🧬 New preprint: "Selection and surveillance of 5S ribosomal RNA genes in human populations." The 5S rRNA genes sit in a ~80-copy array on chromosome 1, one of the least-explored parts of the genome. We traced its variation from DNA to ribosome. 1/4🧵

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Excited to share that I’ll be presenting my work at #ESID2026 in Maastricht! 🇳🇱 You can join the conversation too. Submit your late-breaking research by 30 August & get published in JHI! 🧬 👉 invt.io/1bxbz93skkb #ESID2026 #InbornErrorsOfImmunity #Immunology #IEI

I will present my research at ESID 2026, join me

Register today and save!

invt.io

Very interesting paper on defect in RNA editing: rupress.org/jem/article-...

ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype

In this work, we identify a new type I IFN–dependent psoriasis subtype resulting from rare heterozygous variants in ADAR1 and associated with a specific re

rupress.org

Happy to see this story out! Congrats to Diana and everyone involved :)

Rockefeller University Press@rupress.org · 2mo ago

In @jem.org, Olguín Calderón et al. report four rare or common hypomorphic IL23R variants that, when present in the homozygous state, impair IFN-γ production by innate-like T and NK cells, thereby conferring a predisposition to #tuberculosis. rupress.org/jem/article/... @casanovalab.bsky.social

THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org

Wow! That's very bad! Great investigative work. @reeserichardson.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

Wow, cool! Adult onset autoimmunity can be genetic.

Journal of Human Immunity@jhumimmunity.org · 4mo ago

STING gain-of-function has primarily been described to cause pediatric-onset disease. Here, Riley, Kotzin, Finck, Miner et al. report a surprisingly high prevalence of adult-onset #SAVI among patients with common #autoimmune disease diagnoses. rupress.org/jhi/article/... #Autoimmunity #IEIs

Amazing work, contextualizing the mechanism of action of the widely used chemotherapeutic azacytidine. We are very happy to have contributed a little bit to this manuscript! Big congrats to Julian, Carla and everyone involved!

Gene Center Munich @LMU Munich@genecenter-lmu.bsky.social · 5mo ago

📣Publication alert: Julian Stingele and his team show that the chemotherapeutic drug azacitidine damages RNA and reveal a possible approach to improve therapies🤩👏 www.sciencedirect.com/science/arti... @jstingele.bsky.social @lmu.de @shubozhao.bsky.social

I am excited to receive this fellowship, which will help us with our research on regulated mRNA translation in the human immune system! www.daimler-benz-stiftung.de/cms/de/foerd...

I am very excited to share that our paper is on the cover of this month's JHI! rupress.org/jhi/issue/2/2

This is the first News & Views of @jhumimmunity.org and it is a must-read ! TLR7 mutations leading to enhanced TLR7 signaling in humans url: rupress.org/jhi/article/...

TLR7 mutations leading to enhanced TLR7 signaling in humans

Three studies in this issue of JHI extend our understanding of the genetic, molecular, and clinical characteristics of human disease associated with a gain

rupress.org

Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease. New study by Qinhua Zhou (Fudan University), Jacinta Bustamante @institutimagine.bsky.social, Jonathan Bohlen @jonathanbohlen.bsky.social @lmumuenchen.bsky.social & colleagues rupress.org/jhi/article/...

New paper in the Journal of Human Immunity! We report complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease -- four new families from Iran, Oman, China, and the USA. doi.org/10.70962/jhi...

Complete and partial forms of X-linked MCTS1 deficiency in patients with mycobacterial disease

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Four new patients carried three previously undescribed truncating or loss-of-expr

doi.org

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. In @jhumimmunity.org, Zhou et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

X-linked MCTS1 deficiency causes susceptibility to mycobacterial disease. Zhou, Bustamante, Bohlen et al. show that report 4 new patients carrying 3 previously undescribed truncating or loss-of-expression variants, presenting w/ BCG disease or M. abscessus infection. rupress.org/jhi/article/...

Our lab website is live! 🥳 We study how mRNA translation controls immune cell function and how defects in the protein synthesis machinery cause human disease. Come say hello and learn about what we do at the Gene Center Munich. bohlenlab.com

Active transport of tRNAs facilitates distributed protein synthesis https://www.biorxiv.org/content/10.64898/2026.01.26.698744v1

🙌 Herzlichen Glückwunsch! @jonathanbohlen.bsky.social und Jiamin Hou wurden von der @dfg.de im Rahmen des Emmy Noether-Programms ausgezeichnet. Die Fördersumme beträgt jeweils 1,85 Mio. Euro für einen Zeitraum von sechs Jahren. #LMUMuenchen #Astrophysik #Molekularbiologie www.lmu.de/de/newsroom/...

Emmy Noether-Förderung für zwei LMU-Forschende

Astrophysikerin Jiamin Hou und Molekularbiologe Jonathan Bohlen erhalten Förderungen aus dem Emmy Noether-Programm der DFG.

lmu.de

I don't want to be a huge stickler and I actually really like this paper, congrats to the authors for the nice work. But isn't the use of human eyes in the graphical abstract rather misleading for a paper that contains entirely mouse experiments?

γδ T cell Forum@forum-gd.bsky.social · 7mo ago

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity #gdTcells @cp-immunity.bsky.social

🥳 We are excited to share the first publication from the Bohlen Lab! "Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B but not T cell development and function" www.nature.com/articles/s41... together with the Tangye Lab and @bloodgenes.bsky.social and many more! 1/n

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function - Nature Immunology

Bohlen and colleagues report that the E3 ubiquitin ligase CBL is necessary for the development, tolerance and activation of B cells in humans, unlike in mice where CBL deficiency results in loss of T ...

nature.com

Honored to get this opportunity to build out my team and explore molecular immunology!

Gene Center Munich @LMU Munich@genecenter-lmu.bsky.social · 9mo ago

🥳🥂Huge congratulations to Jonathan Bohlen on being awarded an Emmy Noether Grant by @dfg.de 😊🤩 His project addresses a central open question in immunology: how mRNA translation governs the function of T cells. www.genzentrum.uni-muenchen.de/news-events/... @jonathanbohlen.bsky.social

📣Publication alert! A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇 www.lmu.de/en/newsroom/...

Colliding ribosomes signal cellular stress

LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.

lmu.de

How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4 rdcu.be/eRmJl #ribosome #cryoEM #LMU #JHMI

Whipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder: IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...

In less than 8 months, @jhumimmunity has published 56 papers (rupress.org/jhi), including 10 already on PubMed (pubmed.ncbi.nlm.nih.gov?term=j+hum+i...). Please submit studies of human inborn errors of immunity and their phenocopies (rupress.org/jhi/article-...) !

We report a 5'UTR variant in YEATS4 that confers resistance to tuberculosis through altering the translation of the YEATS4 open-reading frame! Congrats to Clement Conil and colleagues at @casanovalab.bsky.social! It was fun to help with this story! link.springer.com/article/10.1...

A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure - Genome Medicine

Background Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals—so-called resisters—have persistently negative results for the tuberculin skin test (TST) and interferon-gam...

link.springer.com

New in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/... #Staphylococcus #Ubiquitin

Huge variability documented in how publishers respond when informed about a problematic body of work by a research group. www.jclinepi.com/article/S089... #publishers #retractions

A MUST-READ Review on Penetrance of Human Monogenic Inborn Errors (of Immunity, or not): Incomplete penetrance in inborn errors of immunity: A skeleton in the closet—The sequel url: rupress.org/jhi/article/...