Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae. Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...

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We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social

#mSphere started a new article collections titled mSphere Legacy. These articles will be authored by our senior colleagues in the microbial sciences community to not only reflect back on their own careers and journey's but how they see the future unfolding. @asm.org journals.asm.org/eprint/PZEHP...

mSphere Legacy: Sharing wisdom at the culmination of a scientific career | mSphere

“We will be known forever by the tracks we leave.”

journals.asm.org

Using spIsoNet to address the preferred-orientation problem in cryoEM reconstructions pubmed.ncbi.nlm.nih.gov/42427643/ #cryoEM

New paper from the @xionglab.bsky.social and Mogessie labs at Yale! We uncover the molecular architecture of mammalian oocyte cytoplasmic lattices (CPLs), revealing GTP-bound tubulin associated with a degradative protein complex. Read the paper: doi.org/10.1038/s415...

Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs - Nature Structural & Molecular Biology

Li et al. obtain high-resolution, native structures revealing that cytoplasmic lattices in mammalian eggs organize and store degradative and cytoskeletal complexes for early embryonic development.

doi.org

Now online! Structural basis for host membrane binding and remodeling by invading malaria parasites

Structural basis for host membrane binding and remodeling by invading malaria parasites

Isolation and high-resolution structure of the moving junction protein complex from invading malaria parasites reveals an intricate molecular machine that bridges the host-pathogen interface and informs the de novo design of a small protein binder that inhibits parasite entry into host cells.

dlvr.it

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

#NatMicroPicks Hidden in plain sight! 💊🦠 Assessing overlooked minor compounds uncovered a new antibiotic, manikomycin, from well-studied Streptomyces species that kills bacteria by uniquely targeting the ribosomal E-site #MicroSky www.nature.com/articles/s41...

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...

nature.com

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Super proud of Juliette Uy (julietteuy.bsky.social) for her outstanding work on the Toxoplasma inner membrane complex!!! She is headed off to Johns Hopkins for her MD/PhD and is a rising star! Also cheers to Qing Lou for her terrific EM work for this paper! journals.plos.org/plospathogen...

Toxoplasma IMC1 is a central component of the subpellicular network and plays critical roles in parasite morphology, replication, and infectivity

Author summary Parasites in the phylum Apicomplexa maintain their intracellular lifestyle using specialized organelles that mediate the lytic cycle of host cell invasion, intracellular replication, an...

journals.plos.org

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Nanobodies against malaria parasite adhesins that block receptor engagement and invasion Lovely work by @jaisondsa.bsky.social and Jill Chmielewski on PfRh5, PfRh4 & PvRBP2b nanobodies + stabilized PfRh4 🦙🩸⛰️ Have a read, share widely and please give us feedback! www.biorxiv.org/content/10.6...

Excited to highlight some exciting findings from our recent paper that uncovers how an unusual molecular motor, Myosin F, powers actin dynamics in Toxoplasma gondii. journals.biologists.com/jcs/article/...

Molecular features of myosin F adapted for driving actin flows in Toxoplasma gondii

Highlighted Article: MyoF regulates actin organization in T. gondii by assembling into an oligomeric complex that contains multiple motor domains.

journals.biologists.com

Incredibly excited and grateful to be joining the Burroughs Wellcome Fund family! Thank you @bwfund.bsky.social and the selection committee members for supporting and believing in our vision and congrats to the other 2026 PATH Investigators!!! 🥳

Burroughs Wellcome Fund@bwfund.bsky.social · 3mo ago

BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/bwf-ann... #bwfpath

The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social

Architecture of clathrin-independent AP3:ARF1-coated carriers

AP3 generates clathrin-free carriers on endosomes by organizing via ARF1 dimers into elongated membrane-deforming arrays.

science.org

Absolutely extraordinary work from Hui Gao, John Briggs and co @mpibiochem.bsky.social on the structure of the influenza matrix protein in situ, particularly in filamentous virions. It's beautiful, and answers questions I've been wondering about for twenty years www.biorxiv.org/content/10.6...

Excited about parasites? Love watching movies? Come join our Wellcome-funded project! Parasitology friends, please do share far and wide.

@knuepferlab.bsky.social · 6mo ago

The HartLab is looking for a research assistant to support the exploration of red blood cell invasion by Plasmodium and Babesia parasites and the establishment of their distinct intracellular niches. For more information on this 4-year position follow the link below: www.jobs.ac.uk/job/DQH098/r...

Applications and prospects of cryo-electron tomography in drug discovery and understanding disease Review article by @camilaclemente.bsky.social in our lab www.sciencedirect.com/science/arti...

Applications and prospects of cryo-electron tomography in drug discovery and understanding disease

Cryo-electron tomography (cryo-ET) is emerging as a transformative tool for structural biology. Unlike methods based on purified molecules, cryo-ET en…

sciencedirect.com

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

EMBL@embl.org · 3mo ago

Despite its name, SNOR, a newly discovered protein, is hardly asleep on the job. EMBL researchers’ newest technologies allowed their scientific collaboration to discover a tiny protein with a big role in awakening cells from dormancy to restart protein synthesis. www.embl.org/news/science...

It's out! 🥳 In situ architecture of #plasmodesmata - plant cytoplasmic bridges - by #cryoET. 📝 Paper: www.nature.com/articles/s41... 🧵 Thread: bsky.app/profile/madi... #teamtomo #proteomics #AlphaFold

In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography - Nature Plants

Using cryo-electron tomography, the authors reveal how plasmodesmata (plant cytoplasmic bridges) are gated by cell wall remodelling and how helical protein assemblies scaffold internal membranes, with...

nature.com

Marcel Dickmanns | 🌿❄️🔬@madic.bsky.social · last yr.

New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...

Can enzymes be made to self-destruct for therapeutic purposes? “Reaction-hijacking of enzymes to generate potent therapeutic modulators in situ”. Very pleased that our Review is part of the 50th anniversary special edition of Trends in Biochemical Science. doi.org/10.1016/j.ti...

Was just asked to spread the word about this position. Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world! www.irbbarcelona.org/sites/defaul...

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Thrilled to share a new collaborative preprint, joint with Sean Prigge @johnshopkinssph.bsky.social, on the apicoplast ACP in #malaria parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @parasitesrule.org www.biorxiv.org/content/10.6...