Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
Sven Klumpe
@svenklumpe.bsky.social
CryoFIB Development and In situ structural biology. NPC and TE enthusiast. Drosophilist but ready to switch to wherever biology takes us Getting to enjoy science with a group at IMBA/IMP of the Vienna BioCenter https://www.imp.ac.at/groups/sven-klumpe
Congratulations again, Polina! Such a great job, I am very much looking forward to the years ahead and to the discoveries we will make.
🎉Congratulations Polina Foteva, PhD student in the @sramundo.bsky.social & @svenklumpe.bsky.social groups, who received a competitive PhD fellowship from the Boehringer Ingelheim Fonds (BIF) More: www.oeaw.ac.at/gmi/detail/n... @gmivienna.bsky.social @imbavienna.bsky.social @impvienna.bsky.social
You're a devbio and stem cell enthusiast in Vienna? Come meet the community at #DevStem26 @istaresearch.bsky.social on June 16th! Only 3 days left to register & submit your abstract! Free registration 👇 devstem.pages.ist.ac.at
Development and Stem Cells Regional Meeting
devstem.pages.ist.ac.at
Join us on June 18 at ISTA for a day dedicated to developmental and stem cell biology, with talks, poster sessions, flash talks, and opportunities to connect across the Vienna life science community. More. 👇
How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇
That’s a wrap for #JCSimaging, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti. Thanks to everyone who joined us and made the conference such a wonderful community event. journals.biologists.com/jcs
Highly recommended!
Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo
Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo
Excited for the years to come working with this great crowd @juliusbrennecke.bsky.social @pauligroup.bsky.social @haselbachlab.bsky.social & Andela Saric! 🥳
A consortium of group leaders from IMP, IMBA (Vienna BioCenter) and ISTA has been awarded an FWF Emerging Fields grant to study how germ cells safeguard and pass on genetic information across generations.
#pictureofthemonth: March shows a “Cross-section” of the endoplasmic reticulum, a kind of membrane-labyrinth, using cryo-electron microscopy. More: www.biochem.mpg.de/plitzko March – Calendar of @mpiforbi.bsky.social and @mpibiochem.bsky.social 📸 Illustration by Jürgen Plitzko & Sven Klumpe
@embl.org at its best: collaborative, open, transformative, and just the right amount of crazy. Dreaming of mechanistic cell biology *in the natural environment*? Dream no more, rent the AML. www.biorxiv.org/content/10.6... www.youtube.com/watch?v=jepb... #WeFreezeOnTheBeach #ProtistsOnSky 🦠🌍🧪
We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏
Apply to the Master’s project position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/pos2607-masters-project #research #jobs #europe #biology
This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
nature.com
Hot take, pls hear me out: rather than single manuscripts, imagine single self correcting monographs per long term topic in a laboratory, version controlled like a GitHub repository, where additions are tracked with author lists to give credit. Peer review of the monograph addition. Could this work?
New Article! Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET
Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET
Nature Protocols, Published online: 30 January 2026; doi:10.1038/s41596-025-01284-zA protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.
dlvr.it
#Addendum to 1970 paper, “CYTOPLASMIC FILAMENTS OF AMOEBA PROTEUS: I. The Role of Filaments in Consistency Changes and Movement,” includes eight video sequences originally recorded on 16-mm films. No technology was available at the time to include this data. 🎞️ rupress.org/jcb/article/... #Actin
#Zebrafish 🐟 meeting klaxon🧨 The registration period for the 1st German Zebrafish Meeting (16-18 Sept) is open www.germanfishmeeting.org with Sessions on Development, Pharma, Behavior, Omics, and more. Deadline for Abstracts at the end of April. Hope to see y'all there! 🧪 (1/n)
1st German Fish Model Research Meeting | German Fish Model Research Meeting
Discover the 1st German Fish Model Research Meeting—uniting global experts on zebrafish, cavefish, killifish, medaka & more. Join us to collaborate, share breakthroughs, and advance fish biology resea...
germanfishmeeting.org
I am so deeply sorry to hear of the passing of Peer Bork, whom I met when I started my editorial career at @emboreports.org I saw him last September & cannot believe he is gone My ❤️ goes out to his family & friends, & his extended scientific family. Terrible news. www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
embl.org
We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...
Redirecting
doi.org
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
lab.plus
🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Excited to share our new @narjournal.bsky.social paper! Using ReLo and AlphaFold, we described a network of interactions between Drosophila piRNA pathway factors suggesting new links how they coordinate to ensure transposon silencing and genome integrity. academic.oup.com/nar/article/...
Really awesome findings, congrats!
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...
Congrats, Ulrich! Looking forward to see the amazing science your lab will do. Highly recommended for anyone searching for a PhD position!
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
So good I’m almost worried it is fake but anyhow an amazing message to start the week to 😊
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT! She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!
🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT! She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...
Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup). A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.
These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x
High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1