I’m truly honored and deeply grateful to receive the Young Investigator Award from the SMI. Thanks to my mentors, collaborators, trainees, and everyone who has supported our work. I’m excited to continue exploring how the intestinal microbiome shapes mucosal immunity.

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

Journal of Experimental Medicine@jem.org · 11mo ago

LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/... #Microbiome

Myeloid IL-1β and stress exert opposing control over colitis severity through the α₁-adrenergic-enterochromaffin axis, uncovering a neuro-immune-epithelial circuit that shapes intestinal inflammation @cp-immunity.bsky.social www.cell.com/immunity/ful...

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

nature.com

Preview @cp-immunity.bsky.social Cutting the Gordian knot: Untangling gasdermin C from pyroptosis www.cell.com/immunity/ful... on www.cell.com/immunity/ful...

Tenure-track Assistant Professor position in Bioinformatics in the Department of Biology at the University of San Francisco usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...

Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco

Job Title: Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco Job Summary: The Department of Biology at the University of San Francisco invites applications for a fu...

usfca.wd5.myworkdayjobs.com

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

cell.com

The Global Grants for Gut Health are now open. If your research explores how nutrition affects the gut #microbiome or barrier function, you may be eligible to apply for one of three grants each offering up to USD$100K. Apply here: go.nature.com/4kb9cO1 #Academicsky 🍎📃

Welcome to #InnovationsSymposium2025! We’re excited to be together again—this year on the beautiful island of Oʻahu—to hear the latest #IBD research and encourage dialogue and connections that continue to move the work forward.

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

cell.com

The unintended consequences of a gut microbiome transplant www.cell.com/cell/abstrac...

Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and ...

cell.com

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis www.cell.com/cell-host-mi...

Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!

Journal of Experimental Medicine@jem.org · 2y ago

First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/... #InfectiousDisease

Stand Up for Science Rally in Pittsburgh

#KSHostMicrobe25 in beautiful Banff-such an awesome meeting. Was great to talk at the @keystonesymposia.bsky.social about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy #microbiota #immunometabolism #cancer

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports... Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...

cell.com