and forgot one of the best parts. Using ShinyCell Emma made the single cell RNA seq data browsable and very interactive. A great resource...check it out! axolotl-limb-regen-scrnaseq.serve.scilifelab.se/app/axolotl-...

Nick Leigh@niche-leigh.bsky.social · 3mo ago

🐸Do salamanders need adaptive immunity to regenerate limbs and tails? 🐸 Nope! 🚨Check out back-to-back pre-prints from PhD student in our lab Chimezie (tinyurl.com/42wst3bh) and from our collaborators the Max Yun lab (tinyurl.com/b92rzwzr)

Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...

🐸Do salamanders need adaptive immunity to regenerate limbs and tails? 🐸 Nope! 🚨Check out back-to-back pre-prints from PhD student in our lab Chimezie (tinyurl.com/42wst3bh) and from our collaborators the Max Yun lab (tinyurl.com/b92rzwzr)

Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery https://www.biorxiv.org/content/10.64898/2026.03.27.714371v1

Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery doi.org/10.64898/202... DupyliCate - mining, classifying, and characterizing gene duplications doi.org/10.1101/2025... #Genomics #Bioinformatics #Evolution

Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery https://www.biorxiv.org/content/10.64898/2026.03.27.714371v1

Novabrowse: A Tool for High-Resolution Synteny Analysis, Ortholog Detection, and Gene Signal Discovery https://www.biorxiv.org/content/10.64898/2026.03.27.714371v1

Sounds interesting!!!

Nick Leigh@niche-leigh.bsky.social · 4mo ago

New tool from the lab...check out Novabrowse: An interactive and customizable tool for interpreting BLAST results in genomic context! www.biorxiv.org/content/10.6... Does your favorite gene seems to be missing from your species of interest? Are you sure? 🧵👇 1/n

This looks very cool 😎 🔗 to download: github.com/RegenImm-Lab...

GitHub - RegenImm-Lab/Novabrowse: Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative gen...

Novabrowse a BLAST results interpretation tool and sequence alignment viewer for gene synteny analysis, gene position on chromosome visualization, and comparative genomics tool for multi-species or...

github.com

Nick Leigh@niche-leigh.bsky.social · 4mo ago

New tool from the lab...check out Novabrowse: An interactive and customizable tool for interpreting BLAST results in genomic context! www.biorxiv.org/content/10.6... Does your favorite gene seems to be missing from your species of interest? Are you sure? 🧵👇 1/n

New tool from the lab...check out Novabrowse: An interactive and customizable tool for interpreting BLAST results in genomic context! www.biorxiv.org/content/10.6... Does your favorite gene seems to be missing from your species of interest? Are you sure? 🧵👇 1/n

Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6... @idrm.ox.ac.uk @oxforddpag.bsky.social

🗓️ 23-26 June 2026 🇸🇪 #PALS #summerschool in #OMICS is back! Soon registration and info about speakers for the 3rd edition! Organized by @claudiocantu81.bsky.social and me, @remeseiro-lab.bsky.social, with the support from @scilifelab.se and @kawresearch.bsky.social

Claudio Cantù@claudiocantu81.bsky.social · 8mo ago

Save the date 23-26 June 2026 The Third Edition of The PALS Summer School in OMICS is on! Soon registration+other info If you are interested to teach (if you are a former participant) please get in touch with me or @remeseiro-lab.bsky.social 🙏 @scilifelab.se @kawresearch.bsky.social

Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄 Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl

The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

science.org

Yesterday @jacoates.bsky.social and I gave talks on pre-prints hosted by the @lunduniversity-med.bsky.social . Jonny gave a great primer on the history of pre-prints and debunked myths about them. I spoke on our experiences with preprints and was encouraged to see this feedback after the talks👇

💥OUR LAB IS HIRING!!💥 We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity. Application link: tinyurl.com/3tpvphpm #SciJob #JobAlert

I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...

Decoding sex differences in human immunity through systems immunology

Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

doi.org

‼️Our first review is out‼️ Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments. Excellent work by @resabut.bsky.social & Tianze Cao!

Decoding sex differences in human immunity through systems immunology

Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

academic.oup.com

🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)

CellTalk HHD | Human Heart Development Research

CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.

heartdevelopment.org

Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...

Immune-mediated cardiac development and regeneration

The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…

sciencedirect.com

Come and work with us OOH @oxforddpag.bsky.social: ❤️ organoids to study 1) failing hearts and 2) metabolite signalling, with @novonordisk.bsky.social and wonderful colleagues 1) Andrew Lewis & Chris Toepfer @rdmoxford.bsky.social; 2) Yimon Aye @oxfordchemistry.bsky.social. Reach out if interested!

Radcliffe Department of Medicine@rdm.ox.ac.uk · last yr.

The Novo Nordisk – Oxford Fellowship Programme open for applications The programme is focused on research in diabetes, obesity, cardiovascular diseases, and other cardiometabolic conditions. There are 4 fully funded fellowships (3 years). For more info on how to apply, visit shorturl.at/3l47e

🔬👩‍🔬What sparked your interest in science?👨‍🔬🧫 For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration! 📖 Read more: www.stemcellcenter.lu.se/article/unis...

UniStem Day 2025: A Decade of Inspiring Future Scientists in Lund

Lund University.

stemcellcenter.lu.se

Great write-up from Alexis! UniStem is an amazing initiative and given the current attacks on science it’s critical we work to educate and motivate the future generation to be pro-science.

Lund Stem Cell Center@lundstem.bsky.social · last yr.

🔬👩‍🔬What sparked your interest in science?👨‍🔬🧫 For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration! 📖 Read more: www.stemcellcenter.lu.se/article/unis...

The newt Pleurodeles waltl has amazing biological features, like the ability to regenerate tail and limbs! Are the secrets to this regenerative capacity in their genome? In this collaborative work from the Leigh, Yun, and Simon labs we explored this question. www.cell.com/cell-genomic... (1/x)

A #Pleurodeles on the cover. Interested in this #giantgenome, #salamander #regeneration, #noncodingRNA landscape? Pls check out: www.cell.com/cell-genomic.... Many great labs involved, special thanks to co-senior authors @maxyunlab.bsky.social, and @niche-leigh.bsky.social

Newt Genome assembly is out. Congratulations @andrassimon.bsky.social @maxyunlab.bsky.social @niche-leigh.bsky.social labs.🍻 www.cell.com/cell-genomic...

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...

cell.com

And the newt genome ms is finally out! www.cell.com/cell-genomic... Thanks @andrassimon.bsky.social @niche-leigh.bsky.social labs for an amazing collab, and specially Tom Brown for great assembly skills. @dcgenomecenter.bsky.social @crtd-tud.bsky.social @mpicbg.bsky.social @poldresden.bsky.social

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Understanding molecular mechanisms behind newts’ exceptional regenerative capability has been limited because of their large, repeat-element-rich genome. Brown et al. present the most complete chromos...

cell.com

🚀 Lund University's Faculty of Medicine seeks candidates for 2 Assoc. Senior Lecturer roles in: ➡️ Translational research in advanced therapies: https://buff.ly/4aAb3ci ➡️ Basic research in regenerative medicine & disease mechanisms: https://buff.ly/3E8BKsl Apply by 10 Feb to join us in Lund!

Interested in working with 🐸, 🐭, stem cells, or computational methods 🖥️ to delve into the unknowns of regeneration in our new lab? Looking forward to enthusiastic and ambitious applicants! PhD program applications open! 🔗 www.phd.tuebingen.mpg.de/14722/phdpro... Please RT! 🙌

Max Planck Campus Tübingen@maxplanckcampus.bsky.social · 2y ago

@mpi-bio-fml.bsky.social are now accepting applications or fully-funded biology #PhD positions at the Max Planck Institute for Biology and Friedrich Miescher Laboratory. The new cohort starts September 2025. Find out more about the projects you could be working on: www.phd.tuebingen.mpg.de #IMPRS