Arvind Varsani

@viralnomad.bsky.social

Nomadic 'viral' scientist #virome #virus #virus_evolution #virology 🇰🇪🇿🇦🇳🇿

Some bat alphacoronaviruses can exploit an entirely different receptor to enter human cells. This could lead to crossover events could be the first step in future epidemics, though we are not there yet and there would be many more barriers to overcome also. www.nature.com/articles/s41...

Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells - Nature

Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.

nature.com

Please share! My lab has an open fully-funded PhD position at Vilnius University's Life Sciences Center in Lithuania. The PhD project will involve identifying missing orthomyxovirus segments from public sequence data. Applicants must hold an MSc by June & have bioinformatics experience. 1/2

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AMP thought of as one-off in Drosophila may have moved around a lot…much like genes encoding antiparasitoid proteins fand pore-forming toxins in insects (see karger.com/jin/article/...). Extremely cool. A challenge is that short peptides present a very hard problem—discerning convergence from HGT…

Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila

Abstract. Introduction: Species of the ananassae subgroup of Drosophilidae are highly resistant to parasitoid wasp infections. We have previously shown that the genes encoding cytolethal distending to...

karger.com

Mark A. Hanson@hansonmark.bsky.social · 7mo ago

Pleased to finally share this fun collab that began at #Ento23 @cedricaumont.bsky.social presented & I had seen NCBI annotated some cockroach genomes as "contaminated." Turns out NCBI & I were wrong (much more fun). Horizontal transfer of an #AntimicrobialPeptide across insects bit.ly/DrsHGT 1/🧵

A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insects

Deltaviruses don’t just borrow a helper virus, they can travel inside it to infect news. A literal Trojan Horse “virus-in-a-virus”🤯@viroscope.bsky.social @karimaj.bsky.social www.cell.com/cell/fulltex... @cellcellpress.bsky.social

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Viroscope@viroscope.bsky.social · 7mo ago

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

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