Sven Klumpe

@svenklumpe.bsky.social

CryoFIB Development and In situ structural biology. NPC and TE enthusiast. Drosophilist but ready to switch to wherever biology takes us Getting to enjoy science with a group at IMBA/IMP of the Vienna BioCenter https://www.imp.ac.at/groups/sven-klumpe

Congratulations again, Polina! Such a great job, I am very much looking forward to the years ahead and to the discoveries we will make.

Gregor Mendel Institute of Molecular Plant Biology@gmivienna.bsky.social · 2mo ago

🎉Congratulations Polina Foteva, PhD student in the @sramundo.bsky.social & @svenklumpe.bsky.social groups, who received a competitive PhD fellowship from the Boehringer Ingelheim Fonds (BIF) More: www.oeaw.ac.at/gmi/detail/n... @gmivienna.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏

Institute of Molecular Biotechnology@imbavienna.bsky.social · 8mo ago

Apply to the Master’s project position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/pos2607-masters-project #research #jobs #europe #biology

Hot take, pls hear me out: rather than single manuscripts, imagine single self correcting monographs per long term topic in a laboratory, version controlled like a GitHub repository, where additions are tracked with author lists to give credit. Peer review of the monograph addition. Could this work?

I am so deeply sorry to hear of the passing of Peer Bork, whom I met when I started my editorial career at @emboreports.org I saw him last September & cannot believe he is gone My ❤️ goes out to his family & friends, & his extended scientific family. Terrible news. www.embl.org/news/embl-an...

In remembrance of Peer Bork  | EMBL

EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.

embl.org

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊

lab.plus

IMP@impvienna.bsky.social · 11mo ago

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

Congrats, Ulrich! Looking forward to see the amazing science your lab will do. Highly recommended for anyone searching for a PhD position!

Ulrich Hohmann@hohmannulrich.bsky.social · last yr.

Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!

Congratulations to @vdeneke.bsky.social & Andreas Blaha @impvienna.bsky.social for their research on vertebrate fertilization, which was awarded this year's ÖGMBT Life Science Research Award in Austria for basic research!

IMP@impvienna.bsky.social · last yr.

🎉Congrats to our @vdeneke.bsky.social, postdoc in the @pauligroup.bsky.social, who has received the 2025 Life Sciences Research Award Austria from the ÖGMBT! She's recognised for her groundbreaking work on the molecular mechanisms of fertilisation: www.imp.ac.at/news/article...

Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup). A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.

Sjors Scheres@sjorsscheres.bsky.social · last yr.

These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1