Kane Foster
@kanefos.bsky.social
I'm interested in the immune response to cancer. Postdoc at Dana-Farber Cancer Institute and Broad Institute, Boston USA. I also like sci-fi literature & electronic dance music. he/him
Horrific story of a young woman dying of cancer complications after refusing cancer care under the guidance of her influencer mother who charges £70/y for an annual membership to her site & £195 for a consultation & personalised 12-week programme. Thanks to @profstevegriffin.bsky.social for sharing
Our sister died because of our mum's cancer conspiracy theories, say brothers
Paloma Shemirani’s brothers say she refused chemotherapy because of their mother’s beliefs.
bbc.co.uk
it's the 10 year anniversary of a very important study
![In 2015, researchers Limb, Limb, Limb and Limb found that British doctors have surnames related to their specialties more often than expected by chance. Reproductive medicine had the largest proportion, with 1 in 52 doctors having specialty-relevant surnames including Horn, Hussey, and Woodcock. Second was Urology, with 1 in 59 related names such as Burns, Waterfall, Ball, and Koch.[96] "Dr Pain" appeared most commonly in general surgery.[96]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cyyd366g3hrxp5rynixm2mm3/bafkreiddq3sctguxn4xgf4mfxyu43qh7e2htev3iktz5siwagfpdswfy3q)
There is a false dichotomy drawn between "the ivory tower" and "the real world," and I'm here to report that in a post-industrial society, your real-world economy absolutely hinges on the university. University towns are factory towns. Universities drive economic activity, not the other way around.
Prof Christina Pagel@chrischirp.bsky.social · last yr.A must read
A lipid nanoparticle–delivered base-editing therapy was custom designed for an infant with a ureacycle disorder. The affected infant was treated at approximately 7 and 8 months of age. Read the Brief Report: nej.md/42XF03F #ASGCT2025 #MedSky @asgct.bsky.social
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...
nej.md
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
A depressing article about drug pricing for cancer patients, specifically for multiple myeloma. The good news in this case is that generic competition should be coming next year. The bad news is there will be another case jaut like this. www.propublica.org/article/revl...
The Price of Remission
When I was diagnosed with cancer, I set out to understand why a single pill of Revlimid cost the same as a new iPhone. I’ve covered high drug prices as a reporter for years. What I discovered shocked ...
propublica.org
1/ A long standing paradox in my mind (from always seeing immune "strength" or reactivity drawn as a spectrum from immunodeficiency to autoimmunity) was resolved this year at #AAI #Immunology2025. WHY do SO many people have both simultaneously? Each infection brings risk of developing autoimmunity!!
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
Is the UK paying the price for world’s most expensive visas? | The Observer
Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK
observer.co.uk
Great collection from one of the best paper hounds out there!
Waggoner Lab@labwaggoner.bsky.social · last yr.2024 @cincyresearch.bsky.social Annual Report: www.cincinnatichildrens.org/research/abo... scienceblog.cincinnatichildrens.org/from-the-dir... By the numbers: scienceblog.cincinnatichildrens.org/by-the-numbe... 50 remarkable discoveries: scienceblog.cincinnatichildrens.org/50-remarkabl...
This is a breakthrough in multi-modal single-cell technology
Wow, just implemented the new Cellpose-SAM from @computingnature.bsky.social in NimbusImage and it's *awesome*! Give it a try! nimbusimage.com
NEW Preprint Watch from Annette Wu & @wenjiang-nano.bsky.social @preprintclub.bsky.social reporting on @biorxiv-immuno.bsky.social preprint by @colinraposo.bsky.social et al. showing that checkpoint blockade drives expansion of exhausted T cell clones that develop functional memory rdcu.be/ek1kY
Progenitor exhausted T cells contribute to the formation of immunological memory
Nature Reviews Immunology - A preprint by Raposo et al. shows that immune checkpoint blockade drives the expansion of certain clones of exhausted T cells that can develop into functional memory...
rdcu.be
With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond. Here's an inside look into how this story was reported. It was a weird one. 🧵 www.nature.com/articles/d41...
British scientists are “over the moon” to be back in the EU’s Horizon funding programme after a 3-year Brexit lockout. New data reveals they have been awarded about £500m in grants since re-entry. International isolationism never works well. 🧪🔬⚛️🔭 www.theguardian.com/science/2025...
UK wins £500m in science grants from EU Horizon scheme after Brexit lockout
Exclusive: British scientists ‘over the moon’ with re-entry to funding scheme after losing out for three years
theguardian.com
Really happy to share this amazing story from my talented colleague Felipe Galvez-Cancino and many others. Really interesting work about the nature of anti-tumour immunity in the brain and how it can be modulated, in mice and humans! www.sciencedirect.com/science/arti...
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies
Glioblastoma is invariably lethal and responds poorly to immune checkpoint blockade. Here, we examined the impact of regulatory T (Treg) cell depletio…
sciencedirect.com
You call it an ifelse statement, I call it a lightweight, agentic decision module operating within a deterministic inference framework
'What’s the problem? Well, pretty much everything. These aren’t species returned from extinction.' @oxfordgeography.bsky.social's Dr Richard Grenyer argues that extinction is, for the time being, a symptom of our global economic system ⬇️
Why ‘de-extinct’ dire wolves are a Trojan horse to hide humanity’s destruction of nature
Extinction is, for the time being, forever – and a symptom of our global economic system.
theconversation.com
"...remember: your work is an act of resistance. Every experiment, every line of code, every collaboration defies those who would silence science." Dear US researchers: break the outrage addiction. I survived the besieging of science. So can you www.nature.com/articles/d41...
Dear US researchers: break the outrage addiction. I survived the besieging of science. So can you
As I watch US researchers respond to threats against science, I’m reminded of when scientists in Brazil navigated a similar storm.
nature.com
Sobering analysis by @nature.com on the Trump administration's NIH cuts. ~ 800 research projects have been terminated with research on HIV/AIDS, health disparities, transgender health, vaccines and COVID-19 being hit hardest, with some labs forced to close entirely. www.nature.com/articles/d41...
How Trump 2.0 is slashing NIH-backed research — in charts
Nature analyses which fields of science and US states are being hit hardest by grant terminations.
nature.com
Amazing 🚀 study w/ DNA seqFISH+, enabling mapping of 100,049 genomic loci, together with the nascent transcriptome for 17,856 genes, yielding unpredented insights into subnuclear structures in single cells www.nature.com/articles/s41...
Spatial multi-omics reveals cell-type-specific nuclear compartments - Nature
A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mous...
nature.com
George R. R. Martin on @biorxiv-evobio.bsky.social!
a man with a beard wearing a hat and glasses says ' hahahahahah ' on the screen
ALT: a man with a beard wearing a hat and glasses says ' hahahahahah ' on the screen
media.tenor.com
bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · last yr.On the ancestry and evolution of the extinct dire wolf https://www.biorxiv.org/content/10.1101/2025.04.09.647074v1
What if TCRs didn’t need to see peptides to bind MHC? A newly identified human TCR docks sideways onto HLA-DQ2.5—like an antibody. This could reshape how we think about antigen recognition 🧐🧐 @niclag.bsky.social @naturecomms.bsky.social
China is beating U.S. in biotech advances, report warns www.axios.com/2025/04/08/c...
China is beating U.S. in biotech advances, report warns
Beijing's ascendency in the sector could allow it to weaponize biotechnology against the U.S., the report warns.
axios.com
Contrary to popular belief, what is important in science is as much its spirit as its product: it is as much the openmindedness, the primacy of criticism, the submission to the unforeseen, however upsetting, as the result, however new that may be. – Francois Jacob www.nature.com/articles/s41...
