Adriana Prajica, Gavin Rice, and @raunser-lab.bsky.social!

Huge congrats to @jbinovsky.bsky.social ! Impressive work on that massive structure (and visually appealing too).

Ján Bíňovský@jbinovsky.bsky.social · 2mo ago

🔥My first (co)first-author paper is out🔥 The surfaces of Gram+ and Gram- bacteria are markedly different from each other. How are phages equipped to breach the Gram+ envelope❓ 💡We report a baseplate structure uniquely adapted to infect Gram+ S. aureus. A 🧵⬇️ 1/8 #phagesky #cryoEM 🧪

The LocScale 2.0 and SURFER papers are now both published in final form. LocScale 2.0: www.nature.com/articles/s41... SURFER: onlinelibrary.wiley.com/iucr/doi/10.... Led by @alok-bharadwaj.bsky.social with contributions of former MSc/Bsc students Reinier de Bruin and Lotte Veerbeek.

1/5: Our latest preprint is out! We show that LEA proteins can diversify particle orientations in cryo-EM, helping to overcome preferred orientation at the air-water interface (AWI). www.biorxiv.org/cgi/content/... with @cijilim.bsky.social and Tim Grant #CryoEM #LEAproteins

Diversifying particle-orientation distributions in cryo-EM with LEA protein additives

Preferential orientation at the air-water interface (AWI) remains a persistent challenge in cryo-electron microscopy, often requiring extensive optimization or specialized grid preparation strategies....

biorxiv.org

Opportunity for computational chemist at Genentech (South San Francisco CA USA) #CompChem #cheminformatics #AI #ML #ChemJobs #chemsky 🧪 careers.gene.com/us/en/job/20...

Principal Scientist (Computational Chemistry) in South San Francisco, California, United States of America | Research & Development at Genentech

Apply for Principal Scientist (Computational Chemistry) job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

careers.gene.com

research.pasteur.fr/en/call/mid-...

Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research

Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...

research.pasteur.fr

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs

How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.

New paper from the group! We were curious if the longevity of naked mole-rats has anything to do with their protein synthesis machinery. It was shown that the ribosomal 28S is split into 3 subunits Our cryo-EM study of the NMR ribosomes by @mehmetguel.bsky.social etal www.nature.com/articles/s41...

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA - Nature Communications

The long-living rodent naked mole-rat has a distinct break in its 28S ribosomal RNA. Here, the authors present cryo-EM structures showing this cleavage is stabilized by surrounding ribosomal proteins,...

nature.com

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚

The Chlamy chloroplast RNA polymerase paper is here!🤩 It's a beautiful and interesting structure, which raises some interesting questions about evolution. Congrats to @sramundo.bsky.social, @schullerjm.bsky.social, and all your rad peeps for getting this done 💪 #plantscience #cryoEM 🌾🔬🧪

Silvia Ramundo@sramundo.bsky.social · 3mo ago

1/7 New preprint: we found that Chlamydomonas carries a giant and unexpectedly elaborate chloroplast RNA polymerase with 12 previously unknown subunits, overturning the idea that the complexity of this organellar enzyme emerged during plant terrestrialization! www.biorxiv.org/content/10.6...

Meet SpudCell, a synthetic cell made from lifeless ingredients that feeds, grows, divides, and experiences selection. If it doesn't have all the hallmarks of life, it has a lot! Here's my story. Gift link: nyti.ms/4vCbTih

A deeper dive into the article we published last week in @nature.com. I will start with the framing and methodology as they are key to understanding the surprising results: Most proteomics experiments begin with an assumption. www.nature.com/articles/s41... 1/

Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...

Arc mediates intercellular tau transmission via extracellular vesicles

Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…

authors.elsevier.com

I am very proud to my student Stasia whose manuscript about the nucleocapsid assembly of an ephemerovirus is now available to read. Within three years she managed to defend her thesis, submit the manuscript and secure a postdoc job, while adapting to the UK weather! www.biorxiv.org/content/10.6...

Cryo-electron microscopy structure of the bovine ephemeral fever virus RNA-nucleoprotein assembly

Bovine ephemeral fever virus (BEFV), a member of the Rhabdoviridae family, is an arthropod-borne pathogen that causes acute febrile disease in cattle. The structural basis of its genome encapsidation ...

biorxiv.org

This is a thrilling and very surprising discovery, opening plenty of new research questions.

Nikolai Slavov@slavov-n.bsky.social · 3mo ago

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Our paper, “Deep learning reveals antimicrobial peptides within prions,” is now published in Nature Microbiology @natureportfolio.nature.com. We used AI to ask an unexpected question: could proteins best known for their role in fatal neurodegenerative diseases encode molecules that fight infection?

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Pulsed-electron illumination does not reduce beam damage for imaging biological macromolecules pubmed.ncbi.nlm.nih.gov/42309992/ #cryoEM