Amazing work by GOA convener Dr Zoe Grant! Her study on the impact of the 3D genome in heart disease was just published in Science! Read about it here: www.science.org/doi/abs/10.1...

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type–specific gene regulation is linked to the reorganization of three-dimensio...

science.org

Gladstone Institutes@gladstoneinst.bsky.social · last wk.

Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.

Congenital heart disease is the most common birth defect. In a new study published in @science.org researchers investigated why losing just one functional copy of the gene TBX5—a genetic cause of congenital heart disease—can have such devastating effects on heart development.

Discovery Spotlight│Misfolded DNA Blueprint: A New Origin for Genetic Disease

YouTube video by Gladstone Institutes

youtube.com

Want to learn about rewiring of the 3D genome in cancer? Join us next week for GOA!

GOA - Genome Organisation Australia@genome-org-aus.bsky.social · 3w ago

Our July GOA speaker is @aachinger.bsky.social. Join us to hear her talk titled: 3D chromatin rewiring governs lineage identity in prostate cancer. Registration: unimelb.zoom.us/webinar/regi...

Our July GOA speaker is @aachinger.bsky.social. Join us to hear her talk titled: 3D chromatin rewiring governs lineage identity in prostate cancer. Registration: unimelb.zoom.us/webinar/regi...

@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Nature Protocols@natprot.nature.com · 3w ago

New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)

Our July GOA speaker is @aachinger.bsky.social. Join us to hear her talk titled: 3D chromatin rewiring governs lineage identity in prostate cancer. Registration: unimelb.zoom.us/webinar/regi...

Haplotype-resolved genome architecture mapping uncovers pervasive structural heterogeneity between human homologous chromosomes https://www.biorxiv.org/content/10.64898/2026.06.16.732681v1

JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)

Single-molecule nucleosome spacing coordinates chromatin fiber interactions

Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...

biorxiv.org

Interested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation? @karissalhansen.bsky.social will be presenting her work **Tues June 23rd 8am CET** www.biorxiv.org/content/10.6... www.science.org/doi/10.1126/... Thank you @genome-org-aus.bsky.social ! 👇

GOA - Genome Organisation Australia@genome-org-aus.bsky.social · 2mo ago

Only one week to go until our next GOA seminar! @karissalhansen.bsky.social will present here work on the mechanisms of long-range enhancer-promoter communication. Registration link: unimelb.zoom.us/webinar/regi...

Only one week to go until our next GOA seminar! @karissalhansen.bsky.social will present here work on the mechanisms of long-range enhancer-promoter communication. Registration link: unimelb.zoom.us/webinar/regi...

Going from the discovery of epigenetic silencing of CTCF insulators www.nature.com/articles/s41... to aberrant E-P looping www.cell.com/molecular-ce... to a successful clinical trial www.nature.com/articles/s41... all from Brad Bernstein's lab

Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs - Nature

Gastrointestinal stromal tumours can be initiated by gain-of-function mutations of the KIT or PDGFRA oncogenes but also by loss of the metabolic complex succinate dehydrogenase (SDH), which leads to D...

nature.com

Please join us for the next edition of the GOA monthly seminar series Dr Karissa Hansen Registration link: unimelb.zoom.us/webinar/regi...

AEpiA 2026 early bird registration open now! Calling all epigenetics researchers, let’s meet, share, and connect! 14–16 Sep | Adelaide 🇦🇺 | National Wine Centre Register: 2026aepia.com.au/registration Abstracts: 2026aepia.com.au/abstracts #AEpiA2026 #Epigenetics #Chromatin

Lorne Genome 2027 will be held 14 to 17th February in Lorne Australia. Our invited speakers will include Karen Arndt, Neil Brockdorff, Laura Banaszynski and Fides Zenk.

Please join us for the next edition of the GOA monthly seminar series Dr Matthew Romero Registration link: unimelb.zoom.us/webinar/regi...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Excited to share the final version of our paper with @ajithvasanthan.bsky.social @petermaccc.bsky.social on the gene we discovered, Dreg1 @elife.bsky.social Here we probe a novel knockout to identity a specific role for Dreg1 in group 2 ILC development elifesciences.org/articles/109...

Almost time for the next edition of the GOA seminar! Join us to hear from A/Prof. R. Babak Faryabi!

GOA - Genome Organisation Australia@genome-org-aus.bsky.social · 4mo ago

Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social! Registration link: unimelb.zoom.us/webinar/regi...

One more week until our first GOA for the year!

GOA - Genome Organisation Australia@genome-org-aus.bsky.social · 4mo ago

Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social! Registration link: unimelb.zoom.us/webinar/regi...

Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology

Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

nature.com

Please join us for the next edition of the GOA monthly seminar series A/Prof. R. Babak Faryabi @faryabi.bsky.social! Registration link: unimelb.zoom.us/webinar/regi...

🚨 Postdoc in 3D genome architecture – join the @jumanaaha.bsky.social lab at the MPI-IE, Freiburg (🇩🇪) The wonderful lab of Jumana AlHaj Abed is pushing the limits of how chromosomes fold and interaction – and we need someone who can code, image, & think across scales. Apply here: s.gwdg.de/9c8838

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination. bit.ly/4aPkNBc

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology

Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

bit.ly

#WIMMReads 🧪 From Jim Hughes, Douglas Higgs and Mira Kassouf: actively transcribed genes can define chromatin boundaries, linking gene activity directly to 3D genome organisation. Read more 👇 #GenomeBiology #Chromatin #WIMM @rdm.ox.ac.uk @medsci.ox.ac.uk #AkademicSky

A functional overlap between actively transcribed genes and chromatin insulator elements - The EMBO Journal

The mammalian genome is organised into large topologically associating domains (TADs) and smaller sub-TADs or enhancer-promoter loops, which may contribute to the regulation of gene expression. These ...

doi.org